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A highly active Burkholderia polyketoacyl-CoA thiolase for production of triacetic acid lactone

Authors: Zilong Wang, Seokjung Cheong, Jose Henrique Pereira, Weixi Hu, Yifan Guo, Andy DeGiovanni, Guangxu Lan, Jinho Kim, Robert W Haushalter, Taek Soon Lee, Paul D Adams, Jay D Keasling

Journal: Nature Communications

PubMed ID: 41365852

Doi: 10.1038/s41467-025-65946-y

TBK1 Induces the Formation of Optineurin Filaments That Condensate with Polyubiquitin and LC3 for Cargo Sequestration

Authors: Maria G Herrera, Lena Kühn, Lisa Jungbluth, Verian Bader, Laura J Krause, David Kartte, Elias Adriaenssens, Sascha Martens, Jörg Tatzelt, Carsten Sachse, Konstanze F Winklhofer

Journal: Advanced Science

PubMed ID: 41405403

Doi: 10.1002/advs.202509927

Structural basis of microtubule-mediated signal transduction

Authors: Sung Ryul Choi, Thorsten B Blum, Matteo Giono, Bibhas Roy, Ioannis Vakonakis, Dominic Schmid, Nicole Oelgarth, Apisha Ranganathan, Alvar D Gossert, G V Shivashankar, Alfred Zippelius, Michel O Steinmetz

Journal: Cell

PubMed ID: 41365297

Doi: 10.1016/j.cell.2025.11.011

ApoE2-DARPin fusion proteins enable selective RNA transfer to CD8 T cells by lipid nanoparticles

Authors: Samuel A Theuerkauf, Luca J Zinser, Nandini Sheth, Elham Adabi, Lea R Knapp, Johanna M Gorol, Sascha Hein, Angeliki Chroni, Frederic B Thalheimer, Christian J Buchholz

Journal: Journal of controlled release

PubMed ID: 41197834

Doi: 10.1016/j.jconrel.2025.114377

Products & Services: Catalog IVT RNA products

Synthesis of Bispecific Conjugates by ADP-Ribosyl Cyclases

Authors: Sunny H Kim, Arshad J Ansari, Lei Zhang, Guoyun Kao, Thuc Oanh Hoang, Zeyu Zhang, Srinivasarao Singireddi, Benjamin B Katz, Yong Zhang

Journal: Advanced Science

PubMed ID: 41422434

Doi: 10.1002/advs.202518329

Products & Services: Protein and Antibody Isolation

A dsRNA Viral Transcriptional Regulator Evades Innate Immunity by Hijacking Host CoTranscription Factor DHX9

Authors: Xueyang Pang, Shiyu Liu, Yixiao Zhu, Meleana M Hinchman, Nan Qiao, Xuejun Li, Weiqian Dai, Yingying Tong, Man Xing, Jiling Ren, John S L Parker, Yingying Guo, Dongming Zhou

Journal: Advanced Science

PubMed ID: 41431149

Doi: 10.1002/advs.202512262

Products & Services: Catalog Peptides

Nuclear speckle proteins form intrinsic and MALAT1-dependent microphases

Authors: Min Kyung Shinn, Dylan T Tomares, Vicky Liu, Avnika Pant, Yuanxin Qiu, Andreas Vitalis, You Jin Song, Yuna Ayala, Kiersten M Ruff, Gregory W Strout, Matthew D Lew, Kannanganattu V Prasanth, Rohit V Pappu

Journal: Cell

PubMed ID: 41421357

Doi: 10.1016/j.cell.2025.11.026

Engineered ipilimumab variants that bind human and mouse CTLA-4

Authors: Brett Robison 1, S J Diong 1, Anusha Kumar 1, Thomas M Moon , Olin Chang , Bryant Chau , Christine Bee , Ishita Barman , Arvind Rajpal , Alan J Korman , Sean West , Pavel Strop , Peter S Lee

Journal: MAbs

PubMed ID: 39849917

Doi: 10.1080/19420862.2025.2451296

Products & Services: Combinatorial Mutant library

The prion-like characteristic of ORF3 contributes to virion release and pathogenesis of hepatitis E virus

Authors: Yajing Wang, Houlu Tian, Na Shi, Chunyan Wu, Yaowei Huang, Yongling Yang, Qiang Ding, Xu Zheng, Qin Zhao, Zhaonong Hu, Jiaojiao Luo, Lele Feng, Lingdong Xu, Mick F Tuite, Hongying Chen, Yuchen Nan

Journal: Proceedings of the National Academy of Sciences of the United States of America

PubMed ID: 41343667

Doi: 10.1073/pnas.2511801122

Products & Services: Polyclonal Antibody Services

Targeting SKAP2 restores sperm motility and morphology through modulating mitochondrial organization and cytoskeletal remodeling

Authors: Shiming Gan, Lin Yin, Jiaming Zhou, Sisi Li, Shumin Zhou, Xiaotong Yang, Rui Liu, Xu Fan, Yangyang Li, Zhendong Yao, Jingshou Chen, Peiran Hu, Wenjing Xiong, Yuan Yuan, Yujiao Wen, Youjiang Li, Ge Jin, Jianzhong Sheng, Yuzhen Gao, Hefeng Huang, Chen Zhang

Journal: Signal transduction and targeted therapy

PubMed ID: 41436426

Doi: 10.1038/s41392-025-02513-3

Products & Services: Protein and Antibody Isolation