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PolySUMOylation of PCNA and Rad52 restricts centromeric recombination in fission yeast

Authors: Katarzyna Markowska, Ireneusz Litwin, Dorota Misiorna, Julia Kończak, Aleksandra Bogdańska, Paulina Tomaszewska, Michał Tracz, Mika Haenen, Karol Kramarz

Journal: Nature Communications

PubMed ID: 41330900

Doi: 10.1038/s41467-025-65862-1

Products & Services: Gene Synthesis

Constitutive activity of an atypical chemokine receptor revealed by inverse agonistic nanobodies

Authors: Claudia V Perez Almeria, Omolade Otun, Roman Schlimgen, Thomas D Lamme, Lotte Di Niro, Caitrin Crudden, Jan Paul Bebelman, Noureldine Youssef, Lejla Musli, Shawn Jenjak, Vladimir Bobkov, Julia Drube, Carsten Hoffmann, Brian F Volkman, Sébastien Granier, Cherine Bechara, Marco Siderius, Raimond Heukers, Christopher T Schafer, Martine J Smit

Journal: Nature Communications

PubMed ID: 41330916

Doi: 10.1038/s41467-025-65858-x

Products & Services: Codon Optimization

A bypass gateway from cholesterol to sex steroid biosynthesis circumnavigates CYP17A1

Authors: Ziqi Zhu, Yoon-Mi Chung, Mohammad Alyamani, Yijing Dai, Kevin D McCarty, Evan Roberts, Sunita Sinha, Jianneng Li, Xiuxiu Li, Emad M Gad, Zhiqun Zhou, Jinyuan Shi, Robert A Burgess, Tatiana Y Hargrove, Galina I Lepesheva, F Peter Guengerich, Richard J Auchus, Nima Sharifi

Journal: Nature Communications

PubMed ID: 41345099

Doi: 10.1038/s41467-025-66558-2

Products & Services: CRISPR Plasmids

β-sheet stabilization of the island domain underlies ligand-induced LRR-RP activation of plant immune signaling

Authors: Simon Snoeck, Lisha Zhang, Valentin Studer, Gijeong Kim, Álvaro D Fernández-Fernández, Thorsten Nürnberger, Cyril Zipfel

Journal: Nature Communications

PubMed ID: 41361182

Doi: 10.1038/s41467-025-66119-7

Products & Services: Custom Vector Construction

Diet-induced RKIP downregulation disrupts PC/PE-ER homeostasis to drive MASLD

Authors: Mengjie Li, Qian Ou, Qiang Qin, Jiaxi Chen, Sen Yang, Jie Zhao, Hua Meng, Xu Li, Pinglong Xu, Cunqi Ye, Xiaojian Wang

Journal: Nature Communications

PubMed ID: 41387436

Doi: 10.1038/s41467-025-65982-8

Products & Services: Protein and Antibody Isolation

Distinct components of mRNA vaccines cooperate to instruct efficient germinal center responses

Authors: Diana Castaño, Emily Bettini, Binod Kumar, Aleksey Chudnovskiy, Anna Siv, Giulia Protti, Sandra Nakadakari-Higa, Simona Ceglia, Nina De Luna, Joy E Chiu, Katlyn Lederer, Shuk Hang Li, Hassaan Ibrahim, Hiromi Muramatsu, Thandiswa Mdluli, Edit Abraham, Sinem E Sahingur, Ivan Maillard, Ying K Tam, Sunny Shin, Scott E Hensley, Jonathan J Miner, Zoltan Lipinszki, Andrea Reboldi, Norbert Pardi, Roberto Spreafico, Gabriel D Victora, Michela Locci

Journal: Cell

PubMed ID: 41406961

Doi: 10.1016/j.cell.2025.11.023

The resting and ligand-bound states of the membrane-embedded human T-cell receptor–CD3 complex

Authors: Ryan Q Notti, Fei Yi, Søren Heissel, Martin W Bush, Zaki Molvi, Pujita Das, Henrik Molina, Christopher A Klebanoff, Thomas Walz

Journal: Nature Communications

PubMed ID: 41402338

Doi: 10.1038/s41467-025-66939-7

A genome-wide CRISPR screen identifies GRA38 as a key regulator of lipid homeostasis during Toxoplasma gondii adaptation to lipid-rich conditions

Authors: Mebratu A Bitew, Tatiana C Paredes-Santos, Parag Maru, Shruthi Krishnamurthy, Yifan Wang, Lamba O Sangaré, Samuel Duley, Yoshiki Yamaryo-Botté, Cyrille Y Botté, Jeroen P J Saeij

Journal: Nature Communications

PubMed ID: 41407671

Doi: 10.1038/s41467-025-66137-5

Products & Services: Protein and Antibody Isolation

Engineered ipilimumab variants that bind human and mouse CTLA-4

Authors: Brett Robison 1, S J Diong 1, Anusha Kumar 1, Thomas M Moon , Olin Chang , Bryant Chau , Christine Bee , Ishita Barman , Arvind Rajpal , Alan J Korman , Sean West , Pavel Strop , Peter S Lee

Journal: MAbs

PubMed ID: 39849917

Doi: 10.1080/19420862.2025.2451296

Products & Services: Combinatorial Mutant library

The prion-like characteristic of ORF3 contributes to virion release and pathogenesis of hepatitis E virus

Authors: Yajing Wang, Houlu Tian, Na Shi, Chunyan Wu, Yaowei Huang, Yongling Yang, Qiang Ding, Xu Zheng, Qin Zhao, Zhaonong Hu, Jiaojiao Luo, Lele Feng, Lingdong Xu, Mick F Tuite, Hongying Chen, Yuchen Nan

Journal: Proceedings of the National Academy of Sciences of the United States of America

PubMed ID: 41343667

Doi: 10.1073/pnas.2511801122

Products & Services: Polyclonal Antibody Services