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CRISPR/Cas9 Approach to Generate an Auxotrophic BCG Strain for Unmarked Expression of LTAK63 Adjuvant: A Tuberculosis Vaccine Candidate

Authors: Luana Moraes, Monalisa Martins Trentini, Dimitrios Fousteris, Silas Fernandes Eto, Ana Marisa Chudzinski-Tavassi, Luciana Cezar de Cerqueira Leite, Alex Issamu Kanno

Journal: Front Immunol

PubMed ID: 35432328

Doi: 10.3389/fimmu.2022.867195

Products & Services: Synthetic Guide RNA

OsASHL1 and OsASHL2, two members of the COMPASS-like complex, control floral transition and plant development in rice

Authors: Guangxin Zhao, Jingying Wang, Xi Chen, Hanjing Sha, Xin Liu, Yunfei Han, Guankai Qiu, Fantao Zhang, Jun Fang

Journal: J Genet Genomics

PubMed ID: 35306222

Doi: 10.1016/j.jgg.2022.02.026

Products & Services: Catalog Antibodies

Targeting an evolutionarily conserved "E-L-L" motif in the spike protein to develop a small molecule fusion inhibitor against SARS-CoV-2

Authors: Indrani Das Jana, Prabuddha Bhttacharya, Karthick Mayilsamy, Saptarshi Banerjee, Gourab Bhattacharje, Sayan Das, Seemanti Aditya, Anandita Ghosh, Andrew R McGill, Syamanthak Srikrishnan, Amit Kumar Das, Amit Basak, Shyam S Mohapatra, Bala Chandran, Devesh Bhimsaria, Subhra Mohapatra, Arunava Roy, Arindam Mondal

Journal: biorxiv

PubMed ID: 35313575

Doi: 10.1101/2022.03.16.484554

Products & Services: Protein and Antibody Isolation

mRNA-encoded HIV-1 Env trimer ferritin nanoparticles induce monoclonal antibodies that neutralize heterologous HIV-1 isolates in mice

Authors: Zekun Mu, Kevin Wiehe, Kevin O Saunders, Rory Henderson, Derek W Cain, Robert Parks, Diana Martik, Katayoun Mansouri, Robert J Edwards, Amanda Newman, Xiaozhi Lu, Shi-Mao Xia, Amanda Eaton, Mattia Bonsignori, David Montefiori, Qifeng Han, Sravani Venkatayogi, Tyler Evangelous, Yunfei Wang, Wes Rountree, Bette Korber, Kshitij Wagh, Ying Tam, Christopher Barbosa, S Munir Alam, Wilton B Williams, Ming Tian, Frederick W Alt, Norbert Pardi, Drew Weissman, Barton F Haynes

Journal: Cell Rep

PubMed ID: 35294883

Doi: 10.1016/j.celrep.2022.110514

Products & Services: Gene Synthesis

Monomodular Pseudomonas aeruginosa phage JG004 lysozyme (Pae87) contains a bacterial surface-active antimicrobial peptide-like region and a possible substrate-binding subdomain

Authors: Roberto Vázquez, Mateo Seoane-Blanco, Virginia Rivero-Buceta, Susana Ruiz, Mark J van Raaij, Pedro García

Journal: Acta Crystallogr D Struct Biol

PubMed ID: 35362467

Doi: 10.1107/S2059798322000936

Products & Services: Custom Vector Construction

Neddylation is essential for β-catenin degradation in Wnt signaling pathway

Authors: Bojun Wang, Tiantian Wang, Huimin Zhu, Rong Yan, Xinru Li, Chengqian Zhang, Wanyu Tao, Xisong Ke, Piliang Hao, Yi Qu

Journal: Cell Rep

PubMed ID: 35320710

Doi: 10.1016/j.celrep.2022.110538

Products & Services: Plasmid DNA Preparation

TNF-α stimulation enhances the neuroprotective effects of gingival MSCs derived exosomes in retinal ischemia-reperfusion injury via the MEG3/miR-21a-5p axis

Authors: Ziyu Yu, Yuwen Wen, Nan Jiang, Zhidong Li, Jieying Guan, Yingying Zhang, Caibing Deng, Ling Zhao, Song Guo Zheng, Yingting Zhu, Wenru Su, Yehong Zhuo

Journal: Biomaterials

PubMed ID: 35378413

Doi: 10.1016/j.biomaterials.2022.121484

Products & Services: Protein and Antibody Isolation

Downregulation of m A writer complex member METTL14 in bladder urothelial carcinoma suppresses tumor aggressiveness

Authors: Catarina Guimarães-Teixeira, João Lobo, Vera Miranda-Gonçalves, Daniela Barros-Silva, Cláudia Martins-Lima, Sara Monteiro-Reis, José Pedro Sequeira, Isa Carneiro, Margareta P Correia, Rui Henrique, Carmen Jerónimo

Journal: Mol Oncol

PubMed ID: 35048498

Doi: 10.1002/1878-0261.13181

Products & Services: Plasmid DNA Preparation

Robust Pharmacology of Tmod, a Synthetic Dual-Signal Integrator for Cancer Cell Therapy

Authors: Diane Manry, Kristian Bolanos, Breanna DiAndreth, Jee-Young Mock, Alexander Kamb

Journal: Front Immunol

PubMed ID: 35359952

Doi: 10.3389/fimmu.2022.826747

Products & Services: Peptide Synthesis

Current Status and Future Perspectives on MRNA Drug Manufacturing

Authors: Cameron Webb, Shell Ip, Nuthan V Bathula, Petya Popova, Shekinah K V Soriano, Han Han Ly, Burcu Eryilmaz, Viet Anh Nguyen Huu, Richard Broadhead, Martin Rabel, Ian Villamagna, Suraj Abraham, Vahid Raeesi, Anitha Thomas, Samuel Clarke, Euan C Ramsay, Yvonne Perrie, Anna K Blakney

Journal: Mol Pharm

PubMed ID: 35238565

Doi: 10.1021/acs.molpharmaceut.2c00010

Products & Services: Gene Synthesis