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Inhibiting Chemotherapy Immune Tolerance and Reversing Tumor Microenvironment by Macrophage-Targeted Nanohybrid Systems for Enhancing Tumor Chemo-Immunotherapy

Authors: You-Teng Qin, Zhi-Yong Rao, Jia-Xin An, Shi-Man Zhang, Yu-Zhang Wang, Ting Pan, and Xian-Zheng Zhang

Journal: Advanced Functional Materials

Doi: doi.org/10.1002/adfm.202501954

Products & Services: Recombinant Proteins

Molecular mechanisms of urate transport by the native human URAT1 and its inhibition by anti-gout drugs

Authors: Canrong Wu, Chao Zhang, Sanshan Jin, James Jiqi Wang, Antao Dai, Jiuyin Xu, Heng Zhang, Xuemei Yang, Xinheng He, Qingning Yuan, Wen Hu, Youwei Xu, Mingwei Wang, Yi Jiang, Dehua Yang, H Eric Xu

Journal: Cell Discov

PubMed ID: 11962085

Doi: 10.1038/s41421-025-00779-z

Products & Services: Catalog Peptides

Metabolite-dependent m6A methylation driven by mechanotransduction-metabolism-epitranscriptomics axis promotes bone development and regeneration

Authors: Zhuo Li, Zhengnan Guo, Zhengmeng Yang, Boguang Yang, Yuan Hu, Xian Xie, Zhixian Zong, Zekun Chen, Kunyu Zhang, Pengchao Zhao, Gang Li, Xuefeng Yang, Liming Bian

Journal: Cell Rep

PubMed ID: 40272981

Doi: 10.1016/j.celrep.2025.115611

Products & Services: Peptide Synthesis

The PYRIN domain is required for TLR4-mediated inflammation by PYHIN family members

Authors: Andrea Iannucci, Davide Lacarbonara, Valeria Caneparo, Federica Castiglioni, Andrea Butticè, Stefano Raviola, Chiara Porta, Riccardo Miggiano, Ivan Zanoni, Marisa Gariglio, Marco De Andrea

Journal: iScience

PubMed ID: 40454096

Doi: 10.1016/j.isci.2025.112413

Products & Services: Mutagenesis Services

Synergistic impact of macrolide resistance and H3N2 infection on M. pneumoniae outbreak in children

Authors: Jiali Chen, Yingdan Wang, Juan Cheng, Yunping Ma, Xin Zhang, Xuezhou Bai, Palizhati Rehati, Huashun Cui, Fan Wu, Qiuhui Pan, Jinghe Huang

Journal: Microbiology Spectrum

PubMed ID: 39998323

Doi: 10.1128/spectrum.01844-24

Products & Services: Gene Synthesis

Shigella effector IpaH1.4 subverts host E3 ligase RNF213 to evade antibacterial immunity

Authors: Xindi Zhou, Huijing Zhang, Yaru Wang, Danni Wang, Zhiqiao Lin, Yuchao Zhang, Yubin Tang, Jianping Liu, Yu-Feng Yao, Yixiao Zhang & Lifeng Pan

Journal: Nature Communications

PubMed ID: 40164614

Doi: 10.1038/s41467-025-58432-y

Products & Services: Protein Electrophoresis and Western

Intranasal influenza virus-vectored vaccine offers protection against clade 2.3.4.4b H5N1 infection in small animal models

Authors: Ying Liu, Shaofeng Deng, Shuang Ren, Rachel Chun-Yee Tam, Siwen Liu, Anna Jinxia Zhang, Kelvin Kai-Wang To, Kwok-Yung Yuen, Honglin Chen & Pui Wang

Journal: Nature Communications

PubMed ID: 40169649

Doi: 10.1038/s41467-025-58504-z

Products & Services: Peptide Synthesis

True length of diverse capped RNA sequencing (TLDR-seq): 5′–3′-end sequencing of capped RNAs regardless of 3′-end status

Authors: Jamie Auxillos, Arnaud Stigliani, Christian Skov Vaagensø, William Garland, Adnan Muhammed Niazi, Eivind Valen, Torben Heick Jensen, Albin Sandelin

Journal: Nucleic Acids Research

PubMed ID: 40183637

Doi: 10.1093/nar/gkaf240

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Architecture and conformational dynamics of the BAM-SurA holo insertase complex

Authors: Philippe A Lehner, Morris Degen, Roman P Jakob, Seyed Majed Modaresi, Morgane Callon, Björn M Burmann, Timm Maier, Sebastian Hiller

Journal: SCIENCE ADVANCES

PubMed ID: 40184469

Doi: 10.1126/sciadv.ads6094

Products & Services: Gene Synthesis

A naturally selected αβ T cell receptor binds HLA-DQ2 molecules without co-contacting the presented peptide

Authors: Jia Jia Lim, Claerwen M. Jones, Tiing Jen Loh, Hien Thy Dao, Mai T. Tran, Jason A. Tye-Din, Nicole L. La Gruta & Jamie Rossjohn

Journal: Nature Communications

PubMed ID: 40199885

Doi: 10.1038/s41467-025-58690-w

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