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Dissecting a two-domain alginate lyase of family PL6 reveals a mechanistic basis for substrate specificity and enzyme activity

Authors: Mikkel Madsen; Mette E. R nne; Agnes B. Petersen; Tobias Tandrup; Bo Pilgaard; Jesper Holck; Finn L. Aachmann; Casper Wilkens; Leesa J. Klau; Birte Svensson

Journal: The Journal of Biological Chemistry

PubMed ID: 41638429

Doi: 10.1016/j.jbc.2026.111227

Bile salt hydrolase catalyses formation of amine-conjugated bile acids

Authors: Bipin Rimal, Stephanie L Collins, Ceylan E Tanes, Edson R Rocha, Megan A Granda, Sumeet Solanki, Nushrat J Hoque, Emily C Gentry, Imhoi Koo, Erin R Reilly, Fuhua Hao, Devendra Paudel, Vishal Singh 11, Tingting Yan 12, Min Soo Kim 2, Kyle Bittinger 3, Joseph P Zackular 13 14, Kristopher W Krausz 12, Dhimant Desai 15, Shantu Amin 15, James P Coleman 4, Yatrik M Shah 5, Jordan E Bisanz 2 16, Frank J Gonzalez 12, John P Vanden Heuvel 1 17, Gary D Wu 18, Babette S Zemel 3, Pieter C Dorrestein 7 8, Emily E Weinert 2 6, Andrew D Patterson 19 20 21

Journal: Nature

PubMed ID: 38326609

Doi: 10.1038/s41586-023-06990-w

Products & Services: Gene Synthesis

Harnessing eukaryotic retroelement proteins for transgene insertion into human safe-harbor loci

Authors: Xiaozhu Zhang, Briana Van Treeck, Connor A. Horton, Jeremy J. R. McIntyre, Sarah M. Palm, Justin L. Shumate & Kathleen Collins

Journal: Nat Biotechnol

PubMed ID: 38379101

Doi: 10.1038/s41587-024-02137-y

Products & Services: Plasmid DNA Preparation

Disordered regions mediate the interaction of p53 and MRE11

Authors: Sinem Usluer , Markus Galhuber , Yukti Khanna , Benjamin Bourgeois , Emil Spreitzer , Helene Michenthaler, Andreas Prokesch, Tobias Madl

Journal: Cell Research

PubMed ID: 38123020

Doi: 10.1016/j.bbamcr.2023.119654

Products & Services: Custom Vector Construction

Biomimetic bacteria-derived nanoclusters enhance ferroptosis cancer immunotherapy through synergistic CRISPR-photothermo modulation

Authors: Xiuhua Pan , Jie Yang , Ruixin Kang , Jun Zhang , Zongwei Hu , Ning Yang , Zengyi Liu , Zengguang Jia , Xiawei Zhou , Qi Shen

Journal: Nano Today

Doi: 10.1016/j.nantod.2024.102213

Products & Services: CRISPR Services

An Antioxidative and Active Shrinkage Hydrogel Integratedly Promotes Re-Epithelization and Skin Constriction for Enhancing Wound Closure

Authors: Jiacheng Sun, Wang Jia, Hedong Qi, Jiawei Huo, Xiaodan Liao, Yuan Xu, Jun Wang, Zihao Sun, Yang Liu, Jingchao Liu, Mingming Zhen, Chunru Wang, Chunli Bai

Journal: Adv Mater

PubMed ID: 38332741

Doi: 10.1002/adma.202312440

Products & Services: Protein and Antibody Isolation

Immune evasion, infectivity, and fusogenicity of SARS-CoV-2 BA. 2.86 and FLip variants

Authors: Panke Qu 1, Kai Xu 1, Julia N Faraone 2, Negin Goodarzi 1, Yi-Min Zheng 1, Claire Carlin 3, Joseph S Bednash 4, Jeffrey C Horowitz 4, Rama K Mallampalli 4, Linda J Saif 5, Eugene M Oltz 6, Daniel Jones 7, Richard J Gumina 8, Shan-Lu Liu

Journal: Cell

PubMed ID: 38194968

Doi: 10.1016/j.cell.2023.12.026

Products & Services: PCR Cloning and Subcloning

A Cancer Nanovaccine for Co-Delivery of Peptide Neoantigens and Optimized Combinations of STING and TLR4 Agonists

Authors: Jessalyn J. Baljon, Alexander J. Kwiatkowski, Hayden M. Pagendarm, Payton T. Stone, Amrendra Kumar, Vijaya Bharti, Jacob A. Schulman, Kyle W. Becker, Eric W. Roth, Plamen P. Christov, Sebastian Joyce, and John T. Wilson*

Journal: ACS Nano

PubMed ID: 38386282

Doi: 10.1021/acsnano.3c04471

Products & Services: Peptide Synthesis

A Gamma-adapted subunit vaccine induces broadly neutralizing antibodies against SARS-CoV-2 variants and protects mice from infection

Authors: Lorena M Coria , Juan Manuel Rodriguez , Agostina Demaria , Laura A Bruno , Mayra Rios Medrano , Celeste Pueblas Castro , Eliana F Castro , Sabrina A Del Priore , Andres C Hernando Insua , Ingrid G Kaufmann , Lucas M Saposnik , William B Stone , Lineia Prado , Ulises S Notaro , Ayelen N Amweg , Pablo U Diaz , Martin Avaro , Hugo Ortega , Ana Ceballos , Valeria Krum , Francisco M Zurvarra , Johanna E Sidabra , Ignacio Drehe , Jonathan A Baqué , Mariana Li Causi , Analia V De Nichilo , Cristian J Payes , Teresa Southard , Julio C Vega , Albert J Auguste , Diego E Álvarez , Juan M Flo , Karina A Pasquevich , Juliana Cassataro

Journal: Nat Commun

PubMed ID: 38307851

Doi: 10.1038/s41467-024-45180-8

Products & Services: Codon Optimization

The chromatin-associated lncREST ensures effective replication stress response by promoting the assembly of fork signaling factors

Authors: Luisa Statello , José Miguel Fernandez-Justel , Jovanna González , Marta Montes , Alessia Ranieri , Enrique Goñi , Aina M Mas , Maite Huarte

Journal: Nat Commun

PubMed ID: 38302450

Doi: 10.1038/s41467-024-45183-5

Products & Services: Custom Vector Construction