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AdpA, a developmental regulator, promotes ε-poly-l-lysine biosynthesis in Streptomyces albulus

Authors: Rui Huang , Honglu Liu , Wanwan Zhao , Siqi Wang , Shufang Wang , Jun Cai , Chao Yang

Journal: Microb Cell Fact

PubMed ID: 35397580

Doi: 10.1186/s12934-022-01785-6

Products & Services: Gene Synthesis Protein and Antibody Isolation

Targeting intrinsically disordered regions facilitates discovery of CaV3.2 inhibitory peptides for AAV-mediated peripheral analgesia

Authors: Seung Min Shin , Justas Lauzadis , Brandon Itson-Zoske , Yongsong Cai 1 , Fan Fan , Gayathri Natarajan , Wai-Meng Kwok , Michelino Puopolo , Quinn H Hogan , Hongwei Yu

Journal: Pain

PubMed ID: 35420557

Doi: 10.1097/j.pain.0000000000002650

Products & Services: Gene Synthesis

Novel sarbecovirus bispecific neutralizing antibodies with exceptional breadth and potency against currently circulating SARS-CoV-2 variants and sarbecoviruses

Authors: Yingdan Wang, Meiqin Liu, Yaping Shen, Yunping Ma, Xiang Li, Yuanyuan Zhang, Mei Liu, Xing-Lou Yang, Jun Chen, Renhong Yan, Die Luan, Yanqun Wang, Ying Chen, Qimin Wang, Haofeng Lin, Yaning Li, Kaiyue Wu, Tongyu Zhu, Jincun Zhao, Hongzhou Lu, Yumei Wen, Shibo Jiang, Fan Wu, Qiang Zhou, Zheng-Li Shi, Jinghe Huang

Journal: Cell Discov

PubMed ID: 35443747

Doi: 10.1038/s41421-022-00401-6

Products & Services: Codon Optimization Protein and Antibody Isolation

Specific knockdown of by CRISPR-CasRx prevents acquired sensorineural hearing loss in mice

Authors: Yang Guo, Lei Han, Shuang Han, Honghai Tang, Shengyi Wang, Chong Cui, Bing Chen, Huawei Li, Yilai Shu

Journal: Mol Ther Nucleic Acids

PubMed ID: 35615000

Doi: 10.1016/j.omtn.2022.04.014

Products & Services: Protein and Antibody Isolation

Immmunoinformatics-based design of a multi-epitope vaccine with CTLA-4 extracellular domain to combat Helicobacter pylori

Authors: Zhenyu Ru, Mingkai Yu, Yuejie Zhu, Zhiqiang Chen, Fengbo Zhang, Zhiqiang Zhang, Jianbing Ding

Journal: FASEB J

PubMed ID: 35294065

Doi: 10.1096/fj.202101538RR

Products & Services: Molecular Biology Tools

p53 alters intracellular Ca signaling through regulation of TRPM4

Authors: Sven Kappel, Daniela Ross-Kaschitza, Barbara Hauert, Karen Rother, Christine Peinelt

Journal: Cell Calcium

PubMed ID: 35500522

Doi: 10.1016/j.ceca.2022.102591

Products & Services: Protein and Antibody Isolation

Partitioning defective 6 homolog alpha (PARD6A) promotes epithelial-mesenchymal transition via integrin β1-ILK-SNAIL1 pathway in ovarian cancer

Authors: Ziwen Lu, Sirui Yuan, Lingling Ruan, Zhigang Tu, Hanqing Liu

Journal: Cell Death Dis

PubMed ID: 35379775

Doi: 10.1038/s41419-022-04756-2

Products & Services: Catalog Peptides

Potent TRIM21 and complement-dependent intracellular antiviral immunity requires the IgG3 hinge

Authors: Stian Foss, Alexandra Jonsson, Maria Bottermann, Ruth Watkinson, Heidrun E Lode, Martin B McAdam, Terje E Michaelsen, Inger Sandlie, Leo C James, Jan Terje Andersen

Journal: Sci Immunol

PubMed ID: 35486676

Doi: 10.1126/sciimmunol.abj1640

Products & Services: Custom Vector Construction

Drug-Repurposing Screening Identified Tropifexor as a SARS-CoV-2 Papain-like Protease Inhibitor

Authors: Chunlong Ma, Yanmei Hu, Yuyin Wang, Juliana Choza, Jun Wang

Journal: ACS Infect Dis

PubMed ID: 35404564

Doi: 10.1021/acsinfecdis.1c00629

Products & Services: ORF cDNA Clones/MolecularCloud

Dual Role of HIV-1 Envelope Signal Peptide in Immune Evasion

Authors: Chitra Upadhyay, Priyanka Gadam Rao, Roya Feyznezhad