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Generation of host-directed and virus-specific antivirals using targeted protein degradation promoted by small molecules and viral RNA mimics

Authors: Nan Zhao, Jessica Sook Yuin Ho, Fanye Meng, Simin Zheng, Andrew P Kurland, Lu Tian, Martha Rea-Moreno, Xiangyang Song, Ji-Seon Seo, H Ümit Kaniskan, Aartjan J W Te Velthuis, Domenico Tortorella, Ya-Wen Chen, Jeffrey R Johnson, Jian Jin, Ivan Marazzi

Journal: Cell Host Microbe

PubMed ID: 37339625

Doi: 10.1016/j.chom.2023.05.030

Products & Services: Protein Electrophoresis and Western

Plasmodium GPI-anchored micronemal antigen is essential for parasite transmission through the mosquito host

Authors: Charlie Jennison, Janna M Armstrong, Dorender A Dankwa, Nina Hertoghs, Sudhir Kumar, Biley A Abatiyow, Myo Naung, Nana K Minkah, Kristian E Swearingen, Robert Moritz, Alyssa E Barry, Stefan H I Kappe, Ashley M Vaughan

Journal: Mol Microbiol

PubMed ID: 37314965

Doi: 10.1111/mmi.15078

Products & Services: Molecular Biology Reagents

Optogenetic inhibition of Gα signalling alters and regulates circuit functionality and early circuit formation

Authors: Jayde Lockyer, Andrew Reading, Silvia Vicenzi, Caroline Delandre, Owen Marshall, Robert Gasperini, Lisa Foa, John Y Lin

Journal: biorxiv

PubMed ID: 37214843

Doi: 10.1101/2023.05.06.539674

Products & Services: Protein and Antibody Isolation

Leptospiral imelysin (LIC_10713) is secretory, immunogenic and binds to laminin, fibronectin, and collagen IV

Authors: Abhijit Sarma, Dhandapani Gunasekaran, Homen Phukan, Akhil Baby, Suneetha Hariharan, Arun Kumar De, Debasis Bhattacharya, Sankar Natesan, Jebasingh Tennyson, Madathiparambil Gopalakrishnan Madanan

Journal: Appl Microbiol Biotechnol

PubMed ID: 37227474

Doi: 10.1007/s00253-023-12573-6

Products & Services: Molecular Biology Reagents

CDK12 and Integrator-PP2A complex modulates LEO1 phosphorylation for processive transcription elongation

Authors: Min Qiu, Zhinang Yin, Honghong Wang, Lingyu Lei, Conghui Li, Yali Cui, Rong Dai, Peiyuan Yang, Ying Xiang, Qiuzi Li, Junhui Lv, Zhuang Hu, Min Chen, Hai-Bing Zhou, Pingping Fang, Ruijing Xiao, Kaiwei Liang

Journal: Sci Adv

PubMed ID: 37205756

Doi: 10.1126/sciadv.adf8698

Products & Services: Molecular Biology Reagents

Analysis and comparisons of gene expression changes in patient- derived neurons from ROHHAD, CCHS, and PWS

Authors: A Kaitlyn Victor, Tayler Hedgecock, Martin Donaldson, Daniel Johnson, Casey M Rand, Debra E Weese-Mayer, Lawrence T Reiter

Journal: Front Pediatr

PubMed ID: 37234859

Doi: 10.3389/fped.2023.1090084

Products & Services: Molecular Biology Reagents

Antibacterial mechanism of the novel antimicrobial peptide Jelleine-Ic and its efficacy in controlling Pseudomonas syringae pv actinidiae in kiwifruit

Authors: Mingyu Zhang, Lifang Wang, Wei Tang, Yue Xing, Pu Liu, Xiangli Dang

Journal: Pest Manag Sci

PubMed ID: 37184207

Doi: 10.1002/ps.7548

Products & Services: Molecular Biology Reagents

Strong immune responses and protection of PcrV and OprF-I mRNA vaccine candidates against Pseudomonas aeruginosa

Authors: Xingyun Wang, Cong Liu, Nino Rcheulishvili, Dimitri Papukashvili, Fengfei Xie, Jiao Zhao, Xing Hu, Kaiwei Yu, Nuo Yang, Xuehua Pan, Xueyan Liu, Peng George Wang, Yunjiao He

Journal: npj Vaccines

PubMed ID: 37231060

Doi: 10.1038/s41541-023-00672-4

Products & Services: Polyclonal Antibody Services

Inositol pyrophosphates activate the vacuolar transport chaperone complex in yeast by disrupting a homotypic SPX domain interaction

Authors: Joka Pipercevic, Bastian Kohl, Ruta Gerasimaite, Véronique Comte-Miserez, Sarah Hostachy, Thomas Müntener, Elia Agustoni, Henning Jacob Jessen, Dorothea Fiedler, Andreas Mayer, Sebastian Hiller

Journal: Nat Commun

PubMed ID: 37156835

Doi: 10.1038/s41467-023-38315-w

Products & Services: Molecular Biology Reagents

In-cell kinetic stability is an essential trait in metallo-β-lactamase evolution

Authors: Lisandro J González, Guillermo Bahr, Mariano M González, Robert A Bonomo, Alejandro J Vila

Journal: Nat Chem Biol

PubMed ID: 37188957

Doi: 10.1038/s41589-023-01319-0

Products & Services: Gene Synthesis