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Alleviation of Hepatic Steatosis by 4-azidophlorizin via the Degradation of Geranylgeranyl Diphosphate Synthase by the Ubiquitin-Proteasome Pathway in Vivo and in Vitro

Authors: Juan Ye, Yaling Qi, Jiao Chen, Shihu Zhang, Boyuan Liu, Yinjuan Zhao, Xianwen Yuan, Qi Cheng, Yang Yang, Furong Zhang, Hongliang Gao, Haoran Wang, Jing Wu, Feng Zhu, Chaojun Li, Peng Cao, Bin Xue

Journal: Adv Biol (Weinh)

PubMed ID: 36599632

Doi: 10.1002/adbi.202200150

Products & Services: Protein and Antibody Isolation

Human mitochondria require mtRF1 for translation termination at non-canonical stop codons

Authors: Annika Krüger, Cristina Remes, Dmitrii Igorevich Shiriaev, Yong Liu, Henrik Spåhr, Rolf Wibom, Ilian Atanassov, Minh Duc Nguyen, Barry S Cooperman, Joanna Rorbach

Journal: Nat Commun

PubMed ID: 36596788

Doi: 10.1038/s41467-022-35684-6

Products & Services: Molecular Biology Reagents

Functional Impact of a Cancer-Related Variant in Human Δ1-Pyrroline-5-Carboxylate Reductase 1

Authors: Oseeyi I Daudu , Kaylen R Meeks , Lu Zhang , Javier Seravalli , John J Tanner , Donald F Becker

Journal: ACS Omega .

PubMed ID: 36713721

Doi: 10.1021/acsomega.2c07788

Products & Services: Mutagenesis Services

Enhancer architecture and chromatin accessibility constrain phenotypic space during Drosophila development

Authors: Rafael Galupa, Gilberto Alvarez-Canale, Noa Ottilie Borst, Timothy Fuqua, Lautaro Gandara, Natalia Misunou, Kerstin Richter, Mariana R P Alves, Esther Karumbi, Melinda Liu Perkins, Tin Kocjan, Christine A Rushlow, Justin Crocker

Journal: Dev Cell

PubMed ID: 36626871

Doi: 10.1016/j.devcel.2022.12.003

Products & Services: Molecular Biology Reagents Gene Synthesis

YAP1 suppression inhibits autophagy and improves the efficacy of anti-PD-1 immunotherapy in hepatocellular carcinoma

Authors: Yuting Gao, Qing Peng, Shenghao Li, Kangning Zheng, Yi Gong, Yu Xue, Yiwei Liu, Junlan Lu, Yuman Zhang, Xinli Shi

Journal: Exp Cell Res

PubMed ID: 36693491

Doi: 10.1016/j.yexcr.2023.113486

Products & Services: Protein and Antibody Isolation

Author Correction: Structure basis for inhibition of SARS-CoV-2 by the feline drug GC376

Authors: Xiao-Dong Luan, Bin-Xian Chen, Wei-Juan Shang, Wan-Chao Yin, Ye Jin, Lei-Ke Zhang, H Eric Xu, Shu-Yang Zhang

Journal: Acta Pharmacol Sin

PubMed ID: 35948753

Doi: 10.1038/s41401-022-00964-w

Products & Services: Protein and Antibody Isolation

A covalent opsonization approach to enhance synthetic immunity against viral escape variants

Authors: Eden Kapcan, Anthony F Rullo

Journal: Cell Rep Phys Sci

PubMed ID: 36741337

Doi: 10.1016/j.xcrp.2023.101258

Products & Services: Molecular Biology Reagents

Ensemble-based, high-throughput virtual screening of potential inhibitor targeting putative farnesol dehydrogenase of Metisa plana (Lepidoptera: Psychidae)

Authors: Anis Nadyra Zifruddin, Mohamad Ariff Mohamad Yusoff, Nur Syatila Abd Ghani, Nor Azlan Nor Muhammad, Kok Wai Lam, Maizom Hassan

Journal: Comput Biol Chem

PubMed ID: 36645937

Doi: 10.1016/j.compbiolchem.2023.107811

Products & Services: DNA Sequencing

A single, improbable B cell receptor mutation confers potent neutralization against cytomegalovirus

Authors: Jennifer A Jenks, Sharmi Amin, Madeline R Sponholtz, Amit Kumar, Daniel Wrapp, Sravani Venkatayogi, Joshua J Tu, Krithika Karthigeyan, Sarah M Valencia, Megan Connors, Melissa J Harnois, Bhavna Hora, Eric Rochat, Jason S McLellan, Kevin Wiehe, Sallie R Permar

Journal: PLoS Pathog

PubMed ID: 36662906

Doi: 10.1371/journal.ppat.1011107

Products & Services: Recombinant Antibody Expression

The neoepitope of the complement C5b-9 Membrane Attack Complex is formed by proximity of adjacent ancillary regions of C9

Authors: Charles Bayly-Jones, Bill H T Ho, Corinna Lau, Eleanor W W Leung, Laura D'Andrea, Christopher J Lupton, Susan M Ekkel, Hariprasad Venugopal, James C Whisstock, Tom E Mollnes, Bradley A Spicer, Michelle A Dunstone

Journal: Commun Biol

PubMed ID: 36639734

Doi: 10.1038/s42003-023-04431-y

Products & Services: DNA Sequencing