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Generation of antigen-specific paired-chain antibodies using large language models

Authors: Perry T Wasdin, Nicole V Johnson, Alexis K Janke, Sofia Held, Toma M Marinov, Gwen Jordaan, Rebecca A Gillespie, Léna Vandenabeele, Fani Pantouli, Olivia C Powers, Matthew J Vukovich, Clinton M Holt, Jeongryeol Kim, Grant Hansman, Jennifer Logue, Helen Y Chu, Sarah F Andrews, Masaru Kanekiyo, Giuseppe A Sautto, Ted M Ross, Daniel J Sheward, Jason S McLellan, Alexandra A Abu-Shmais, Ivelin S Georgiev

Journal: Cell

PubMed ID: 41192421

Doi: 10.1016/j.cell.2025.10.006.

Products & Services: Protein and Antibody Isolation

On-target off-tumor toxicity of claudin18.2-directed CAR-T cells in preclinical models

Authors: Filippo Birocchi, Antonio J Almazan, Aiyana Parker, Amanda A Bouffard, Sadie Goncalves, Christopher Kelly, Jessica Frank, Mark B Leick, Nicholas J Haradhvala, Shaw Kagawa, Gad Getz, Giulia Escobar, Diego Salas-Benito, Adele Mucci, Trisha R Berger, Marcela V Maus

Journal: Nature Communications

PubMed ID: 41176533

Doi: 10.1038/s41467-025-61858-z.

Products & Services: Monoclonal Antibody Services

Nivolumab plus ipilimumab induce hyper-progression in renal medullary carcinoma: results of a phase II trial and preclinical evidence

Authors: Melinda Soeung, Xinmiao Yan, Ciro Zanca, Jing Qian, Menuka Karki, Fei Duan, Hania Khan, Li Zhang, David H Peng, Mariah Williams, Rong He, Ziheng Chen, Luigi Perelli, Jianfeng Chen, Rebecca S Tidwell, Pankaj K Chauhan, Courtney N Le, Truong N A Lam, Nirjar Bhattacharya, Rutvi Shah, I-Lin Ho, Jason P Gay, Caroline C Carrillo, Ningping Feng, Kang Le, Guang Gao, Teresa L Perry, Faika Mseeh, Yongying Jiang, Quanyun A Xu, Niki Marie Zacharias, Rahul A Sheth, Tharakeswara K Bathala, Priya Rao, Najat C Daw, Durga N Tripathi, Cheryl L Walker, Mohammad M Mohammad, Jianhua Zhang, Guangchun Han, Yanshuo Chu, Ruiping Wang, Minghao Dang, Enyu Dai, Fuduan Peng, Yunhe Liu, Akshaya Jadhav, Wenhua Lang, Claudio A Arrechedera, Leticia Campos Clemente, Edwin R Parra, Hsinyi Lu, Cara L Haymaker, Ignacio I Wistuba, Andrew Futreal, Andrea Viale, Michael J Soth, Philip Jones, Joseph R Marszalek, Timothy Heffernan, Giulio F Draetta, Nizar M Tannir, Jianjun Gao, Linghua Wang, Giannicola Genovese, Pavlos Msaouel

Journal: Nature Communications

PubMed ID: 41290625

Doi: 10.1038/s41467-025-65462-z.

Products & Services: Molecular Biology Tools

Cancer-associated snaR-A noncoding RNA interacts with core splicing machinery and disrupts processing of mRNA subpopulations

Authors: Sihang Zhou, Simon Lizarazo, Sandip Chorghade, Leela Mouli, Ruiying Cheng, Rajendra K C, Auinash Kalsotra, Kevin Van Bortle

Journal: Nature Communications

PubMed ID: 41290606

Doi: 10.1038/s41467-025-65448-x.

