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E. coli-mediated expedient biosynthesis of biotin-labeled ubiquitin probe enables activity-based profiling of deubiquitinases in cytoplasmic and nuclear compartments

Authors: Shuai Peng, Shaowen Wang, Xiaotong Liu, Hongrui Xu, Guoqiang Xu, Jia-bin Li

Journal: Chinese Chemical Letters

Doi: 10.1016/j.cclet.2025.111760

Products & Services: Codon Optimization Gene Synthesis PCR Cloning and Subcloning

Viral evolution prediction identifies broadly neutralizing antibodies to existing and rospective SARS-CoV-2 variants

Authors: Fanchong Jian, Anna Z Wec, Leilei Feng, Yuanling Yu, Lei Wang, Peng Wang, Lingling Yu, Jing Wang, Jacob Hou, Daniela Montes Berrueta, Diana Lee, Tessa Speidel, LingZhi Ma, Thu Kim, Ayijiang Yisimayi, Weiliang Song, Lu Liu, Sijie Yang, Xiao Niu, Tianhe Xiao, Ran An, Yao Wang, Fei Shao, Youchun Wang, Simone Pecetta, Xiangxi Wang, Laura M Walker, Yunlong Cao

Journal: Nature microbiology

PubMed ID: 40494884

Doi: 10.1038/s41564-025-02030-7

Products & Services: Gene Synthesis Codon Optimization

14-3-3 binding maintains the Parkinson’s associated kinase LRRK2 in an inactive state

Authors: Juliana A Martinez Fiesco, Alexandra Beilina, Astrid Alvarez de la Cruz, Ning Li, Riley D Metcalfe, Mark R Cookson, Ping Zhang

Journal: Nature Communications

PubMed ID: 40764514

Doi: 10.1038/s41467-025-62337-1.

Products & Services: Codon Optimization

Structural basis of fast N-type inactivation in Kv channels

Authors: Xiao-Feng Tan, Ana I Fernández-Mariño, Yan Li, Tsg-Hui Chang, Kenton J Swartz

Journal: Nature

PubMed ID: 40770100

Doi: 10.1038/s41586-025-09339-7

Products & Services: Peptide Synthesis

A rapid, simple, and economical method for the isolation of ribosomes and translational machinery for structural and functional studies

Authors: Jessey Erath, Danielle Kemper, Elisha Mugo, Alex Jacoby, Elizabeth Valenzuela, Courtney F Jungers, Wandy L Beatty, Yaser Hashem, Marko Jovanovic, Sergej Djuranovic, Slavica Pavlovic Djuranovic

Journal: Nature Communications

PubMed ID: 40764614

Doi: 10.1038/s41467-025-62314-8.

Products & Services: CRISPR Cell Lines

POSTN-Mediated Interplay of M1 Polarized Macrophage with Tendon-Derived Stem Cells to Drive Traumatic Heterotopic Ossification Formation through PTK7/ATK Signaling?

Authors: Hang Liu, Xinyue Li, Mengyi Li, Ziyang Sun, Xu Wang, Juehong Li, Binbin Xu, Qian Chen, Cunyi Fan, Hongjiang Ruan

Journal: Advanced Science

PubMed ID: 40823759

Doi: 10.1002/advs.202507951

Products & Services: Custom Vector Construction

Structural convergence and water-mediated substrate mimicry enable broad neuraminidase inhibition by human antibodies

Authors: Julia Lederhofer, Andrew J Borst, Lam Nguyen, Rebecca A Gillespie, Connor J Williams, Emma L Walker, Julie E Raab, Christina Yap, Daniel Ellis, Adrian Creanga, Hyon-Xhi Tan, Thi H T Do, Michelle Ravichandran, Adrian B McDermott, Valerie Le Sage, Sarah F Andrews, Barney S Graham, Adam K Wheatley, Douglas S Reed, Neil P King, Masaru Kanekiyo

Journal: Nature Communications

PubMed ID: 40750617

Doi: 10.1038/s41467-025-62339-z.

Products & Services: Custom Vector Construction

An Apple Susceptibility-Related LRR Receptor-Like Kinase MdRLKT21 Activates Plant Immunity by Hijacking a Trans-Kingdom Fungal microRNA-Like RNA

Authors: Mingliang Lei, Jian Zhang, Jie Wang, Chengyu Gao, Yanting He, Runze Tian, Hao Feng, Lili Huang

Journal: Advanced Science

PubMed ID: 40755370

Doi: 10.1002/advs.202417426

Identification of distinct epitopes in dipeptidyl peptidase-4 inhibitor-associated bullous pemphigoid

Authors: Shoko Mai https://orcid.org/0000-0001-5468-6851, Yosuke Mai https://orcid.org/0000-0001-6356-7192, Inkin Ujiie https://orcid.org/0000-0002-7931-949X, Kentaro Izumi https://orcid.org/0000-0001-8221-9644, Ken Natsuga https://orcid.org/0000-0003-3865-6366, Wataru Nishie https://orcid.org/0000-0002-0486-9112, and Hideyuki Ujiie

Journal: SCIENCE ADVANCES

PubMed ID: 40749047

Doi: 10.1126/sciadv.adv9423

Products & Services: Custom Vector Construction

High-throughput investigation of cyclin docking interactions reveals the complexity of motif binding determinants

Authors: Mihkel Örd, Matthew J Winters, Mythili S Subbanna, Natàlia de Martín Garrido, Victoria I Cushing, Johanna Kliche, Caroline Benz, Ylva Ivarsson, Basil J Greber, Peter M Pryciak, Norman E Davey

Journal: Nature Communications

PubMed ID: 40817109

Doi: 10.1038/s41467-025-62765-z.

Products & Services: Peptide Synthesis