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A bifunctional actuator to correct loss-of-function deficits in cardiac voltage-gated sodium channels

Authors: Lucile Fossier, Marc Yehya, Richard Z Zhuang, Sri Karthika Shanmugam, Ryan Mahling, Timothy Cho, Audrey Kochiss, Allen L Hsu, Sandra B Gabelli, Gordana Vunjak-Novakovic, Henry M Colecraft, Manu Ben-Johny

Journal: Science advences

PubMed ID: 42853924

Doi: 10.1126/sciadv.aeb2110

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MFN2-associated astrocyte dysfunction contributes to neuronal hyperexcitability and depressive-like behaviors

Authors: Feng-Xia Ma, Min Wang, Shuo-Yan Fang, Xiao-Xin Wang, Shen-Han Xu, Xin-Xin Zhao, Yu-Xiao Liu, Cong Wang, Chen Qiao, Qiu-Ling Wang, Lei Cao

Journal: Science advences

PubMed ID: 42886804

Doi: 10.1126/sciadv.aed8795

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Gliadin-specific CD4+ T cells exhibit functional diversity independent of TCR usage or epitope specificity

Authors: Claerwen M Jones, Jia Jia Lim, Stefan A Schattgen, Tiing Jen Loh, Hien Thy Dao, Mai T Tran, Angela Nguyen, Pirooz Zareie, Nathan J Felix, Paul G Thomas, Melinda Y Hardy, Jason A Tye-Din, Hugh H Reid, Jamie Rossjohn, Nicole L La Gruta

Journal: Science advences

PubMed ID: 42826196

Doi: 10.1126/sciadv.aei3175.

Products & Services: PCR Cloning and Subcloning

SMARCA5 facilitates cohesin localization at R-loops to prevent transcription-replication collisions

Authors: Boya Gao, Elizabeth M Irvin, Fengqi Zhang, Parminder Kaur, Ruoxi W Wang, Xiaofeng A Su, Zhubing Shi, Hong Wang, Li Lan

Journal: Cell death and differentiation

PubMed ID: 42946759

Doi: 10.1038/s41418-026-01888-2

Products & Services: PCR Cloning and Subcloning

A multitargeting nanoparticle-based vaccine for enhanced anticancer immunotherapy in HER2-Positive breast cancer

Authors: Sen Liu, Yiqiang Zhu, Tao Chen, Xiaoqing Liu, Jintao Lai, Meilin Hu, Yaoming Liu, Haiyue Rao, Bin Zhang, Shiqi Xiao, Haojie Peng, Taizhen Liang, Lixiang Xie, Guochang Qiu, Shan Li, Xiancai Ma

Journal: Materials Today Bio

Doi: 10.1016/j.mtbio.2026.103524

Products & Services: Protein Electrophoresis and Western

Lipid-organized tetramerization of PLPP1 defines the molecular basis of spatial lipid phosphate signaling

Authors: Yunhai Li, Qingning Yuan, Zhenyu Cao, Liuqing Zhu, Jiuyin Xu, Cheng-Cen Guo, James Jiqi Wang, Youwei Xu, Shuai Li, Tianyu Li, Yang Li, Yong Li, H. Eric Xu, Canrong Wu

Journal: Nature Communications

Doi: 10.1038/s41467-026-78196-3

Products & Services: Peptide Synthesis

Ultrasound-Driven Lysis of Tumor-Resident Bacteria Awakens Innate Immunity for Systemic Cancer Therapy

Authors: Wenya Zhou, Haoqi Zhu, Yu Liu, Haoze Li, Min Wu, Siqi Li, Rui Qu, Shaopeng Liu, Hanqing Qian, Bin Xue, Yi Cao, Xiqun Jiang, Xu Zhen

Journal: Journal of the American Chemical Society

Doi: 10.1021/jacs.6c14587

Products & Services: Peptide Synthesis

Recordanelles for transcriptome-wide single-cell RNA recording in human cells

Authors: Christopher D Reinkemeier, Marcos Manero-Carranza, Rick Farouni, Federica Filice, Alexander Klotz, Konstantin Schneider-Heieck, Tim L Andermann, Randall J Platt

Journal: Nature Biotechnology

PubMed ID: 42907534

Doi: 10.1038/s41587-026-03327-6

Products & Services: Gene Synthesis

Near-infrared photochromic miniprotein enables photoacoustic molecular imaging of acute inflammation and intracellular antigens

Authors: Olena S Oliinyk, Yirui Xu, Jinhuan Luo, Kateryna O Tokarchuk, Kyrylo Yu Manoilov, Josie van de Klashorst, Matthew P Eyring, Mu-En Wang, Ming Chen, Pengfei Song, John W Hickey, Junjie Yao, Vladislav V Verkhusha

Journal: Nature Methods

PubMed ID: 42870097

Doi: 10.1038/s41592-026-03255-y.

Products & Services: Gene Synthesis

Innate sensor responses set a supra-unitary threshold for viral replication

Authors: Kojiro Mukai, Dongya Jia, Mamata Panigrahi, Thomas Tayman, Graham Brogden, Ying-Han Chen, Nazmul Haque, Gunjan Arora, Joshua E Mutterperl, Ian Poe, Chenyu Zhang, Zahin Islam, Ronald Holewinski, Thorkel Andresson, Di Wu, Grzegorz Piszczek, Joseph Marcotrigiano, J Robert Hogg, Suk See De Ravin, Nasir S Malik, Avindra Nath, Ekaterina Viktorova, Anna Zimina, George A Belov, Banu Bayyurt-Kocabaş, Grégoire Altan-Bonnet, Nihal Altan-Bonnet

Journal: Cell

PubMed ID: 42956738

Doi: 10.1016/j.cell.2026.10.004

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