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Selective CK1α degraders exert antiproliferative activity against a broad range of human cancer cell lines

Authors: Gisele Nishiguchi , Lauren G Mascibroda , Sarah M Young , Elizabeth A Caine , Sherif Abdelhamed , Jeffrey J Kooijman , Darcie J Miller , Sourav Das , Kevin McGowan , Anand Mayasundari , Zhe Shi , Juan M Barajas , Ryan Hiltenbrand , Anup Aggarwal , Yunchao Chang , Vibhor Mishra , Shilpa Narina , Melvin Thomas , Allister J Loughran , Ravi Kalathur , Kaiwen Yu , Suiping Zhou , Xusheng Wang , Anthony A High , Junmin Peng , Shondra M Pruett-Miller , Danette L Daniels , Marjeta Urh , Anang A Shelat , Charles G Mullighan , Kristin M Riching , Guido J R Zaman , Marcus Fischer , Jeffery M Klco , Zoran Rankovic

Journal: Nat Commun

PubMed ID: 38228616

Doi: 10.1038/s41467-024-44698-1

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PIEZO1 loss-of-function compound heterozygous mutations in the rare congenital human disorder Prune Belly Syndrome

Authors: Nathalia G Amado , Elena D Nosyreva , David Thompson , Thomas J Egeland , Osita W Ogujiofor , Michelle Yang , Alexandria N Fusco , Niccolo Passoni , Jeremy Mathews , Brandi Cantarel , Linda A Baker , Ruhma Syeda

Journal: Nat Commun

PubMed ID: 38184690

Doi: 10.1038/s41467-023-44594-0

Products & Services: PCR Cloning and Subcloning

A stapled lipopeptide platform for preventing and treating highly pathogenic viruses of pandemic potential

Authors: Gregory H Bird , J J Patten , William Zavadoski , Nicole Barucci , Marina Godes , Benjamin M Moyer , Callum D Owen , Paul DaSilva-Jardine , Donna S Neuberg , Richard A Bowen , Robert A Davey , Loren D Walensky

Journal: Nat Commun

PubMed ID: 38177138

Doi: 10.1038/s41467-023-44361-1

Products & Services: Plasmid DNA Preparation

Massively parallel profiling of RNA-targeting CRISPR-Cas13d

Authors: Hung-Che Kuo , Joshua Prupes , Chia-Wei Chou , Ilya J Finkelstein

Journal: Nat Commun

PubMed ID: 37034598

Doi: 10.1101/2023.03.27.534188

Products & Services: Custom Vector Construction

Correlations of receptor desensitization of gain-of-function GABRB3 variants with clinical severity

Authors: Susan X N Lin, Philip K Ahring, Angelo Keramidas, Vivian W Y Liao, Rikke S Møller, Mary Chebib, Nathan L Absalom

Journal: Brain

PubMed ID: 37647766

Doi: 10.1093/brain/awad285

Products & Services: Plasmid DNA Preparation

Let-7a-5p Regulates Animal Lipid Accumulation by Targeting Srebf2 and Thbs1 Signaling

Authors: Jiahao Shao , Genglong Jiang , Yanhong Li, Meigui Wang, Tao Tang, Jie Wang , Xianbo Jia and Songjia Lai

Journal: Int. J. Mol. Sci

Doi: 10.3390/ijms25020894

Products & Services: Protein Electrophoresis and Western

Biosynthesis of 10-Hydroxy-2-decenoic Acid through a One-Step Whole-Cell Catalysis

Authors: Ke Fang , Ziting Xu , Lu Yang , Quan Cui , Bowen Du , Huijing Liu , Ruiming Wang , Piwu Li , Jing Su , Junqing Wang

Journal: J Agric Food Chem .

PubMed ID: 38175798

Doi: 10.1021/acs.jafc.3c08142

Products & Services: Gene Synthesis

Guiding bar motif of thioredoxin reductase 1 modulates enzymatic activity and inhibitor binding by communicating with the co-factor FAD and regulating the flexible C-terminal redox motif

Authors: Wuyang Shi , Shibo Sun , Haowen Liu , Yao Meng , Kangshuai Ren , Guoying Wang , Minghui Liu , Jiaqi Wu , Yue Zhang , Huang Huang , Meiyun Shi , Weiping Xu , Qiang Ma , Bingbing Sun , Jianqiang Xu

Journal: Redox biology

Doi: 10.1016/j.redox.2024.103050

Products & Services: Protein and Antibody Isolation

N-acetyltransferase 10 regulates alphavirus replication via N4- acetylcytidine (ac4C) modification of the lymphocyte antigen six family member E (LY6E) mRNA

Authors: Yamei Dang , Jia Li , Yuchang Li , Yuan Wang , Yajing Zhao , Ningbo Zhao , Wanying Li , Hui Zhang , Chuantao Ye , Hongwei Ma , Liang Zhang , He Liu , Yangchao Dong , Min Yao , Yingfeng Lei , Zhikai Xu , Fanglin Zhang , Wei Ye

Journal: J Virol .

PubMed ID: 38169284

Doi: 10.1128/jvi.01350-23

Products & Services: Polyclonal Antibody Services

Redox signalling regulates breast cancer metastasis via phenotypic and metabolic reprogramming due to p63 activation by HIF1α

Authors: Zuen Ren, Malindrie Dharmaratne, Huizhi Liang, Outhiriaradjou Benard, Miriam Morales-Gallego, Kimita Suyama, Viney Kumar, Atefeh Taherian Fard, Ameya S Kulkarni, Michael Prystowsky, Jessica C Mar, Larry Norton, Rachel B Hazan

Journal: Br J Cancer

PubMed ID: 38238426

Doi: 10.1038/s41416-023-02522-5

Products & Services: ORF cDNA Clones/MolecularCloud