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Re-appraising assays on permeabilized blood cancer cells testing venetoclax or other BH3 mimetic agents selectively targeting pro-survival BCL2 proteins

Authors: Jia-Nan Gong, Tirta M Djajawi, Donia M Moujalled, Giovanna Pomilio, Tiffany Khong, Li-Ping Zhang, Pasquale L Fedele, Michael S Low, Mary Ann Anderson, Christopher D Riffkin, Christine A White, Ping Lan, Guillaume Lessene, Marco J Herold, Andreas Strasser, Andrew Spencer, George Grigoriadis, Andrew H Wei, Mark F van Delft, Andrew W Roberts, David C S Huang

Journal: Cell Death & Differentiation

PubMed ID: 40204951

Doi: 10.1038/s41418-025-01487-7

Products & Services: Peptide Synthesis

Discovery of diverse and high-quality mRNA capping enzymes through a language model–enabled platform

Authors: Tianze Wang, Bowen R Qin, Sihong Li, Zimo Wang, Xuejian Li, Yuanxu Jiang, Chenrui Qin, Qi Ouyang, Chunbo Lou, Long Qian

Journal: SCIENCE ADVANCES

PubMed ID: 40203090

Doi: 10.1126/sciadv.adt0402

Products & Services: Gene Synthesis

Mechanistic understanding of UvrA damage detection and lesion hand-off to UvrB in Nucleotide Excision Repair

Authors: Marianna Genta, Giulia Ferrara, Riccardo Capelli, Diego Rondelli, Sarah Sertic, Martino Bolognesi, Menico Rizzi, Franca Rossi, David Jeruzalmi, Antonio Chaves-Sanjuan & Riccardo Miggiano

Journal: Nature Communications

PubMed ID: 40210888

Doi: 10.1038/s41467-025-58670-0

Products & Services: Gene Synthesis

Differential interactions determine anisotropies at interfaces of RNA-based biomolecular condensates

Authors: Nadia A. Erkamp, Mina Farag, Yuanxin Qiu, Daoyuan Qian, Tomas Sneideris, Tingting Wu, Timothy J. Welsh, Hannes Ausserwöger, Tommy J. Krug, Gaurav Chauhan, David A. Weitz, Matthew D. Lew, Tuomas P. J. Knowles & Rohit V. Pappu

Journal: Nature Communications

PubMed ID: 40216775

Doi: 10.1038/s41467-025-58736-z

Controlled and orthogonal partitioning of large particles into biomolecular condensates

Authors: Fleurie M. Kelley, Anas Ani, Emily G. Pinlac, Bridget Linders, Bruna Favetta, Mayur Barai, Yuchen Ma, Arjun Singh, Gregory L. Dignon, Yuwei Gu & Benjamin S. Schuster

Journal: Nature Communications

PubMed ID: 40229261

Doi: 10.1038/s41467-025-58900-5

Products & Services: Custom Vector Construction

Molecular basis of human GABA transporter 3 inhibition

Authors: Ravi Yadav, Gye Won Han, Cornelius Gati

Journal: Nature Communications

PubMed ID: 40268946

Doi: 10.1038/s41467-025-59066-w

Products & Services: Gene Synthesis

Zonated Copper-Driven Breast Cancer Progression Countered by a Copper-Depleting Nanoagent for Immune and Metabolic Reprogramming

Authors: Lin Chen, Saibo Ma, Hao Wu, Lingna Zheng, Yunpeng Yi, Guangnian Liu, Baoyi Li, Jiayi Sun, Yang Du, Bing Wang, Yike Liu, Cheng Zhang, Jing Chang, Yuheng Pang, Wenjing Wang, Meng Wang, Motao Zhu

Journal: Advanced Science

PubMed ID: 40270472

Doi: 10.1002/advs.202412434

Products & Services: Recombinant Proteins

Sequence and taxonomic feature evaluation facilitated the discovery of alcohol oxidases

Authors: Yilei Han, Xuwei Ding, Junjian Tan, Yajuan Sun, Yunjiang Duan, Zheng Liu, Gaowei Zheng, Diannan Lu

Journal: Synthetic and Systems Biotechnology

PubMed ID: 40386440

Doi: doi.org/10.1016/j.synbio.2025.04.014

Products & Services: Molecular Biology Reagents

Inhibition of CHI3L1 attenuates excessive autophagy in intestinal epithelial cells to reduce the severity of necrotizing enterocolitis

Authors: Yihui Li, Wenqiang Sun, Xinyun Jin, Huiwen Li, Xue Liu, Jingtao Bian, Xueping Zhu

Journal: Cell Death Discov

PubMed ID: 40188090

Doi: 10.1038/s41420-025-02443-7.

Products & Services: Protein and Antibody Isolation

Nanosized Shikonin Disrupts Tumor-cell Mismatch Repair and Synergizes with Manganese to Sensitize Squamous Carcinoma to Immunotherapy

Authors: Shan Yu, Jingyuan Li, Jie Zhang, Guozhong Zeng, Bin Zeng, Shuyuan Song, Zhentao Lao, Haolin Chen, Zhenfu Wen, Zeyu Yang, Xiang Li, Kan Li, Le Yang, Hong Liu, Lixin Liu, Guiqing Liao, Yongming Chen, Yujie Liang

Journal: ACS Nano

PubMed ID: 40190094

Doi: 10.1021/acsnano.4c17090.

Products & Services: Protein and Antibody Isolation