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Role of the Ca-Calcineurin-Nuclear Factor of Activated T cell Pathway in Mitofusin-2-Mediated Immune Function of Jurkat Cells.

Chin. Med. J.. 2018-02;

XuXiu-Ping，YaoYong-Ming，ZhaoGuang-Ju，WuZong-Sheng，LiJun-Cong，JiangYun-Long，LuZhong-Qiu，HongGuang-L

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Custom RNAi Services	… Small interfering RNAs (siRNAs) containing the target sequence 5'-GTCAAAGGTTAC CTATCCAAA-3' were designed to bind to MFN2 mRNA. Full-length human MFN2 cDNA was obtained from GenScript Corporation (Piscataway, NJ, USA) …	Get A Quote

摘要

Mitofusin-2 (MFN2)， a well-known mitochondrial fusion protein， has been shown to participate in innate immunity， but its role in mediating adaptive immunity remains poorly characterized. In this study， we explored the potential role of MFN2 in mediating the immune function of T lymphocytes.