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Safety and immunogenicity of intranasal parainfluenza virus type 5 (PIV5)-vectored COVID-19 vaccine in adults and teens in an open-label phase 1 trial

Authors: Paul Spearman, Hong Jin, Peng Xiao, Kristeene Knopp, Henry Radziewicz, Marinka Tellier, Sasha E Larsen, Bryan J Berube, Xiao Song, Jamie Kidd, Karnail Singh, Zhuo Li, Maria Cristina Gingerich, Samuel Wu, Susan P John, Angela Branche, Ann R Falsey, Rhea Coler, Francois J Villinger, Biao He

Journal: SCIENCE ADVANCES

PubMed ID: 40614182

Doi: 10.1126/sciadv.adw0896

Products & Services: Peptide Library Services

The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI

Authors: Benjamin Bourgeois, Emil Spreitzer, Daniel Platero-Rochart, Margret Paar, Qishun Zhou, Sinem Usluer, Peter L J de Keizer, Boudewijn M T Burgering, Pedro A Sánchez-Murcia, Tobias Madl

Journal: Nature Communications

PubMed ID: 40593617

Doi: 10.1038/s41467-025-60844-9

Products & Services: Bacterial Expression

Pericyte pannexin1 controls cerebral capillary diameter and supports memory function

Authors: Sandra Mai-Morente, Eugenia Isasi, Alberto Rafael, Gonzalo Budelli, Silvia Olivera-Bravo, Nathalia Vitureira, Verónica Abudara

Journal: Nature Communications

PubMed ID: 40610448

Doi: 10.1038/s41467-025-61312-0

Products & Services: Peptide Synthesis

Oropouche virus infects human trophoblasts and placenta explants

Authors: Christina J Megli, Rebecca K Zack, Jackson J McGaughey, Ryan M Hoehl, Taylor Snisky, Amy L Hartman, Cynthia M McMillen

Journal: Nature Communications

PubMed ID: 40593852

Doi: 10.1038/s41467-025-61138-w

Products & Services: Monoclonal Antibody Services

An adaptive peptide-binding site in ubiquitin receptor hRpn13 revealed by structural studies

Authors: Bakar Hassan, Monika Chandravanshi, Martin Y Ng, Hitendra Negi, Brice A P Wilson, Kylie J Walters

Journal: Nature Communications

PubMed ID: 40595513

Doi: 10.1038/s41467-025-60843-w

Products & Services: Peptide Synthesis

Tumor site-directed A1R expression enhances CAR T cell function and improves efficacy against solid tumors

Authors: Kevin Sek, Amanda X Y Chen, Thomas Cole, Jesse D Armitage, Junming Tong, Kah Min Yap, Isabelle Munoz, Phoebe A Dunbar, Shiyi Wu, Marit J van Elsas, Olivia Hidajat, Christina Scheffler, Lauren Giuffrida, Melissa A Henderson, Deborah Meyran, Fernando Souza-Fonseca-Guimaraes, Dat Nguyen, Yu-Kuan Huang, Maria N de Menezes, Emily B Derrick, Cheok Weng Chan, Kirsten L Todd, Jack D Chan, Jasmine Li, Junyun Lai, Emma V Petley, Sherly Mardiana, Anthony Bosco, Jason Waithman, Ian A Parish, Christina Mølck, Gregory D Stewart, Lev Kats, Imran G House, Phillip K Darcy, Paul A Beavis

Journal: Nature Communications

PubMed ID: 40610421

Doi: 10.1038/s41467-025-59021-9

Single-cell RNA sequencing and PANDORA-seq reveal the pivotal role of piRNA in heat stress-induced testicular injury

Authors: Mailin Gan, Jianfeng Ma, Yuhang Lei, Yiting Yang, Yuheng Pan, Shuang Wu, Siyu Chen, Jiaxin Li, Linyuan Shen, Li Zhu

Journal: International Journal of Biological Macromolecules

PubMed ID: 40609925

Doi: 10.1016/j.ijbiomac.2025.145674

Products & Services: Protein and Antibody Isolation

A novel and sensitive AuNPs/tetracystein-glucose dehydrogenase(GDH)/ screen-printed electrode(SPE)-based electrochemical glucose biosensor

Authors: Ting Zhang , Danni Ma , Fuman Cai

Journal: Microchemical Journal

Doi: doi.org/10.1016/j.microc.2025.114629

Products & Services: Codon Optimization Gene Synthesis Molecular Biology Reagents

Discovery of PXR Antagonist MI891 and PXR Degrader MI1013 and Their Roles in Hepatic Gene Regulation

Authors: Rajamanikkam Kamaraj, Ivana Mejdrová, Maria Krutakova, Tomas Smutny, Kryštof Škach, Klara Dohnalova, Lucie Smutna, Dharani Sai Sreekanth Nellore, Jan Dusek, Karel Chalupsky, Jana Hricová, Thales Kronenberger, Aaron Stahl, Markus Templin, Albert Braeuning, Radim Nencka, Petr Pavek

Journal: Journal of Medicinal Chemistry

PubMed ID: 40650588

Doi: 10.1021/acs.jmedchem.4c03134

Products & Services: Custom Vector Construction

Subversion of mRNA degradation pathways by EWSR1::FLI1 represents a therapeutic vulnerability in Ewing sarcoma

Authors: Bartimée Galvan, Loïc Ongena, Jonathan Bruyr, Gregory Fettweis, Eva Lucarelli, Arnaud Lavergne, Emeline Mariavelle, Tina M O'Grady, Zahrat El Oula Hassoun, Margaux Claes, Laurence Dubois, Kevin A W Lee, Véronique Kruys, Cyril Gueydan, Jules Durand, Eric Hervouet, Florian H Geyer, Ana Banito, Roland Imle, Lianghao Mao, Ashok K Jayavelu, Thomas G P Grünewald, Florencia Cidre-Aranaz, Jean-Claude Twizere, Franck Dequiedt

Journal: Nature Communications

PubMed ID: 40664627

Doi: 10.1038/s41467-025-61725-x

Products & Services: Custom Vector Construction