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The intrinsic substrate specificity of the human tyrosine kinome

Authors: Tomer M. Yaron-Barir, Brian A. Joughin, Emily M. Huntsman, Alexander Kerelsky, Daniel M. Cizin, Benjamin M. Cohen, Amit Regev, Junho Song, Neil Vasan, Ting-Yu Lin, Jose M. Orozco, Christina Schoenherr, Cari Sagum, Mark T. Bedford, R. Max Wynn, Shih-Chia Tso, David T. Chuang, Lei Li, Shawn S.-C. Li, Pau Creixell, Konstantin Krismer, Mina Takegami, Harin Lee, Bin Zhang, Jingyi Lu, Ian Cossentino, Sean D. Landry, Mohamed Uduman, John Blenis, Olivier Elemento, Margaret C. Frame, Peter V. Hornbeck, Lewis C. Cantley, Benjamin E. Turk, Michael B. Yaffe & Jared L. Johnson

Journal: Nature

PubMed ID: 38720073

Doi: 10.1038/s41586-024-07407-y

Products & Services: Codon Optimization

Mycobacterial biotin synthases require an auxiliary protein to convert dethiobiotin into biotin

Authors: Di Qu, Peng Ge, Laure Botella, Sae Woong Park, Ha-Na Lee, Natalie Thornton, James M. Bean, Inna V. Krieger, James C. Sacchettini, Sabine Ehrt, Courtney C. Aldrich & Dirk Schnappinger

Journal: Nat Commun

PubMed ID: 38755122

Doi: 10.1038/s41467-024-48448-1.

Products & Services: Catalog Antibodies

Contemporary HIV-1 consensus Env with AI-assisted redesigned hypervariable loops promote antibody binding

Authors: Hongjun Bai, Eric Lewitus, Yifan Li, Paul V. Thomas, Michelle Zemil, Mélanie Merbah, Caroline E. Peterson, Thujitha Thuraisamy, Phyllis A. Rees, Agnes Hajduczki, Vincent Dussupt, Bonnie Slike, Letzibeth Mendez-Rivera, Annika Schmid, Erin Kavusak, Mekhala Rao, Gabriel Smith, Jessica Frey, Alicea Sims, Lindsay Wieczorek, Victoria Polonis, Shelly J. Krebs, Julie A. Ake, Sandhya Vasan, Diane L. Bolton, M. Gordon Joyce, Samantha Townsley & Morgane Rolland

Journal: Nat Commun

PubMed ID: 38724518

Doi: 10.1038/s41467-024-48139-x

Products & Services: Gene Synthesis

Structural basis for double-stranded RNA recognition by SID1

Authors: Runhao Wang, Ye Cong, Dandan Qian, Chuangye Yan, Deshun Gong

Journal: Nucleic Acids Res

PubMed ID: 38742627

Doi: 10.1093/nar/gkae395

Enhanced detection of ligand-PPARγ binding based on surface plasmon resonance through complexation with SRC1- or NCOR2-related polypeptide

Authors: Yiting Wang , Mingzhu Luo , Luyang Che , Qixin Wu , Jingzhe Li , Yanyan Ma , Jingyi Wang , Changzhen Liu

Journal: International Journal of Biological Macromolecules

PubMed ID: 38670200

Doi: 10.1016/j.ijbiomac.2024.131865

Products & Services: Gene Synthesis

A Tag-Free Platform for Synthesis and Screening of Cyclic Peptide Libraries

Authors: Angele Bruce , Victor Adebomi , Patrick Czabala , Jonathan Palmer , William M McFadden , Zachary C Lorson , Ryan L Slack , Gaurav Bhardwaj , Stefan G Sarafianos , Monika Raj

Journal: Angew Chem Int Ed Engl

PubMed ID: 38529717

Doi: 10.1002/anie.202320045

Products & Services: PCR Cloning and Subcloning

BRD9 regulates normal human hematopoietic stem cell function and lineage differentiation

Authors: Swati Garg, Wei Ni, Basudev Chowdhury, Ellen L Weisberg, Martin Sattler, James D Griffin

Journal: Cell Death Differ

PubMed ID: 38816579

Doi: 10.1038/s41418-024-01306-5

Products & Services: Molecular Biology Reagents

Filtered Saliva for Rapid and Accurate Analyte Detection for POC Diagnostics

Authors: Nadia Farsaeivahid, Christian Grenier, Ming L Wang

Journal: Diagnostics (Basel)

PubMed ID: 38893615

Doi: 10.3390/diagnostics14111088

Products & Services: Protein and Antibody Isolation

An Active and Versatile Electron Transport System for Cytochrome P450 Monooxygenases from the Alkane Degrading Organism Acinetobacter sp OC4

Authors: Fabian Peter Josef Schultes, Leon Welter, Doreen Hufnagel, Melanie Heghmanns, Müge Kasanmascheff, Carolin Muegge

Journal: Chembiochem

PubMed ID: 38787654

Doi: 10.1002/cbic.202400098

Products & Services: Molecular Biology Reagents

Insights into PCSK9-LDLR Regulation and Trafficking via the Differential Functions of MHC-I Proteins HFE and HLA-C

Authors: Sepideh Mikaeeli, Ali Ben Djoudi Ouadda, Alexandra Evagelidis, Rachid Essalmani, Oscar Henrique Pereira Ramos, Carole Fruchart-Gaillard, Nabil G Seidah

Journal: Cells

PubMed ID: 38786080

Doi: 10.3390/cells13100857

Products & Services: Mutant Libraries