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A computationally designed antigen eliciting broad humoral responses against SARS-CoV-2 and related sarbecoviruses

Authors: Sneha Vishwanath, George William Carnell, Matteo Ferrari, Benedikt Asbach, Martina Billmeier, Charlotte George, Maria Suau Sans, Angalee Nadesalingam, Chloe Qingzhou Huang, Minna Paloniemi, Hazel Stewart, Andrew Chan, David Arthur Wells, Patrick Neckermann, David Peterhoff, Sebastian Einhauser, Diego Cantoni, Martin Mayora Neto, Ingo Jordan, Volker Sandig, Paul Tonks, Nigel Temperton, Simon Frost, Katharina Sohr, Maria Teresa Lluesma Ballesteros, Farzad Arbabi, Johannes Geiger, Christian Dohmen, Christian Plank, Rebecca Kinsley, Ralf Wagner, Jonathan Luke Heeney

Journal: Nat Biomed Eng

PubMed ID: 37749309

Doi: 10.1038/s41551-023-01094-2

Products & Services: Protein and Antibody Isolation

Deep mutational scanning and machine learning uncover antimicrobial peptide features driving membrane selectivity

Authors: Justin R. Randall; Luiz C. Vieira; Claus O. Wilke; Bryan W. Davies

Journal: biorxiv

PubMed ID: 37547010

Doi: 10.1101/2023.07.28.551017

Products & Services: Peptide Synthesis

The cryo-EM-delineated mechanism underlying mimicry of CXCR4 agonism enables widespread stem cell neuroprotection in a mouse model of ALS

Authors: Xiaohong Sang; Haizhan Jiao; Qian Meng; Xiong Fang; Kartik S. Sundaram; Jiao Zhou; Yan Xu; Asuka I. W. Alvarado; Ruslan L. Nuryyev; Jitka Ourenik; Vaclav Ourednik; Iris S. Huang; Xiang Liu; Yuheng Mei; Tingli Qian; Aaron Ciechanover; Donald P. Pizzo; Michael A. Lane; Lyandysha V. Zholudeva; Jing An; Evan Y. Snyder; Hongli Hu; Ziwei Huang

Journal: biorxiv

PubMed ID: 40672153

Doi: 10.1101/2025.07.08.663251

Products & Services: Protein and Antibody Isolation

Coordinated regulation by lncRNAs results in tight lncRNA-target couplings

Authors: Hua-Sheng Chiu; Sonal Somvanshi; Chung-Te Chang; Eric James de Bony de Lavergne; Zhaowen Wei; Chih-Hung Hsieh; Wim Trypsteen; Kathleen A. Scorsone; Ektaben Patel; Tien T. Tang; David B. Flint; Mohammad Javad Najaf Panah; Hyunjae Ryan Kim; Purva Rathi; Yan-Hwa Wu Lee; Sarah E. Woodfield; Sanjeev A. Vasudevan; Andras Attila Heczey; M. Waleed Gaber; Gabriel O. Sawakuchi; Ting-Wen Chen; Pieter Mestdagh; Xuerui Yang; Pavel Sumazin

Journal: Cell Genomics

PubMed ID: 40628267

Doi: 10.1016/j.xgen.2025.100927

Coordinated regulation by lncRNAs results in tight lncRNA-target couplings

Journal: Cell Genomics

PubMed ID: 40628267

Doi: 10.1016/j.xgen.2025.100927

Novel In Silico mRNA vaccine design exploiting proteins of M. tuberculosis that modulates host immune responses by inducing epigenetic modifications

Authors: H. Al Tbeishat

Journal: Scientific REPORTS

PubMed ID: 35301360

Doi: 10.1038/s41598-022-08506-4

Products & Services: Codon Optimization

CRISPR-ChIP reveals selective regulation of H3K79me2 by Menin in MLL leukemia

Authors: Omer Gilan, Laure Talarmain, Charles C Bell, Daniel Neville, Kathy Knezevic, Daniel T Ferguson, Marion Boudes, Yih-Chih Chan, Chen Davidovich, Enid Y N Lam, Mark A Dawson

Journal: Nat Struct Mol Biol

PubMed ID: 37679565

Doi: 10.1038/s41594-023-01087-4

Products & Services: Protein and Antibody Isolation

Differential regulatory control of curli (csg) gene expression in Salmonella enterica serovar Typhi requires more than a functional CsgD regulator

Authors: Camille Ou, Charles M Dozois, France Daigle

Journal: Sci Rep

PubMed ID: 37689734

Doi: 10.1038/s41598-023-42027-y

Products & Services: Monoclonal Antibody Services

Exploiting the aggregation propensity of beta-lactamases to design inhibitors that induce enzyme misfolding

Authors: Ladan Khodaparast, Laleh Khodaparast, Guiqin Wu, Emiel Michiels, Rodrigo Gallardo, Bert Houben, Teresa Garcia, Matthias De Vleeschouwer, Meine Ramakers, Hannah Wilkinson, Ramon Duran-Romaña, Johan Van Eldere, Frederic Rousseau, Joost Schymkowitz

Journal: Nat Commun

PubMed ID: 37689716

Doi: 10.1038/s41467-023-41191-z

Products & Services: Peptide Synthesis

Development of a plant-based oral vaccine candidate against the bovine respiratory pathogen

Authors: Angelo Kaldis, Muhammed Salah Uddin, Jose Ortiz Guluarte, Coby Martin, Trevor W Alexander, Rima Menassa

Journal: Front Plant Sci

PubMed ID: 37790785

Doi: 10.3389/fpls.2023.1251046

Products & Services: Recombinant Antibody Expression