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页码: 116/5356 每页显示数量

LLPS REDIFINE allows the biophysical characterization of multicomponent condensates without tags or labels

Authors: Mihajlo Novakovic, Yaning Han, Nina C Kathe, Yinan Ni, Leonidas Emmanouilidis, Frédéric H-T Allain

Journal: Nature Communications

PubMed ID: 40389460

Doi: 10.1038/s41467-025-59759-2

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Human mitochondrial ferritin exhibits highly unusual iron-O2 chemistry distinct from that of cytosolic ferritins

Authors: Justin M Bradley , Zinnia Bugg , Jacob Pullin , Geoffrey R Moore, Dimitri A Svistunenko , Nick E Le Brun

Journal: Nature Communications

PubMed ID: 40393986

Doi: 10.1038/s41467-025-59463-1

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Cell trajectory modulation: rapid microfluidic biophysical profiling of CAR T cell functional phenotypes

Authors: Kerwin Kwek Zeming, Kai Yun Quek, Wei-Xiang Sin, Denise Bei Lin Teo, Ka-Wai Cheung, Chin Ren Goh, Faris Kairi, Elizabeth Lee, Francesca Lorraine Wei Inng Lim, Michaela Su-Fern Seng, Shui Yen Soh, Michael E Birnbaum, Jongyoon Han

Journal: Nature Communications

PubMed ID: 40404664

Doi: 10.1038/s41467-025-59789-w

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FOXA2 promotes metastatic competence in small cell lung cancer

Authors: Kenta Kawasaki, Sohrab Salehi, Yingqian A Zhan, Kevin Chen, Jun Ho Lee, Eralda Salataj, Hong Zhong, Parvathy Manoj, Dennis Kinyua, Barbara P Mello, Harsha Sridhar, Sam E Tischfield, Irina Linkov, Nicholas Ceglia, Matthew Zatzman, Eliyahu Havasov, Neil J Shah, Fanli Meng, Brian Loomis, Umesh K Bhanot, Esther Redin, Elisa de Stanchina, Pierre-Jacques Hamard, Richard P Koche, Andrew McPherson, Álvaro Quintanal-Villalonga, Sohrab P Shah, Joan Massagué, Charles M Rudin

Journal: Nature Communications

PubMed ID: 40419484

Doi: 10.1038/s41467-025-60141-5

Deletion of the Envelope gene attenuates SARS-CoV-2 infection by altered Spike localization and increased cell-to-cell transmission

Authors: Hannah L. Fischer; Christopher Kline; W. Paul Duprex; Kevin R. McCarthy; Simon C. Watkins; James F. Conway; Zandrea Ambrose

Journal: biorxiv

PubMed ID: 40475451

Doi: 10.1101/2025.05.20.655126

A yeast-based system to study SARS-CoV-2 M pro structure and to identify nirmatrelvir resistant mutations

Authors: Jin Ou; Eric M. Lewandowski; Yanmei Hu; Austin A. Lipinski; Ryan T. Morgan; Lian M.C. Jacobs; Xiujun Zhang; Melissa J. Bikowitz; Paul Langlais; Haozhou Tan; Jun Wang; Yu Chen; John S. Choy

Journal: research square

PubMed ID: 36052369

Doi: 10.21203/rs.3.rs-1942964/v1

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A yeast-based system to study SARS-CoV-2 M pro structure and to identify nirmatrelvir resistant mutations

Authors: Jin Ou; Eric M. Lewandowski; Yanmei Hu; Austin A. Lipinski; Ryan T. Morgan; Lian M.C. Jacobs; Xiujun Zhang; Melissa J. Bikowitz; Paul Langlais; Haozhou Tan; Jun Wang; Yu Chen; John S. Choy

Journal: research square

PubMed ID: 36052369

Doi: 10.21203/rs.3.rs-1942964/v1

Products & Services: Catalog Antibodies

A fluorescence-based assay for measuring polyamine biosynthesis aminopropyl transferase mediated catalysis

Authors: Pallavi Singh; Jae-Yeon Choi; Weiwei Wang; Tukiet T. Lam; Philip Lechner; Christopher D. Vanderwal; Sovitj Pou; Aaron Nilsen; Choukri Ben Mamoun

Journal: The Journal of Biological Chemistry

PubMed ID: 39342998

Doi: 10.1016/j.jbc.2024.107832

Discovery of benzethonium chloride as a potent STAT3 inhibitor for the treatment of HNSCC

Authors: Yuefeng Han; Shumin Li; Deshang Chen; Mingjie Zhang; Guoying Han; QianQian Xu; Xianming Ge; Mengli Wang; Yan Pan; Sien Ma; Beibei Xu; Mengmeng Deng; Bao Zhao

Journal: Frontiers in pharmacology

PubMed ID: 40242440

Doi: 10.3389/fphar.2025.1569570

Products & Services: Protein and Antibody Isolation

Design, synthesis, and mechanism study of dimerized phenylalanine derivatives as novel HIV-1 capsid inhibitors

Authors: Xujie Zhang; Lin Sun; Megan E. Meuser; Waleed A. Zalloum; Shujing Xu; Tianguang Huang; Srinivasulu Cherukupalli; Xiangyi Jiang; Xiao Ding; Yucen Tao; Dongwei Kang; Erik De Clercq; Christophe Pannecouque; Alexej Dick; Simon Cocklin; Xinyong Liu; Peng Zhan

Journal: European Journal of Medicinal Chemistry

PubMed ID: 34592608

Doi: 10.1016/j.ejmech.2021.113848

Products & Services: Peptide Synthesis