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Discovery of PXR Antagonist MI891 and PXR Degrader MI1013 and Their Roles in Hepatic Gene Regulation
Authors: Rajamanikkam Kamaraj, Ivana Mejdrová, Maria Krutakova, Tomas Smutny, Kryštof Škach, Klara Dohnalova, Lucie Smutna, Dharani Sai Sreekanth Nellore, Jan Dusek, Karel Chalupsky, Jana Hricová, Thales Kronenberger, Aaron Stahl, Markus Templin, Albert Braeuning, Radim Nencka, Petr Pavek
Journal: Journal of Medicinal Chemistry
PubMed ID: 40650588
Doi: 10.1021/acs.jmedchem.4c03134
Products & Services: Custom Vector Construction   
Microtubule association induces a Mg-free apo-like ADP pre-release conformation in kinesin-1 that is unaffected by its autoinhibitory tail
Authors: J Atherton, M S Chegkazi, M Leusciatti, M Di Palma, E Peirano, L S Pozzer, M V A Meli, S Pasqualato, T Foran, G Morra, R A Steiner
Journal: Nature Communications
PubMed ID: 40617823
Doi: 10.1038/s41467-025-61498-3
Products & Services: Mammalian Expression   
Continuous in situ synthesis of a complete set of tRNAs sustains steady-state translation in a recombinant cell-free system
Authors: Fanjun Li , Amogh Kumar Baranwal , Sebastian J Maerkl
Journal: Nature Communications
PubMed ID: 40617857
Doi: 10.1038/s41467-025-61671-8
Products & Services: Gene Synthesis   
Structural-functional characterization of the MIRO1-TRAK1 complex
Authors: Erika E Ravitch, Elana E Baltrusaitis, Tania A Perez, Kyle R Barrie, Adam R Fenton, Erika L F Holzbaur, Roberto Dominguez
Journal: Nature Communications
PubMed ID: 40615373
Doi: 10.1038/s41467-025-61174-6
Products & Services: Bacterial Expression   
Precision-edited histone tails disrupt polycistronic gene expression controls in trypanosomes
Authors: Markéta Novotná, Michele Tinti, Joana R C Faria, David Horn
Journal: Nature Communications
PubMed ID: 40615444
Doi: 10.1038/s41467-025-61480-z
Products & Services: PCR Cloning and Subcloning   
Subversion of mRNA degradation pathways by EWSR1::FLI1 represents a therapeutic vulnerability in Ewing sarcoma
Authors: Bartimée Galvan, Loïc Ongena, Jonathan Bruyr, Gregory Fettweis, Eva Lucarelli, Arnaud Lavergne, Emeline Mariavelle, Tina M O'Grady, Zahrat El Oula Hassoun, Margaux Claes, Laurence Dubois, Kevin A W Lee, Véronique Kruys, Cyril Gueydan, Jules Durand, Eric Hervouet, Florian H Geyer, Ana Banito, Roland Imle, Lianghao Mao, Ashok K Jayavelu, Thomas G P Grünewald, Florencia Cidre-Aranaz, Jean-Claude Twizere, Franck Dequiedt
Journal: Nature Communications
PubMed ID: 40664627
Doi: 10.1038/s41467-025-61725-x
Products & Services: Custom Vector Construction   
Myosin-dependent short actin filaments contribute to peripheral widening in developing stereocilia
Authors: Xiayi Liao, Chun-Yu Tung, Jocelyn F Krey, Ghazaleh Behnammanesh, Joseph A Cirilo Jr, Mert Colpan, Christopher M Yengo, Peter G Barr-Gillespie, Jonathan E Bird, Benjamin J Perrin
Journal: Nature Communications
PubMed ID: 40593742
Doi: 10.1038/s41467-025-60976-y
Products & Services: Gene Synthesis   
Pol θ-mediated end-joining uses microhomologies containing mismatches
Authors: Yuzhen Li, Ngoc K Dang, Wei He, Mark Returan, Denisse Carvajal-Maldonado, Adele T Guerin, Han Xu, Bin Liu, Richard D Wood
Journal: Nature Communications
PubMed ID: 40603872
Doi: 10.1038/s41467-025-61258-3
Products & Services: Codon Optimization   
FAF2 is a bifunctional regulator of peroxisomal homeostasis and saturated lipid responses
Authors: Choah Kim, Katlyn R Gabriel, Dylan Boone, Matthew R Brown, Katherine Oppenheimer, Maria Kost-Alimova, Juan Lorenzo B Pablo, Anna Greka
Journal: SCIENCE ADVANCES
PubMed ID: 40601736
Doi: 10.1126/sciadv.adu9104
Products & Services: Lentivirus Packaging   
Single-cell RNA sequencing and PANDORA-seq reveal the pivotal role of piRNA in heat stress-induced testicular injury
Authors: Mailin Gan, Jianfeng Ma, Yuhang Lei, Yiting Yang, Yuheng Pan, Shuang Wu, Siyu Chen, Jiaxin Li, Linyuan Shen, Li Zhu
Journal: International Journal of Biological Macromolecules
PubMed ID: 40609925
Doi: 10.1016/j.ijbiomac.2025.145674
Products & Services: Protein and Antibody Isolation   
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