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Structural basis of regulated N-glycosylation at the secretory translocon

Authors: Melvin Yamsek, Mengxiao Ma, Roshan Jha, Yu Wan, Qianru Li, Frank Zhong, Katherine DeLong, Zhe Ji, Rajat Rohatgi, Robert J Keenan

Journal: Nature

PubMed ID: 41261126

Doi: 10.1038/s41586-025-09756-8.

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Anti-PD-L2 immunotherapy is efficacious against melanoma in aged hosts through IL-17 and IFNγ signalling

Authors: Carlos O Ontiveros, Myrna G Garcia, Clare E Murray, Yilun Deng, Haiyan Bai, Christopher Tanner, Bernice Leung, Xin Li, Alvaro Padron, Ryan M Reyes, Aravind Kancharla, Kah Teong Soh, Shanmugarajan Krishnan, Dhan Chand, Akshaya Balasubramanian, Courtney Hegner, Claudia V Jakubzick, Harshita B Gupta, Mary Jo Turk, Mark Sundrud, Jose R Conejo-Garcia, Tyler J Curiel

Journal: Nature Communications

PubMed ID: 41261166

Doi: 10.1038/s41467-025-65025-2.

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Preclinical assessment of two FcγRI-specific antibodies that competitively inhibit immune complex-FcγRI binding to suppress autoimmune responses

Authors: Tosca Holtrop, Arianne M Brandsma, Louris J Feitsma, Steffen Krohn, Petra Moerer, Frederique van den Haak, Anouk Versnel, Leonie Voss, Elsemieke M Passchier, Maaike Nederend, J H Marco Jansen, Anouk G van Mourik, Rolf T Urbanus, Diane van der Woude, Roger E G Schutgens, Rene E M Toes, Bert J C Janssen, Anja Lux, Kevin Budding, Matthias Peipp, Jeanette H W Leusen

Journal: Nature Communications

PubMed ID: 41258113

Doi: 10.1038/s41467-025-65133-z.

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ER protein CLCC1 promotes nuclear envelope fusion in herpesviral and host processes

Authors: Bing Dai, Adrian W Sperl, Lucas Polack, Isabel Mejia, Haley Dame, Tien Huynh, Chloe Deveney, Nathalie Lavoie, Chanyoung Lee, John G Doench, Matthew D Daugherty, Ekaterina E Heldwein

Journal: Nature Communications

PubMed ID: 41271665

Doi: 10.1038/s41467-025-65115-1.

Latent-TGF-β has a domain swapped architecture

Authors: Mingliang Jin, Robert I Seed, Tiffany Shing, Li Wang, Junrui Li, Yifan Cheng, Stephen L Nishimura

Journal: Nature Communications

PubMed ID: 41290649

Doi: 10.1038/s41467-025-65465-w.

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Structural insight into bicarbonate-mediated carboxylation by human vitamin K-dependent carboxylase

Authors: Ke Wu, Zheng Wang, Deqiang Yao, Shaobai Li, Xiaozhu Wang, Yuanyuan Zhang, Mi Cao, Yafeng Shen, Shunpeng Xing, Jian Wu, Ming Lei, Pengfei Lan

Journal: Nature Communications

PubMed ID: 41290650

Doi: 10.1038/s41467-025-65488-3.

Products & Services: Protein and Antibody Isolation

Development of a cross-protective common cold coronavirus vaccine

Authors: Tanushree Dangi, Shiyi Li, Pablo Penaloza-MacMaster

Journal: Journal of Virology

PubMed ID: 41123344

Doi: 10.1128/jvi.01526-25

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PCR-generated DNA templates enable efficient, rapid, and cost-effective mRNA synthesis

Authors: Naveen Kumar, Nicholas C Hazell, Jiani Bei, Tina Nguyen, Haitao Hu

Journal: Methods

PubMed ID: 40825451

Doi: 10.1016/j.ymeth.2025.08.007

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GSH-activable and cytolytic iPep-coupled immune nanoagonist for cancer synergetic therapy

Authors: Shuangshuang Ji, Xiangxiang Xu, Ang Li, Hanjie Liu, Jiang Zhu, Hao Fei

Journal: Biomaterials

PubMed ID: 40373515

Doi: 10.1016/j.biomaterials.2025.123402

Products & Services: Peptide Synthesis

De novo designed voltage-gated anion channels suppress neuron firing

Authors: Chen Zhou, Huican Li, Jiaxing Wang, Cheng Qian, Hui Xiong, Zhilin Chu, Qiming Shao, Xuan Li, Shijin Sun, Ke Sun, Aiqin Zhu, Jiawei Wang, Xueqin Jin, Fan Yang, Tamer M Gamal El-Din, Bo Li, Jing Huang, Kun Wu, Peilong Lu

Journal: Cell

PubMed ID: 41106381

Doi: 10.1016/j.cell.2025.09.023

Products & Services: Protein and Antibody Isolation