资源 » 参考数据库 » 客户发表文献

至今，GenScript的服务及产品已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次，处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果，再次证明GenScript 有能力帮助业内科学家Make research easy.

Sub-ångström cryo-EM structure of a prion protofibril reveals a polar clasp.

Nat. Struct. Mol. Biol.. 2018-02; 
Gallagher-JonesMarcus，GlynnCalina，BoyerDavid R，MartynowyczMichael W，HernandezEvelyn，MiaoJennifer，ZeeChih-Te，NovikovaIrina V，GoldschmidtLukasz，McFarlaneHeather T，HelgueraGustavo F，EvansJames E，SawayaMichael R，CascioDuilio，EisenbergDavid S，GonenTamir，RodriguezJo
Products/Services Used Details Operation
Peptide Synthesis … were selected and aligned. Characterization of proto-PrP Sc peptide. The synthetic peptide, QYNNQNNFV, corresponding to residues 168–176 of the bank vole prion protein was purchased from GenScript. The peptide used … Get A Quote

摘要

The atomic structure of the infectious， protease-resistant， β-sheet-rich and fibrillar mammalian prion remains unknown. Through the cryo-EM method MicroED， we reveal the sub-ångström-resolution structure of a protofibril formed by a wild-type segment from the β2-α2 loop of the bank vole prion protein. The structure of this protofibril reveals a stabilizing network of hydrogen bonds that link polar zippers within a sheet， producing motifs we have named 'polar clasps'.

关键词

Article Link >