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The crystal structure of coronavirus RBD-TMPRSS2 complex provides basis for the discovery of therapeutic antibodies

Authors: Zhuoqian Zhao, Qi Yang, Xiaoce Liu, Mengfei Li, Yinkai Duan, Mingjuan Du, Anqi Zhou, Huanzhen Liu, Yujia He, Wei Wang, Yuchi Lu, Xiaoyu Zhang, Haofeng Wang, Xiuna Yang, Hongkai Zhang, Xinwen Chen, Zihe Rao, Haitao Yang

Journal: nature COMMUNICATION

PubMed ID: 40681508

Doi: 10.1038/s41467-025-62023-2

Products & Services: Protein and Antibody Isolation

Metabolic modulation-driven self-reinforcing pyroptosis-STING nanoadjuvant for potentiated metalloimmunotherapy

Authors: Linzhu Zhang, Di Wang, Yiming Liu, Nailin Yang, Shumin Sun, Chunjie Wang, Duo Wang, Jihu Nie, Juan Qin, Lei Zhang, Liang Cheng, Haidong Zhu

Journal: Bioactive Materials

PubMed ID: 40792115

Doi: 10.1016/j.bioactmat.2025.07.040

Products & Services: Protein and Antibody Isolation

Chromosome-specific oligo-painting provides insights into the cytogenetic basis of karyotypic stasis in paleo-allotetraploid Cucurbita

Authors: Qinzheng Zhao, Yulin Bai, Yuhui Wang, Chunyan Cheng, Xiaqing Yu, Qunfeng Lou, Jinfeng Chen

Journal: Horticulture research

Doi: doi.org/10.1093/hr/uhaf179

Products & Services: Oligo pool

Identifying and characterizing a missing peroxin-PEX8-in Arabidopsis thaliana

Authors: Gabrielle C Buck, Ashley D Weeks, Niamh E Ordner, Bonnie Bartel

Journal: Plant Cell

PubMed ID: 40577590

Doi: 10.1093/plcell/koaf166

Products & Services: Protein Electrophoresis and Western

High-fidelity DNA polymerase for DNA-based digital Information Storage

Authors: Xutong Liu, Kai Wen, Enyang Yu, Qixuan Zhao, Haoran Fu, Jingxuan Zhu, Haobo Han, Quanshun Li

Journal: Small Methods

PubMed ID: 40665906

Doi: 10.1002/smtd.202500817

Products & Services: Oligo pool

Metabotropic glutamate receptor 4-mediated glutamatfergic signaling reshapes the tumor microenvironment by regulating dendritic cell maturation

Authors: Xiaoman Ju, Eva Maria Putz, Yaqi Liu, Dongchen Yuan, Guowei Sun, Stephane Koda, Zhuo Fu, Simin Shao, Chunrong Tong, Biping Deng, Jing Hu, Juming Yan

Journal: Nature Communications

PubMed ID: 40593670

Doi: 10.1038/s41467-025-60922-y.

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CRISPRi screen identifies FprB as a synergistic target for gallium therapy in Pseudomonas aeruginosa

Authors: Yu Zhang, Tingting Zhang, Xue Xiao, Yejun Wang, Adam Kawalek, Jinzhao Ou, Anmin Ren, Wenhao Sun, Vincent de Bakker, Yujie Liu, Yuelong Li, Liang Yang, Liang Ye, Ning Jia, Jan-Willem Veening, Xue Liu

Journal: Nature Communications

PubMed ID: 40595632

Doi: 10.1038/s41467-025-61208-z

Products & Services: Oligo pool

DRAM1 promotes the stability of lysosomal VAMP8 to enhance autolysosome formation and facilitates the extravasation

Authors: Rui Zhang, Xin Zhang, Hua Bai, Qiuyu Cheng, Xia Yao, Shi Li, Vincenzo Torraca, Chaojun Yan, Xueying Dong, Siyi Miao, Xueyuan Hu, Yeping Yu, Yueyan Wu, Hongfei Tan, Xin Chen, Shicheng Liu, Hao Lyu, Shuai Xiao, Dong Guo, Qi Zhang, Xing-Zhen Chen, Zhiyin Song, Cefan Zhou, Jingfeng Tang

Journal: Nature Communications

PubMed ID: 40595569

Doi: 10.1038/s41467-025-60887-y

Induction of lung mucosal immunity by a next-generation inhaled aerosol COVID-19 vaccine: an open-label, multi-arm phase 1 clinical trial

Authors: Mangalakumari Jeyanathan, Sam Afkhami, Michael R D'Agostino, Imran Satia, Dominik K Fritz, Kate Miyasaki, Jann C Ang, Anna Zganiacz, Karen J Howie, Marilyn Swinton, Emilio Aguirre, Michael B Zheng, Natallia Kazhdan, Anna Dvorkin-Gheva, Lawrence Mbuagbaw, Maria Fe C Medina, Nermin Diab, Danica L Brister, Gail M Gauvreau, Brian D Lichty, Matthew S Miller, Fiona Smaill, Zhou Xing

Journal: Nature Communications

PubMed ID: 40603330

Doi: 10.1038/s41467-025-60726-0

Products & Services: Codon Optimization

PPP2R1A mutations portend improved survival after cancer immunotherapy

Authors: Yibo Dai, Anne Knisely, Mitsutake Yano, Minghao Dang, Emily M Hinchcliff, Sanghoon Lee, Annalyn Welp, Manoj Chelvanambi, Matthew Lastrapes, Heng Liu, Zhe Yuan, Chen Wang, Hao Nie, Stephanie Jean, Luis J Montaner, Jiakai Hou, Ami Patel, Shrina Patel, Bryan Fellman, Ying Yuan, Baohua Sun, Renganayaki Krishna Pandurengan, Edwin Roger Parra Cuentas, Joseph Celestino, Yan Liu, Jinsong Liu, R Tyler Hillman, Shannon N Westin, Anil K Sood, Pamela T Soliman, Aaron Shafer, Larissa A Meyer, David M Gershenson, David Vining, Dhakshinamoorthy Ganeshan, Karen Lu, Jennifer A Wargo, Weiyi Peng, Rugang Zhang, Linghua Wang, Amir A Jazaeri

Journal: Nature

PubMed ID: 40604275

Doi: 10.1038/s41586-025-09203-8

Products & Services: Gene Synthesis