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Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands

Authors: Edmond M Linossi , Kunlun Li , Gianluca Veggiani , Cyrus Tan , Farhad Dehkhoda , Colin Hockings , Dale J Calleja , Narelle Keating , Rebecca Feltham , Andrew J Brooks , Shawn S Li , Sachdev S Sidhu , Jeffrey J Babon , Nadia J Kershaw , Sandra E Nicholson

Journal: Nat Commun

PubMed ID: 34857742

Doi: s41467-021-26983-5

Products & Services: Peptide Synthesis

Blood virosphere in febrile Tanzanian children

Authors: Samuel Cordey, Florian Laubscher, Mary-Anne Hartley, Thomas Junier, Kristina Keitel, Mylène Docquier, Nicolas Guex, Christian Iseli, Gael Vieille, Philippe Le Mercier, Anne Gleizes, Josephine Samaka, Tarsis Mlaganile, Frank Kagoro, John Masimba, Zamzam Said, Hosiana Temba, Gasser H Elbanna, Caroline Tapparel, Marie-Celine Zanella, Ioannis Xenarios, Jacques Fellay, Valérie D'Acremont, Laurent Kaiser

Journal: Emerg Microbes Infect

PubMed ID: 33929935

Doi: 10.1080/22221751.2021.1925161

Products & Services: Gene Synthesis

Long-term trajectories of SARS-CoV-2 neutralizing antibodies and predictive value of first dose vaccination-induced IgG-antibodies in hemodialysis patients

Authors: F P Tillmann, H Still, Philipp von Landenberg

Journal: Int Urol Nephrol

PubMed ID: 34860338

Doi: 10.1007/s11255-021-03076-2

Products & Services: Protein and Antibody Reagents

Impaired Immune Response to COVID-19 Vaccination in Patients with B-Cell Malignancies after CD19 CART Cell Therapy

Authors: Saurabh Dahiya, Tim Luetkens, Forat Lutfi, Stephanie V Avila, Thierry Iraguha, Philip J Margiotta, Kim G Hankey, Patricia Lesho, Jennie Y Law, Seung Tae Lee, John W Baddley, Mehmet Hakan Kocoglu, Jean Yared, Nancy M Hardy, Aaron P Rapoport, Djordje Atanackovic

Journal: Blood Adv

PubMed ID: 34941995

Doi: 10.1182/bloodadvances.2021006112

Products & Services: Gene Synthesis

A highly sensitive cell-based luciferase assay for high-throughput automated screening of SARS-CoV-2 nsp5/3CLpro inhibitors

Authors: K Y Chen, T Krischuns, L Ortega Varga, E Harigua-Souiai, S Paisant, A Zettor, J Chiaravalli, D Courtney, A O'Brien, S C Baker, C Isel, F Agou, Y Jacob, A Blondel, N Naffakh

Journal: biorxiv

PubMed ID: 34981051

Doi: 10.1101/2021.12.18.473303

Products & Services: PCR Cloning and Subcloning

Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization

Authors: Sandile Cele, Laurelle Jackson, David S Khoury, Khadija Khan, Thandeka Moyo-Gwete, Houriiyah Tegally, James Emmanuel San, Deborah Cromer, Cathrine Scheepers, Daniel G Amoako, Farina Karim, Mallory Bernstein, Gila Lustig, Derseree Archary, Muneerah Smith, Yashica Ganga, Zesuliwe Jule, Kajal Reedoy, Shi-Hsia Hwa, Jennifer Giandhari, Jonathan M Blackburn, Bernadett I Gosnell, Salim S Abdool Karim, Willem Hanekom, Anne von Gottberg, Jinal N Bhiman, Richard J Lessells, Mahomed-Yunus S Moosa, Miles P Davenport, Tulio de Oliveira, Penny L Moore, Alex Sigal

Journal: Nature

PubMed ID: 35016196

Doi: 10.1038/s41586-021-04387-1

Products & Services: Monoclonal Antibody Services

Metabolic engineering of Bacillus subtilis with an endopolygalacturonase gene isolated from Pectobacterium carotovorum; a plant pathogenic bacterial strain

Authors: Nagina Rafique, Saiqa Bashir, Muhammad Zubair Khan, Imran Hayat, Willium Orts, Dominic W S Wong

Journal: PLoS ONE

PubMed ID: 34936645

Doi: 10.1371/journal.pone.0256562

Products & Services: Gene Synthesis

SARS-CoV-2 Omicron has extensive but incomplete escape of Pfizer BNT162b2 elicited neutralization and requires ACE2 for infection

Authors: Sandile Cele, Laurelle Jackson, David S Khoury, Khadija Khan, Thandeka Moyo-Gwete, Houriiyah Tegally, James Emmanuel San, Deborah Cromer, Cathrine Scheepers, Daniel Amoako, Farina Karim, Mallory Bernstein, Gila Lustig, Derseree Archary, Muneerah Smith, Yashica Ganga, Zesuliwe Jule, Kajal Reedoy, Shi-Hsia Hwa, Jennifer Giandhari, Jonathan M Blackburn, Bernadett I Gosnell, Salim S Abdool Karim, Willem Hanekom, Anne von Gottberg, Jinal Bhiman, Richard J Lessells, Mahomed-Yunus S Moosa, Miles P Davenport, Tulio de Oliveira, Penny L Moore, Alex Sigal

Journal: medrxiv

PubMed ID: 34909788

Doi: 10.1101/2021.12.08.21267417

Products & Services: Monoclonal Antibody Services

Local Charge Distributions, Electric Dipole Moments, and Local Electric Fields Influence Reactivity Patterns and Guide Regioselectivities in α-Ketoglutarate-Dependent Non-heme Iron Dioxygenases

Authors: Sam P de Visser, Gourab Mukherjee, Hafiz Saqib Ali, Chivukula V Sastri

Journal: Acc Chem Res

PubMed ID: 34915695

Doi: 10.1021/acs.accounts.1c00538

Products & Services: Custom Vector Construction

Chlorogenic Acid-Induced Gut Microbiota Improves Metabolic Endotoxemia

Authors: Xiaolin Ye, Yang Liu, Jiajin Hu, Yanyan Gao, Yanan Ma, Deliang Wen