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WDR5 remodels NANOG condensates to drive transcriptional programs and sustain stem cell identity

Authors: Duo Wang, Xianle Shi, Jiaying Xie, Lijie Zhao, Bin Wu, Qiman Dong, Yaoguang Huang, Jinlong Suo, Xinyu Wang, Beixuan He, Shukun Yan, Hongjuan Xue, Yuheng Shi, Yingbin Liu, Jianlong Wang, Yong Chen, Yanjing Li

Journal: Nature Communications

PubMed ID: 41565645

Doi: 10.1038/s41467-026-68623-w

Products & Services: Custom DNA/RNA Oligos

An integrated valved microfluidic platform for rapid and simultaneous nucleic acid detection

Authors: Zihan Wang, Fuwan Yang, Shuai Zeng, Rui Sun, Qifei Hu, Yichen Du

Journal: Lab on a chip

PubMed ID: 41439322

Doi: 10.1039/D5LC01096A

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Microbiota-induced T cell plasticity enables immune-mediated tumour control

Authors: Tariq A Najar, Yuan Hao, Yuhan Hao, Gabriela Romero-Meza, Alexandra Dolynuk, Emma Almo, Dan R Littman

Journal: Nature

PubMed ID: 41535459

Doi: 10.1038/s41586-025-09913-z

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Stress controls heterochromatin inheritance via histone H3 ubiquitylation

Authors: Bharat Bhatt, Yi Wei, Ashis Kumar Pradhan, Jothy Dhakshnamoorthy, Martin Zofall, Hua Xiao, Drisya Vijayakumari, Shweta Jain, Hernan Diego Folco, Hongyun Qi, David A Ball, Tatiana S Karpova, David Wheeler, Jiemin Wong, Shiv I S Grewal

Journal: Nature

PubMed ID: 41501458

Doi: 10.1038/s41586-025-09899-8

Products & Services: Protein and Antibody Isolation

Cooperativity and communication between the active sites of the dimeric SARS-CoV-2 main protease

Authors: Sarah N Zvornicanin, Ala M Shaqra, Julia Flynn, Lauren E Intravaia, Heidi Carias Martinez, Weiping Jia, Devendra Kumar Gupta, Stephanie Moquin, Dustin Dovala, Daniel N Bolon, Brian A Kelch, Celia A Schiffer, Nese Kurt Yilmaz

Journal: SCIENCE ADVANCES

PubMed ID: 41544157

Doi: 10.1126/sciadv.aeb0769

Products & Services: Molecular Biology Reagents

TIGIT disruption rescues the antitumor activity of low avidity TCR-engineered T cells by increasing TCR signal strength

Authors: Martina Spiga, Alessia Potenza, Zulma Magnani, Stefano Beretta, Barbara Camisa, Laura Conte, Alessia Airaghi, Neda Mohammadi, Laura Perani, Claudio Doglioni, Maurilio Ponzoni, Francesca Sanvito, Chiara Balestrieri, Lucia Sergi Sergi, Oronza A Botrugno, Giulio Giovannoni, Giovanni Tonon, Danilo Abbati, Chiara Iozzi, Maximilian Reichert, Hana Algul, Arianna Pocaterra, Martina Fiumara, Samuele Ferrari, Alessia Ugolini, Alice Grometto, Giulia Di Lullo, Giovanni Sitia, Giulio Belfiori, Maria Pia Protti, Renato Ostuni, Anna Mondino, Michele Reni, Stefano Crippa, Massimo Falconi, Luigi Naldini, Eliana Ruggiero, Chiara Bonini

Journal: Nature Communications

PubMed ID: 41507193

Doi: 10.1038/s41467-025-67263-w

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Arboviruses manipulate rice’s volatile emissions, protecting insect vectors from natural enemies in the field

Authors: Qing Liu, Qian Wang, Qiong Li, Weiran Wang, Qi Li, Ziyuan Peng, Yuling Jiao, Feng Cui, Ian T Baldwin, Xiaoming Zhang

Journal: SCIENCE ADVANCES

PubMed ID: 41499511

Doi: 10.1126/sciadv.aeb5215

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FLIPs: Genetically encoded molecular biosensors for functional imaging of cell signaling by linear dichroism microscopy

Authors: Paul Miclea, Vendula Nagy-Marková, Robin Van den Eynde, Wim Vandenberg, Alina Sakhi, Alexey Bondar, Jitka Myšková, Peter Dedecker, Josef Lazar

Journal: SCIENCE ADVANCES

PubMed ID: 41544164

Doi: 10.1126/sciadv.adz5662

Products & Services: Gene Synthesis

Optimally engineered HLA/peptide-specific CAR-T cells outperform TCR-T cells to eradicate solid tumors

Authors: Corinne E Decker, Jacqueline Idun, Katja Mohrs, Thomas Craig Meagher, Iryna Petriv, Jonathon Golas, Robert Salzler, Timothy Helms, Dharani Ajithdoss, Suhasini Avvaru, Jiaxi Wu, Tong Zhang, Eric Smith, Gavin Thurston, John C Lin, Jessica R Kirshner, David J DiLillo

Journal: SCIENCE ADVANCES

PubMed ID: 41564177

Doi: 10.1126/sciadv.adx9371

Products & Services: Gene Synthesis

Dyslipidaemia-associated natural IgM improves oncolytic virus TILT-123 efficacy through antibody-dependent enhancement in solid tumours.

Authors: James Hugo Armstrong Clubb, Santeri Artturi Pakola, Sakari Joenväärä, Tatiana Viktorovna Kudling, Tiialotta Tohmola, Victor Arias, Elise Jirovec, Mirte van der Heijden, Dafne Carolina Alves Quixabeira, Annukka Pasanen, Lyna Haybout, Nea Ojala, Saru Basnet, Arianna Eleuteri, Julia Davila Ferrero, Stella Hirvenoja, Inge Marie Svane, Johanna Mäenpää, Katriina Jalkanen, Matthew Stephen Block, Tuomo Alanko, Tine Monberg, Sanae Zahraoui, Susanna Grönberg-Vähä-Koskela, Natasha Salmelin, Claudia Kistler, Riikka Havunen, Suvi Sorsa, João Manuel Dos Santos, Victor Cervera-Carrascon, Anna Kanerva, Otto Hemminki, Risto Renkonen, Akseli Hemminki

Journal: Molecular Therapy

PubMed ID: 41566775

Doi: 10.1016/j.ymthe.2026.01.019

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