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Characterization of Transgenic Silkworm Yielded Biomaterials with Calcium-Binding Activity.

PLoS One.. 2016-06;

Wang S, Zhang Y, Yang M, Ye L, Gong L, Qian Q, Shuai Y, You Z, Chen Y, Zhong B.

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Gene Synthesis	... Dimerized DNA fragments containing the CABP sequence with certain improvements according to a report described previously[15] were used in this study. The sequence was artificially synthesized by GenScript (Piscataway, NJ, USA) (Fig 1a). ...	Get A Quote

摘要

Silk fibers have many inherent properties that are suitable for their use in biomaterials. In this study, the silk fibroin was genetically modified by including a Ca-binding sequence, [(AGSGAG)6ASEYDYDDDSDDDDEWD]2 from shell nacreous matrix protein. It can be produced as fibers by transgenic silkworm. The Ca-binding activity and mineralization of the transgenic silk fibroin were examined in vitro. The results showed that this transgenic silk fibroin had relatively higher Ca-binding activity than unmodified silk fibroin. The increased Ca-binding activity could promote the usage of silk fibroin as a biomaterial in the pharmaceutical industry. This study shows the possibility of using silk fibroin as a mineralizat... More