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Dual-Modular Hydrogel Microparticles with Precision-Modulation of Inflammatory Microenvironment Dictate Full-Thickness Cartilage Regeneration for Osteoarthritis Repair

Authors: Xinye Chen, Yuanman Yu, Zirui He, Lina Pan, Jing Wang, Changsheng Liu

Journal: Advanced Science

Doi: 10.1002/advs.202504965

Products & Services: Peptide Synthesis

Strategy to overcome a nirmatrelvir resistance mechanism in the SARS-CoV-2 nsp5 protease

Authors: Grace Neilsen, Shuiyun Lan, Ryan L Slack, Zachary C Lorson, Andres Emanuelli Castaner, Rachel Lee, Kristin G Edwards, Huanchun Zhang, Jasper Lee, William A Cantara, Maria E Cilento, Hongwang Zhang, Ramyani De, Franck Amblard, Philip R Tedbury, Karen A Kirby, Raymond F Schinazi, Stefan G Sarafianos

Journal: SCIENCE ADVANCES

PubMed ID: 40479048

Doi: 10.1126/sciadv.adv8875

Products & Services: PCR Cloning and Subcloning

UniClo: scarless hierarchical DNA assembly without sequence constraint

Authors: Carol N Flores-Fernández , Da Lin , Katherine Robins , Chris A O'Callaghan

Journal: Nucleic Acids Research

PubMed ID: 40548934

Doi: 10.1093/nar/gkaf548

Products & Services: PCR Cloning and Subcloning

Novel telomere-targeting dual-pharmacophore dinucleotide prodrugs for anticancer therapy

Authors: Ilgen Mender , Romina Girotti , Sergei Gryaznov

Journal: Nucleic Acids Research

PubMed ID: 40568934

Doi: 10.1093/nar/gkaf591

Products & Services: Protein Electrophoresis and Western

Dynamic ensembles of SARS-CoV-2 N-protein reveal head-to-head coiled-coil-driven oligomerization and phase separation

Authors: Guillem Hernandez, Maria L Martins, Nuno P Fernandes, Tiago Veloso, João Lopes, Tiago Gomes, Tiago N Cordeiro

Journal: Nucleic Acids Research

PubMed ID: 40503686

Doi: 10.1093/nar/gkaf502

In vitro programmable DNA cleavage by a eukaryotic Argonaute

Authors: Guangbo Yan, Xia Li, Longyu Wang, Fei Wang, Siyuan Lv, Xiaolan Yu, Zhongchen Li, Jiakai Cui, Baotong Sun, Jia Hou, Wenqiang Li, Xiaochen Xie, Shuai Zhao, Zhiwei Zhang, Wanping Chen, Yanhong Peng, Yang Liu, Lixin Ma

Journal: Nucleic Acids Research

PubMed ID: 40548933

Doi: 10.1093/nar/gkaf561

Structural Insights into the Assembly of the African Swine Fever Virus Inner Capsid

Authors: Haining Li , Qi Liu , Luyuan Shao , Ye Xiang

Journal: Journal of Virology

PubMed ID: 37191520

Doi: 10.1128/jvi.00268-23

Products & Services: Protein and Antibody Isolation

Enhancement of CRISPR-Cas12a system through universal circular RNA design

Authors: Jiaqi Wang, Wei Zhang, Wentao Li, Qinyuan Xie, Ziyu Zang, Chaoxing Liu

Journal: Cell Reports Methods

PubMed ID: 40527291

Doi: 10.1016/j.crmeth.2025.101076

Products & Services: Molecular Biology Reagents

YAP maintains the dynamics of TDP-43 condensates and antagonizes TDP-43 pathological aggregates

Authors: Jiaqi Zhang, Jiaojiao Hu, Ruogu Liu, Tian Zhou, Xuewei Luo, Peigang Liang, Zaichao Xie, Qinyue Zhao, Yan Chen, Dan Du, Cong Liu, Yiming Zheng, Dan Li, Bo Wang

Journal: Nature Cell Biology

PubMed ID: 40542195

Doi: doi.org/10.1038/s41556-025-01685-y

Products & Services: Protein and Antibody Isolation Protein and Antibody Isolation

RIG-I-Inducing Small Molecules Potently Inhibit HMA-Resistant AML Through Igniting the Overloaded dsRNA Arsenal

Authors: Xueqin Chen 1, Jiaqi Wu 1, Yuntong Li 1, Jiayu Huang 1, Xiangqin Weng 1, Jiale Wu 1, Shujun Xiao 1 2, Huaxin Song 1, Zhengyuan Wang 1, Ni Yan 1, Fangfang Shi 1, Derun Zheng 1 2, Kai Tan 1 2, Hesong Zhang 1, Jingyi Cui 1 2, Wen Wu 1, Wei Wu 3, Sujiang Zhang 1, Min Lu 1

Journal: Advanced Science

PubMed ID: 40568903

Doi: 10.1002/advs.202414477

Products & Services: Catalog Antibodies