Products & Services: Molecular Biology Reagents

Glycosaminoglycans activate peptidylarginine deiminase 4 by enhancing calcium affinity

Authors: Grzegorz P. Bereta， Ewa Bielecka， Karolina Marzec， Łukasz Pijanowski， Artur P. Biela， Piotr Wilk， Marta Kamińska， Jakub Nowak， Elżbieta Wątor-Wilk， Przemysław Grudnik， Dominik Kowalczyk， Joanna Kozieł， Piotr Mydel， Marcin Poręba， Tomasz Kantyka

Journal: Proceedings of the National Academy of Sciences of the United States of America

PubMed ID: 41166417

Doi: doi.org/10.1073/pnas.2508369122

Products & Services: Gene Synthesis

SmallTalk: a novel small-sized fusion tag for peptide expression and purification

Authors: Atika Tariq, Nestor G Casillas-Vega, Alma Gomez-Loredo, Xristo Zarate

Journal: FEBS Open Bio

PubMed ID: 41220226

Doi: 10.1002/2211-5463.70147

Products & Services: Gene Synthesis

Structural insights into antagonist recognition by the vasopressin V2 receptor

Authors: Tianwei Zhang, Hongli Liu, Chongzhao You, Yixiao Zhang, Youwei Xu, Benxun Pan, Canrong Wu, Sanshan Jin, Yu-Ling Yin, Kai Wu, Yue Chen, Hong Sun, Yuan Si, Yangxia Tan, Wanchao Yin, H Eric Xu, Dong Guo, Yi Jiang

Journal: Nature Communications

PubMed ID: 41188237

Doi: 10.1038/s41467-025-64735-x

Products & Services: Protein and Antibody Isolation

Crystal structures of Ryanodine Receptor reveal dantrolene and azumolene interactions guiding inhibitor development

Authors: Hadiatullah Hadiatullah, Lianyun Lin, Zhiyan Wang, Rajamanikandan Sundarraj, Qing Wang, Xinru Lai, Nagomi Kurebayashi, Takuya Kobayashi, Toshiko Yamazawa, Yu Seby Chen, Wenlan Wang, Hongxia Zhao, Yiqing Yin, Takashi Murayama, Filip Van Petegem, Zhiguang Yuchi

Journal: Nature Communications

PubMed ID: 41253812

Doi: 10.1038/s41467-025-65096-1.

Products & Services: Protein and Antibody Isolation

Anti-PD-L2 immunotherapy is efficacious against melanoma in aged hosts through IL-17 and IFNγ signalling

Authors: Carlos O Ontiveros, Myrna G Garcia, Clare E Murray, Yilun Deng, Haiyan Bai, Christopher Tanner, Bernice Leung, Xin Li, Alvaro Padron, Ryan M Reyes, Aravind Kancharla, Kah Teong Soh, Shanmugarajan Krishnan, Dhan Chand, Akshaya Balasubramanian, Courtney Hegner, Claudia V Jakubzick, Harshita B Gupta, Mary Jo Turk, Mark Sundrud, Jose R Conejo-Garcia, Tyler J Curiel

Journal: Nature Communications

PubMed ID: 41261166

Doi: 10.1038/s41467-025-65025-2.

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Preclinical assessment of two FcγRI-specific antibodies that competitively inhibit immune complex-FcγRI binding to suppress autoimmune responses

Authors: Tosca Holtrop, Arianne M Brandsma, Louris J Feitsma, Steffen Krohn, Petra Moerer, Frederique van den Haak, Anouk Versnel, Leonie Voss, Elsemieke M Passchier, Maaike Nederend, J H Marco Jansen, Anouk G van Mourik, Rolf T Urbanus, Diane van der Woude, Roger E G Schutgens, Rene E M Toes, Bert J C Janssen, Anja Lux, Kevin Budding, Matthias Peipp, Jeanette H W Leusen

Journal: Nature Communications

PubMed ID: 41258113

Doi: 10.1038/s41467-025-65133-z.

Products & Services: Catalog Antibodies