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Modeling and addressing on-target/off-tumor toxicity of claudin 18.2 targeted immunotherapies

Authors: Elizabeth J Carstens, Kazuki Takahashi, Naoya Sakamoto, Martina De Vizio, Micaela Morgado, Shahryar Khoshtinat Nikkhoi, Abhishek Mangipudi, Canh Hiep Nguyen, Tate Weltzin, Izuma Nakayama, Qiang Lv, Jue Zeng, Cui Nie, Changjing Deng, Xiaoxiao Wang, Lile Liu, Samuel J Klempner, Anusuya Ramasubramanian, Jonathan A Nowak, Andrew J Aguirre, Kohei Shitara, Eric L Smith

Journal: Nature Communications

PubMed ID: 41176582

Doi: 10.1038/s41467-025-65148-6.

Products & Services: Recombinant Proteins

Pmt4 recognizes two separate acceptor sites to O-mannosylate in the S/T-rich regions of substrate proteins

Authors: Minge Du, Zuanning Yuan, Amanda Kovach, Meinan Lyu, Huilin Li

Journal: Nature Communications

PubMed ID: 41188226

Doi: 10.1038/s41467-025-64729-9.

Products & Services: Protein and Antibody Isolation

StealTHY: An immunogen-free CRISPR platform to expose concealed metastasis regulators in immunocompetent models

Authors: Massimo Saini, Francesc Castro-Giner, Adriana Hotz, Magdalena K Sznurkowska, Manuel Nüesch, François M Cuenot, Selina Budinjas, Gilles Bilfeld, Ece Su Ildız, Karin Strittmatter, Ilona Krol, Zoi Diamantopoulou, Aino Paasinen-Sohns, Maria Waldmeier, Rafaela Cássio, Susanne Kreutzer, Zacharias Kontarakis, Ana Gvozdenovic, Nicola Aceto

Journal: Cell

PubMed ID: 41205600

Doi: 10.1016/j.cell.2025.10.007.

Products & Services: Gene Synthesis

Bidirectional communication between nucleotide and substrate binding sites in a type IV multidrug ABC transporter

Authors: Victor Hugo Pérez Carrillo, Margot Di Cesare, Dania Rose-Sperling, Waqas Javed, Hannes Neuweiler, Julien Marcoux, Cédric Orelle, Jean-Michel Jault, Ute A Hellmich

Journal: Nature Communications

PubMed ID: 41219214

Doi: 10.1038/s41467-025-65037-y.

A bispecific antibody targeting PD-L1/TNFR2 increases tumor targeting and enhances antitumor efficacy in colorectal cancer

Authors: Xiaozhen Kang, Peng Qian, Yifeng Han, Mengdi Wu, Yuxin Li, Chun Xu, Jiwu Wei

Journal: Journal for ImmunoTherapy of Cancer

PubMed ID: 41238220

Doi: https://doi.org/10.1136/jitc-2025-013001

Products & Services: Catalog Antibodies

Early CD4+ T-cell immune reconstitution as a biomarker for Epstein-Barr virus control following allogeneic transplantation

Authors: Kexin Lin, Wenwen Yang, Jiaxiu Yin, Jing Luo, Hao Zhou, Lanxiang Liu, Li Yang, Jie Luo, Lin Liu, Junli Mou

Journal: Blood research

PubMed ID: 41186900

Doi: 10.1007/s44313-025-00106-1

Products & Services: Molecular Biology Reagents

Double-stranded DNA deaminase DddAE1347A can increase the efficiency and targeting range of cytidine base editors

Authors: Yuqiang Qian, Fengjiao Hui, Wenchao Niu, Di Wang, Yang Hao, Qingying Meng, Siyu Ren, Deqiang Kong, Heng Gong, Jiayu Wu, Kexin Chen, Muna Alariqi, Junping Gao, Zhanjun Li, Shuangxia Jin

Journal: Genome Biology

PubMed ID: 41250247

Doi: 10.1186/s13059-025-03849-3

Products & Services: CRISPR RNAs/Cas9 Proteins(INACTIVE)

Glutathionylated DNA adducts accumulate in mitochondrial DNA and are regulated by AP endonuclease 1 and tyrosyl-DNA phosphodiesterase 1

Authors: Yu Hsuan Chen, Martin Esparza Sanchez, Ta I Hung, Jin Tang, Wenyan Xu, Jiekai Yin, Yinsheng Wang, Chia-En A Chang, Huimin Zhang, Junjie Chen, Linlin Zhao

Journal: Proceedings of the National Academy of Sciences of the United States of America

PubMed ID: 41259143

Doi: doi.org/10.1073/pnas.2509312122

Products & Services: Catalog Antibodies

Engineering Multicellular Inter-communication Systems Using a Synthetic Homodimer-inducible Kinase Receptor

Authors: Quan Zhang, Miao Zhang, Yao Zhang, Fenglin Wang, Jian-Hui Jiang

Journal: Angewandte Chemie (International ed. in English)

PubMed ID: 41267507

Doi: 10.1002/anie.202513254

Products & Services: PCR Cloning and Subcloning DNA Sequencing

SLC7A11-independent disulfidptosis induced by a two-pronged delivery strategy for bladder cancer chemotherapy and cisplatin-resistance reverse

Authors: Bin Zheng, Facai Zhang, Heng Wang, Wenyan Zuo, Dingyi Liu, Zhihan Wu, Zhenghong Liu, Haichang Li, Yang Liu, Yixuan Mou, Xiaowen Qin, Dahong Zhang, Pu Zhang, Qi Zhang

Journal: Materials today. Bio

PubMed ID: 41322137

Doi: 10.1016/j.mtbio.2025.102547

Products & Services: Protein and Antibody Isolation