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N-Terminal random curl-tandam α-helical peptide 7W: A potent antibacterial and anti-inflammatory dual-effect agent through tryptophan substitution

Authors: Jietao Lou, Xinyi Wu, Wenwen Ji, Jiaye Yu, Yanyan Xu, Wanyang Xiao, Weijie Lu, Kaiyun Xin, Tianbao Chen, Qidong Tang, Guang Liang, Yitian Gao, Di Wu

Journal: Eur J Med Chem

PubMed ID: 40319576

Doi: 10.1016/j.ejmech.2025.117686

Products & Services: Peptide Synthesis

Fullerol Initiates Stem Cell–Nanomaterials Interactions for Enhanced Tissue Regeneration via Clathrin-Mediated Endocytosis and Nuclear Factor Erythroid 2-Related Factor 2 Signaling

Authors: Haoyang Liu, Yue Zhu, Weixu Chen, Renwang Sheng, Chuanquan Liu, Yuzhi Sun, Jia Liu, Mingyue Wang, Jun Lu, Jialin Chen, Wei Zhang

Journal: ACS Applied Materials & Interfaces

Doi: 10.1021/acsami.5c01731

Products & Services: Recombinant Proteins

Targeted Delivery of mRNA with Polymer−Lipid Nanoparticles for In Vivo Base Editing

Authors: Qimingxing Chen, Yan Chang, Xiaoyan He, Yan Ding, Runyuan Wang, Ran Luo, Jialu Yuan, Jiabei Chen, Guisheng Zhong, Huiying Yang, Jia Chen, Jianfeng Li

Journal: ACS Nano

PubMed ID: 39962883

Doi: 10.1021/acsnano.4c14041

Products & Services: Custom DNA/RNA Oligos Synthetic Guide RNA

PIN1-SUMO2/3 motif suppresses excessive RNF168 chromatin accumulation and ubiquitin signaling to promote IR resistance

Authors: Anoop S Chauhan, Matthew J W Mackintosh, Joseph Cassar, Alexander J Lanz, Mohammed Jamshad, Hannah L Mackay, Alexander J Garvin, Alexandra K Walker, Satpal S Jhujh, Teresa Carlomagno, Aneika C Leney, Grant S Stewart, Joanna R Morris

Journal: nature COMMUNICATION

PubMed ID: 40229270

Doi: 10.1038/s41467-025-56974-9

Products & Services: Peptide Synthesis Monoclonal Antibody Services

Inhibitor-based modulation of huntingtin aggregation mechanisms mitigates ﬁbrilinduced cellular stress

Authors: Greeshma Jain, Marina Trombetta-Lima, Irina Matlahov, Hennrique Taborda Ribas, Tingting Chen, Raffaella Parlato, Giuseppe Portale, Amalia M. Dolga & Patrick C. A. van der Wel

Journal: Nat Commun

PubMed ID: 40234398

Doi: 10.1038/s41467-025-58691-9

Products & Services: Plasmid DNA Preparation Catalog Antibodies

Lecanemab preferentially binds to smaller aggregates present at early Alzheimer's disease

Authors: Emre Fertan; Jeff Y. L. Lam; Giulia Albertini; Maarten Dewilde; Yunzhao Wu; Oluwatomi E. S. Akingbade; Dorothea B ken; Elizabeth A. English; Bart De Strooper; David Klenerman

Journal: Alzheimer's & Dementia

PubMed ID: 40237235

Doi: 10.1002/alz.70086

Products & Services: Protein and Antibody Isolation

Exploring the potential of selective FKBP51 inhibitors on melanoma: an investigation of their in vitro and in vivo effects

Authors: Laura Marrone; Valeria Di Giacomo; Chiara Malasomma; Marialuisa Alessandra Vecchione; Felix Hausch; Massimiliano Cacace; Lucia D Esposito; Martina Tufano; Paolo D Arrigo; Maria Fiammetta Romano; Simona Romano

Journal: Cell death discovery

PubMed ID: 40180895

Doi: 10.1038/s41420-025-02430-y

Products & Services: Custom Vector Construction

Discovery of SARS-CoV-2 Papain-like Protease Inhibitors through a Combination of High-Throughput Screening and a FlipGFP-Based Reporter Assay

Authors: Chunlong Ma; Michael Dominic Sacco; Zilei Xia; George Lambrinidis; Julia Alma Townsend; Yanmei Hu; Xiangzhi Meng; Tommy Szeto; Mandy Ba; Xiujun Zhang; Maura Gongora; Fushun Zhang; Michael Thomas Marty; Yan Xiang; Antonios Kolocouris; Yu Chen; Jun Wang

Journal: ACS central science

PubMed ID: 34341772

Doi: 10.1021/acscentsci.1c00519

A novel multitargeted self-assembling peptide-siRNA complex for simultaneous inhibition of SARS-CoV-2-host cell interaction and replication

Authors: Martina Tuttolomondo; Stephanie Thuy Duong Pham; Mikkel Green Terp; Virginia Cend n Castillo; Nazmie Kalisi; Stefan Vogel; Niels Langkj r; Ulla Melchior Hansen; Helge Thisgaard; Henrik Daa Schr der; Yaseelan Palarasah; Henrik J rn Ditzel

Journal: Molecular therapy. Nucleic acids

PubMed ID: 38939051

Doi: 10.1016/j.omtn.2024.102227

Products & Services: Peptide Synthesis

A novel multitargeted self-assembling peptide-siRNA complex for simultaneous inhibition of SARS-CoV-2-host cell interaction and replication

Journal: Molecular therapy. Nucleic acids

PubMed ID: 38939051

Doi: 10.1016/j.omtn.2024.102227

Products & Services: Peptide Synthesis