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Localized Delivery of the mRNAs Encoding CD47 Inhibitor and Interleukins 12, 15, and 21 Elicits Robust Antitumor Immunity

Authors: Tao Jiang, Shuaiyang Jing, Haojun Li, Bao Xiao, Jiahui Jin, Xiu Sun, Juan Wang, Jing Liang, Tongze Cai, Huili Hu, Meilan Wei, Xuanrui Zhong, Yang Ji, Peng George Wang, Jianlong Zhou

Journal: Advanced Science

PubMed ID: 40652522

Doi: 10.1002/advs.202417205

Products & Services: PCR Cloning and Subcloning

Regulating the N-oxidation selectivity of P450BM3 monooxygenases for N-heterocycles through computer-assisted structure-guided design

Authors: Liu Yang, Zhongji Pu, Jianping Wu, Xiaofeng Liu, Zhe Wang, Haoran Yu, Liuwei Wang, Yan Meng, Gang Xu, Lirong Yang, Wenlong Zheng

Journal: Nature Communications

PubMed ID: 40659637

Doi: 10.1038/s41467-025-61773-3

Products & Services: Protein Electrophoresis and Western

Regulation of inflammatory responses by pH-dependent transcriptional condensates

Authors: Zhongyang Wu, Scott D Pope, Nasiha S Ahmed, Diana L Leung, Yu Hong, Stephanie Hajjar, Cathleen Krabak, Zhe Zhong, Krishnan Raghunathan, Qiuyu Yue, Diya M Anand, Elizabeth B Kopp, Daniel Okin, Weiyi Ma, Ivan Zanoni, Jonathan C Kagan, Jay R Thiagarajah, Diana C Hargreaves, Ruslan Medzhitov, Xu Zhou

Journal: Cell

PubMed ID: 40680734

Doi: 10.1016/j.cell.2025.06.033

Products & Services: Gene Synthesis

Single-dose avian influenza A(H5N1) Clade 2.3.4.4b hemagglutinin-Matrix-M® nanoparticle vaccine induces neutralizing responses in nonhuman primates

Authors: Nita Patel, Asma Rehman, Jessica F Trost, Rhonda Flores, Zach Longacre, Mimi Guebre-Xabier, Haixia Zhou, Bin Zhou, Kelsey Jacobson, Desheng Jiang, Xiaoyun Bai, Rafia Khatoon, Thomas Kort, James Norton, M Madhangi, Melinda Hersey, Ann M Greene, Filip Dubovsky, Gale Smith

Journal: Nature Communications

PubMed ID: 40681543

Doi: 10.1038/s41467-025-61964-y

Products & Services: Gene Synthesis

Potentiating the Efficacy of mRNA Vaccines through NIR-II Imaging-Guided Precise Vaccination

Authors: Mengfei Li, Xue Zheng, Xinyang Yu, Shaolong Qi, Shoujun Zhu, Guocan Yu, Songling Zhang

Journal: Advanced Science

PubMed ID: 40681479

Doi: 10.1002/advs.202413014

Products & Services: Peptide Synthesis

Remolding Microenvironmental Homeostasis for Enhancing Regenerative Hypertrophic Scar Treatment Based on Functionalized Microneedles

Authors: Shengjie Jiang, Jialiang Zhou, Liyun Wang, Xin Liu, Jiaming Sun, Yu Zhuang, Li Yu, Haiyan Li, Dejian Li, Zhaoyong Zou, Zhen Gao, Kaili Lin

Journal: Interdisciplinary Materials

Doi: doi.org/10.1002/idm2.70000

Products & Services: Protein Electrophoresis and Western

A novel and sensitive AuNPs/tetracystein-glucose dehydrogenase(GDH)/ screen-printed electrode(SPE)-based electrochemical glucose biosensor

Authors: Ting Zhang , Danni Ma , Fuman Cai

Journal: Microchemical Journal

Doi: doi.org/10.1016/j.microc.2025.114629

Products & Services: Codon Optimization Gene Synthesis Molecular Biology Reagents

Discovery of PXR Antagonist MI891 and PXR Degrader MI1013 and Their Roles in Hepatic Gene Regulation

Authors: Rajamanikkam Kamaraj, Ivana Mejdrová, Maria Krutakova, Tomas Smutny, Kryštof Škach, Klara Dohnalova, Lucie Smutna, Dharani Sai Sreekanth Nellore, Jan Dusek, Karel Chalupsky, Jana Hricová, Thales Kronenberger, Aaron Stahl, Markus Templin, Albert Braeuning, Radim Nencka, Petr Pavek

Journal: Journal of Medicinal Chemistry

PubMed ID: 40650588

Doi: 10.1021/acs.jmedchem.4c03134

Products & Services: Custom Vector Construction

Lysosome-mediated aggregation of galactose-deficient IgA1 with transferrin receptor 1 links to IgA nephropathy

Authors: Meijun Si, Jingpeng Fu, Mengting Fang, Yunfei Lu, Junxuan Huang, Haojie Li, Peiyi Wang, Maofu Liao, Jian Zhu, Peiyao Li, Wenzhao Zhong, Zhifei Guo, Wei Yang, Zhiming Ye, Hongli Hu, Xueqing Yu

Journal: Nature Communications

PubMed ID: 40593574

Doi: 10.1038/s41467-025-60819-w

Products & Services: Protein and Antibody Isolation

Mice with a diverse human T cell receptor repertoire selected on multiple HLA class I molecules

Authors: Arunraj Dhamodaran, Xiaojing Chen, Niklas Fellmer, Deepti Agrawal, Eric Danner, Ralf Kühn, Thomas Blankenstein

Journal: Nature Communications

PubMed ID: 40593800

Doi: 10.1038/s41467-025-61306-y

Products & Services: Peptide Synthesis