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The resting and ligand-bound states of the membrane-embedded human T-cell receptor–CD3 complex

Authors: Ryan Q Notti, Fei Yi, Søren Heissel, Martin W Bush, Zaki Molvi, Pujita Das, Henrik Molina, Christopher A Klebanoff, Thomas Walz

Journal: Nature Communications

PubMed ID: 41402338

Doi: 10.1038/s41467-025-66939-7

Distinct components of mRNA vaccines cooperate to instruct efficient germinal center responses

Authors: Diana Castaño, Emily Bettini, Binod Kumar, Aleksey Chudnovskiy, Anna Siv, Giulia Protti, Sandra Nakadakari-Higa, Simona Ceglia, Nina De Luna, Joy E Chiu, Katlyn Lederer, Shuk Hang Li, Hassaan Ibrahim, Hiromi Muramatsu, Thandiswa Mdluli, Edit Abraham, Sinem E Sahingur, Ivan Maillard, Ying K Tam, Sunny Shin, Scott E Hensley, Jonathan J Miner, Zoltan Lipinszki, Andrea Reboldi, Norbert Pardi, Roberto Spreafico, Gabriel D Victora, Michela Locci

Journal: Cell

PubMed ID: 41406961

Doi: 10.1016/j.cell.2025.11.023

SnRK2.5-mediated phosphorylation of PIN2 links osmotic stress signaling with auxin dependent root adaptive growth in Arabidopsis

Authors: Shujuan Zhang, Zilong Cui, Yu Gao, Qi Liao, Wenyan Li, Siqi Yuan, Zhuomeng Li, Xinwen Zhang, Kai Ding, Wenjing Zhang, Like Shen, Jörg Kudla, Wenhua Zhang, Jing Zhang, Qun Zhang

Journal: Molecular Plant

PubMed ID: 41353562

Doi: 10.1016/j.molp.2025.12.002

Products & Services: Protein and Antibody Isolation Catalog Antibodies

Discovery of novel pyrrolidine-2,5-dione scaffold PICK1 PDZ inhibitors as anti-ischemic stroke agents

Authors: Yichen Jiang, Qi Liu, Ting Zhu, Ruiguo Liang, Yujiao Qin, Xiya Guo, Jiacheng Wang, Ping Li, Jie Zhou, Han Ju, Mingxin Dong

Journal: European Journal of Medicinal Chemistry

PubMed ID: 41386205

Doi: 10.1016/j.ejmech.2025.118410

Products & Services: Plasmid DNA Preparation

Native cell niche-inspired multiorder nanoassemblies orchestrate integrated interaction networks to guide muscle regeneration

Authors: Peng Lou, Yizhuo Wang, Yimeng Zhang, Xiyue Zhou, Lan Li, Shuyun Liu, Meihua Wan, Yanrong Lu, Jingping Liu

Journal: Molecular therapy: the journal of the American Society of Gene Therapy

PubMed ID: 41445187

Doi: 10.1016/j.ymthe.2025.12.044

Products & Services: Catalog IVT RNA products Custom mRNA synthesis

The Artemisia argyi oil reduces high-fat diet-induced obesity by enhancing thermogenesis in brown adipose tissue

Authors: Shuai Wang, ShengLan Lin, Fuan Xie, Shuting Liu, Ting He, Kun Chen, Zhengrong Huang, Wenlong Xie, Hongqiu Cheng, Jian Zhang, Weihua Li

Journal: NPJ science of food

PubMed ID: 41390517

Doi: 10.1038/s41538-025-00633-2

Products & Services: Molecular Biology Reagents Catalog Antibodies

The extracellular domain of mGluR6 regulates targeting to the conventional secretion pathway

Authors: Andrew P Rideout, Omar W Abuelatta, Melina A Agosto

Journal: Molecular and cellular neurosciences

PubMed ID: 41448371

Doi: 10.1016/j.mcn.2025.104068

Products & Services: Protein and Antibody Isolation

A broadly neutralizing antibody confers cross-genus protection against alphaherpesviruses by inhibiting gB-mediated membrane fusion

Authors: Guosong Wang, Yu Li, Chongxin Wu, Tian Chen, Mengxuan Gui, Yue Zeng, Hui Sun, Kaiyun Chen, Xiangfeng Xi, Yanbo Yang, Yuchen Jiang, Yanan Jiang, Liqin Liu, Chengyu Yang, Jiarui Xin, Caihong Liu, Yiyi Li, Ningning Huo, Yang Huang, Lina Lin, Hai Yu, Chenghao Huang, Quan Yuan, Shaowei Li, Kegong Tian, Qingbing Zheng, Ningshao Xia, Yixin Chen

Journal: Nature Communications

PubMed ID: 41402251

Doi: 10.1038/s41467-025-66099-8

Products & Services: Antibody Modification and Purification Services

Gene-corrected regulatory T cell therapy for IL2RA deficiency

Authors: Alvin S Ha, Nechama Kalter, Michael Rosenberg, Luis A Acevedo, Brianna Liang, Weihong Liu, Sreenivasan Paruthiyil, Meenal Sinha, Alexander Vu, Vinh Nguyen, Zhongxia Qi, Netravathi Krishnappa, Jinna Shu, Jingwei Yu, Jason Catanzaro, Jeffrey A Bluestone, Qizhi Tang, Fyodor D Urnov, Alexander Marson, Ayal Hendel, Kevan C Herold, Brian R Shy, Jonathan H Esensten

Journal: Molecular Therapy

PubMed ID: 41376159

Doi: 10.1016/j.ymthe.2025.12.004

Products & Services: Molecular Biology Reagents

Structural insights into kainate receptor desensitization

Authors: Changping Zhou, Guadalupe Segura-Covarrubias, Nami Tajima

Journal: Nature Communications

PubMed ID: 41365859

Doi: 10.1038/s41467-025-65920-8