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A spacer design strategy for CRISPR-Cas12f1 with single-nucleotide polymorphism mutation resolution capability and its application in the mutations diagnosis of pathogens

Authors: Panqi Gao, Maoyi Yang, Yi Chen, Jun Yan, Miaomiao Han, Haijun Deng, Keli Qian, Jiandong Yang, Yaoqin Lu, Ling Zhou, Ailong Huang, Xiaosong Li, Wanyan Deng, Quanxin Long

Journal: J Med Virol

PubMed ID: 37855689

Doi: 10.1002/jmv.29189

Products & Services: Protein and Antibody Isolation

A novel recombinant S-based subunit vaccine induces protective immunity against porcine deltacoronavirus challenge in piglets

Authors: Jizong Li, Shuqing Zhao, Baotai Zhang, Jin Huang, Qi Peng, Li Xiao, Xuesong Yuan, Rongli Guo, Jinzhu Zhou, Baochao Fan, Tao Xue, Xuejiao Zhu, Chuanmin Liu, Xing Zhu, Lili Ren, Bin Li

Journal: J Virol

PubMed ID: 37846983

Doi: 10.1128/jvi.00958-23

Products & Services: Protein and Antibody Isolation

Structure-function relationships in ShKT domain peptides: ShKT-Ts1 from the sea anemone Telmatactis stephensoni

Authors: Karoline Sanches, Lauren M Ashwood, Abisola Ave-Maria Olushola-Siedoks, Dorothy C C Wai, Arfatur Rahman, Kashmala Shakeel, Muhammad Umair Naseem, Gyorgy Panyi, Peter J Prentis, Raymond S Norton

Journal: Proteins

PubMed ID: 37794633

Doi: 10.1002/prot.26594

Products & Services: Molecular Biology Reagents

Cell-Permeable Stimuli-Responsive Ubiquitin Probe for Time- Resolved Monitoring of Substrate Ubiquitination in Live Cells

Authors: Lu-Jun Liang, Yu Wang, Xiao Hua, Rujing Yuan, Qiong Xia, Rongtian Wang, Chuntong Li, Guo-Chao Chu, Lei Liu, and Yi-Ming Li

Journal: JACS Au

Doi: 10.1021/jacsau.3c00421

Products & Services: Gene Synthesis

A thermostable type I-B CRISPR-Cas system for orthogonal and multiplexed genetic engineering

Authors: Zhiheng Yang , Zilong Li , Bixiao Li , Ruihong Bu , Gao-Yi Tan , Zhengduo Wang , Hao Yan , Zhenguo Xin , Guojian Zhang , Ming Li , Hua Xiang, Lixin Zhang , Weishan Wang

Journal: Nat Commun .

PubMed ID: 37794017

Doi: 10.1038/s41467-023-41973-5

Products & Services: Custom DNA/RNA Oligos CRISPR Libraries

A 3D-printed blood-brain barrier model with tunable topology and cell-matrix interactions

Authors: Louis S Paone , Mohammed Mehdi Benmassaoud , Aidan Curran , Sebastián L Vega , Peter A Galie

Journal: Biofabrication .

PubMed ID: 37820611

Doi: 10.1088/1758-5090/ad0260

Products & Services: Peptide Synthesis

Sustained pigmentation causes DNA damage and invokes translesion polymerase Polκ for repair in melanocytes

Authors: Madeeha Ghazi, Shivangi Khanna, Yogaspoorthi Subramaniam, Jeyashri Rengaraju, Farina Sultan, Iti Gupta, Kanupriya Sharma, Sudhir Chandna, Rajesh S Gokhale, Vivek T Natarajan

Journal: Nucleic Acids Res

PubMed ID: 37697436

Doi: 10.1093/nar/gkad704

Products & Services: Polyclonal Antibody Services

A genetic screen identifies BEND3 as a regulator of bivalent gene expression and global DNA methylation

Authors: Lounis Yakhou, Anaelle Azogui, Nikhil Gupta, Julien Richard Albert, Fumihito Miura, Laure Ferry, Kosuke Yamaguchi, Sarah Battault, Pierre Therizols, Frédéric Bonhomme, Elouan Bethuel, Arpita Sarkar, Maxim V C Greenberg, Paola B Arimondo, Gael Cristofari, Olivier Kirsh, Takashi Ito, Pierre-Antoine Defossez

Journal: Nucleic Acids Res

PubMed ID: 37650637

Doi: 10.1093/nar/gkad719

Products & Services: Custom DNA/RNA Oligos

Disruption of sugar nucleotide clearance is a therapeutic vulnerability of cancer cells

Authors: Mihir B Doshi, Namgyu Lee, Tenzin Tseyang, Olga Ponomarova, Hira Lal Goel, Meghan Spears, Rui Li, Lihua Julie Zhu, Christopher Ashwood, Karl Simin, Cholsoon Jang, Arthur M Mercurio, Albertha J M Walhout, Jessica B Spinelli, Dohoon Kim

Journal: Nature

PubMed ID: 37880368

Doi: 10.1038/s41586-023-06676-3

Products & Services: Custom Vector Construction

A novel nanobody-based HER2-targeting antibody exhibits potent synergistic antitumor efficacy in trastuzumab-resistant cancer cells

Authors: Xinlin Liu, Linli Luan, Xi Liu, Dingwen Jiang, Junwen Deng, Jiazhen Xu, Yang Yuan, Jiyao Xing, Bingguan Chen, Dongming Xing, Haiming Huang

Journal: Front Immunol

PubMed ID: 37954614

Doi: 10.3389/fimmu.2023.1292839

Products & Services: Monoclonal Antibody Services