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IgG-Bridging–Seeded Synergistic Aggregation of SARS-CoV-2 Spikes Underlies Potent Neutralization by a Low-Affinity Antibody

Authors: Niannian Lv, Peng Chen, Xiaobin Dai, Hu Xu, Ziheng Li, Zelin Shan, Jinqian Li, Fenglin Guo, Yuanfang Chen, Jiayi Li, Yiqian Huang, Guizhi Dong, Yifan Jiang, Liang Chen, Xuanyu Nan, Hanjun Zhao, Kang Zhang, Shilong Fan, Yuanchen Dong, Dongsheng Liu, Xinquan Wang, Deli Huang, Xiaojing Pan, Chunying Chen, Zhihua Liu, Li-Tang Yan, Qi Zhang, Linqi Zhang, Yuliang Zhao, Yuhe Renee Yang

Journal: Advanced science (Weinheim, Baden-Wurttemberg, Germany)

PubMed ID: 41355083

Doi: 10.1002/advs.202517192. Online ahead of print.

Products & Services: Proteins, Expression, Isolation and Analysis

Thermodynamic Profiling Reveals DNA Polymerase Template Binding, Substrate Incorporation, and Exonuclease Function

Authors: Yaping Sun, Wu Lin, Kang Fu, Jie Gao, Xianhui Zhao, Yun He, Hui Tian

Journal: International Journal of Molecular Sciences

Doi: doi.org/10.3390/ijms262411909

Products & Services: Gene Synthesis Plasmid DNA Preparation Proteins, Expression, Isolation and Analysis Single-Stranded DNA Synthesis

Cynarin as a potent anti‑osteolytic agent: Targeting MAPK and Nrf2‑Keap1 pathways for osteoclast inhibition and bone protection

Authors: Rui Chao, Yexin Wang, Zhan Liu, Tianhao Wan, Yi Mao, Xinru Xie, Lei Sun, Weifeng Xu, Xuzhuo Chen, Shanyong Zhang

Journal: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

PubMed ID: PMC12488209

Doi: 10.3892/ijmm.2025.5647

Products & Services: Proteins, Expression, Isolation and Analysis

Excessive vigorous exercise impairs cognitive function through a muscle-derived mitochondrial pretender

Authors: Yan Huang, Biao Hu, Ya Liu, Ling-Qi Xie, Yu Dai, Yu-Ze An, Xin-Yi Peng, Ya-Lun Cheng, Yi-Fan Guo, Wei-Hong Kuang, Yao Xiao, Xin Chen, Yong-Jun Zheng, Gen-Qing Xie, Jian-Ping Wang, Hui Peng, Xiang-Hang Luo

Journal: Cell metabolism

PubMed ID: 41344322

Doi: doi.org/10.1016/j.cmet.2025.11.002

Products & Services: Nucleic Acid Purification & Analysis

Engineered ipilimumab variants that bind human and mouse CTLA-4

Authors: Brett Robison 1, S J Diong 1, Anusha Kumar 1, Thomas M Moon , Olin Chang , Bryant Chau , Christine Bee , Ishita Barman , Arvind Rajpal , Alan J Korman , Sean West , Pavel Strop , Peter S Lee

Journal: MAbs

PubMed ID: 39849917

Doi: 10.1080/19420862.2025.2451296

Products & Services: Combinatorial DNA Libraries

The prion-like characteristic of ORF3 contributes to virion release and pathogenesis of hepatitis E virus

Authors: Yajing Wang, Houlu Tian, Na Shi, Chunyan Wu, Yaowei Huang, Yongling Yang, Qiang Ding, Xu Zheng, Qin Zhao, Zhaonong Hu, Jiaojiao Luo, Lele Feng, Lingdong Xu, Mick F Tuite, Hongying Chen, Yuchen Nan

Journal: Proceedings of the National Academy of Sciences of the United States of America

PubMed ID: 41343667

Doi: 10.1073/pnas.2511801122

Products & Services: Polyclonal Antibody Services

SnRK2.5-mediated phosphorylation of PIN2 links osmotic stress signaling with auxin dependent root adaptive growth in Arabidopsis

Authors: Shujuan Zhang, Zilong Cui, Yu Gao, Qi Liao, Wenyan Li, Siqi Yuan, Zhuomeng Li, Xinwen Zhang, Kai Ding, Wenjing Zhang, Like Shen, Jörg Kudla, Wenhua Zhang, Jing Zhang, Qun Zhang

Journal: Molecular Plant

PubMed ID: 41353562

Doi: 10.1016/j.molp.2025.12.002

Products & Services: Proteins, Expression, Isolation and Analysis Catalog Antibody

Discovery of novel pyrrolidine-2,5-dione scaffold PICK1 PDZ inhibitors as anti-ischemic stroke agents

Authors: Yichen Jiang, Qi Liu, Ting Zhu, Ruiguo Liang, Yujiao Qin, Xiya Guo, Jiacheng Wang, Ping Li, Jie Zhou, Han Ju, Mingxin Dong

Journal: European Journal of Medicinal Chemistry

PubMed ID: 41386205

Doi: 10.1016/j.ejmech.2025.118410

Products & Services: Plasmid DNA Preparation

Human Substance P Interactions with G Protein-Coupled Receptor NK1R Observed by NMR in Solution

Authors: Haoyi Ge, Lingyun Yang, Changran Chen, Yuxin Xu, Dongsheng Liu, Kurt Wüthrich