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页码: 70/5233 每页显示数量

Neuron-targeted gene therapy rescues multiple phenotypes of STXBP1-related disorders in mice and is well tolerated in nonhuman primates

Authors: Rangoli Aeran, Annie Tanenhaus, Sheila M S Sears, Nathan J Moerke, Adam Miller, Camille Artur, Yosr Bouhlal, Peter F Bove, Alexander J Diaz de Arce, Saki Shimizu, Jason Le, Keith Place, Dixon Hoffelt, Tselmeg Amarlkhagva, Jennifer Su, Ming Chen, Brooke A Babineau, John McLaughlin, Myat Soe, Warren Macdonald, I Winnie Lin, Dhruv Bole, Kristen M Valentine, Elizabeth Hallam, Puja Dhanota, Serena Liu, Steven A Tan, Ben Zhao, Raghavendra Hosur, Maria Candida Vila, Suresh Poda, Archana Belle, Stephanie Tagliatela

Journal: Molecular Therapy

PubMed ID: 40349107

Doi: 10.1016/j.ymthe.2025.05.011

Import mechanism of peroxisomal proteins with an N-terminal signal sequence

Authors: Michael L Skowyra , Tom A Rapoport

Journal: Nature Cell Biology

PubMed ID: 40346349

Doi: 10.1038/s41556-025-01662-5

Products & Services: Peptide Synthesis

Functional divergence of plant SCAR/WAVE proteins is determined by intrinsically disordered regions

Authors: Sabine Brumm, Aleksandr Gavrin, Matthew Macleod, Guillaume Chesneau, Annika Usländer, Sebastian Schornack

Journal: SCIENCE ADVANCES

PubMed ID: 40397725

Doi: 10.1126/sciadv.adt6107

Products & Services: Gene Synthesis

Graphene oxide enhances aphid resistance in sorghum via the miR319-SbTCP7-SbLOX3 Pathway

Authors: Yannan Shi, Zhiyin Jiao, Jinping Wang, Zhifang Wang, Cheng Chu, Yongchao Guo, Peng Lv, Junfeng Cao

Journal: Plant Biotechnology Journal.

PubMed ID: 40397692

Doi: 10.1111/pbi.70132

Products & Services: Gene Synthesis

A novel, covalent broad-spectrum inhibitor targeting human coronavirus Mpro

Authors: Jing Sun, Deheng Sun, Qi Yang, Dong Wang, Jingjing Peng, Hu Guo, Xiaoyu Ding, Zhao Chen, Bin Yuan, Yan A Ivanenkov, Jinwei Yuan, Bogdan A Zagribelnyy, Yiyun He, Jingyi Su, Ling Wang, Jielin Tang, Zhun Li, Rong Li, Taotao Li, Xiaoyu Hu, Xing Liang, Airu Zhu, Peilan Wei, Yaya Fan, Sang Liu, Jie Zheng, Xin Guan, Alex Aliper, Minglei Yang, Dmitry S Bezrukov, Zhanhong Xie, Victor A Terentiev, Guilin Peng, Daniil A Polykovskiy, Alexander S Malyshev, Maxim N Malkov, Qingsong Zhu, Alán Aspuru-Guzik, Xiao Ding, Xin Cai, Man Zhang, Jingxian Zhao, Nanshan Zhong, Feng Ren, Xinwen Chen, Alex Zhavoronkov, Jincun Zhao

Journal: Nature Communications

PubMed ID: 40374668

Doi: 10.1038/s41467-025-59870-4

Products & Services: Peptide Synthesis

Mechanism of D-type cyclin recognition by the AMBRA1 E3 ligase receptor

Authors: Yang Wang, Ming Liu, Shan Wang, Xinyi Mai, Xi Wang, Fei Teng, Tianrui Lyu, Ming-Yuan Su, Goran Stjepanovic

Journal: SCIENCE ADVANCES

PubMed ID: 40408472

Doi: 10.1126/sciadv.adu8708

Products & Services: Peptide Synthesis

Expanding the σ54-dependent transcription process with orthogonal designs

Authors: Yiheng Liu, Shuyi Cai, Ziyi Zhang, Zhuoting Xie, Chenyue Guo, Yi-Ping Wang, Jianguo Yang

Journal: Nucleic Acids Research

PubMed ID: 40401558

Doi: 10.1093/nar/gkaf442

Products & Services: Gene Synthesis

Hsc70-4: An unanticipated mediator of dsRNA internalization in Drosophila

Authors: Sabrina J Fletcher, Eugenia S Bardossy, Lorena Tomé-Poderti, Thomas Moss, Vanesa Mongelli, Lionel Frangeul, Hervé Blanc, Yann Verdier, Joelle Vinh, Shaeri Mukherjee, Maria-Carla Saleh

Journal: SCIENCE ADVANCES

PubMed ID: 40378201

Doi: 10.1126/sciadv.adv1286

Elucidating the genetic mechanisms governing cytosine base editing outcomes through CRISPRi screens

Authors: Sifeng Gu , Zsolt Bodai , Rachel A Anderson , Hei Yu Annika So , Quinn T Cowan , Alexis C Komor

Journal: Nature Communications

PubMed ID: 40394064

Doi: 10.1038/s41467-025-59948-z

Accurate Mapping of 5-Glyceryl-methylcytosine Using Nanopore Sequencing

Authors: Linting Wang, Baodan He, Zixin Wang, Liting Kang, Jianhuang Xue, Shuanghong Yan

Journal: Anal Chem

PubMed ID: 40314134