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RabE1a- and SEC10b-mediated exocytosis and AP2β-mediated endocytosis are involved in the intracellular transport of tobamoviruses

Authors: Hua-Yu Ma, Yu Kong, Chao Geng, Yan-Ping Tian, Jun Jiang, Zhi-Yong Yan, Xiang-Dong Li

Journal: Plant Biotechnology Journal.

PubMed ID: 40408557

Doi: 10.1111/pbi.70138

Products & Services: Protein and Antibody Isolation

PKMYT1 kinase ameliorates cisplatin sensitivity in osteosarcoma

Authors: Binfeng Liu, Wei Li, Wenchao Zhang, Chengyao Feng, Lu Wan, Shasha He, Ruiling Xu, Zheng Fu, Zhongyue Liu, Haodong Xu, Xin Jin, Chao Tu, Zhihong Li

Journal: Signal Transduct Target Ther

PubMed ID: 40393983

Doi: 10.1038/s41392-025-02250-7

Products & Services: Catalog Antibodies

Structural visualization of HECT-type E3 ligase Ufd4 accepting and transferring

Authors: Xiangwei Wu, Huasong Ai, Junxiong Mao, Hongyi Cai, Lu-Jun Liang, Zebin Tong, Zhiheng Deng, Qingyun Zheng, Lei Liu, Man Pan

Journal: nature COMMUNICATION

PubMed ID: 40341121

Doi: doi.org/10.1038/s41467-025-59569-6

Products & Services: Gene Synthesis Codon Optimization PCR Cloning and Subcloning Mutagenesis Services

Structure-guided design of endosomolytic chloroquine-like lipid nanoparticles for mRNA delivery and genome editing

Authors: Zhen Liu, Jiacai Wu, Ning Wang, Yongqi Lin, Ruiteng Song, Min Zhang, Bin Li

Journal: Nature Communications

PubMed ID: 40335474

Doi: 10.1038/s41467-025-59501-y

Products & Services: Custom RNAi Services

Discovery of benzethonium chloride as a potent STAT3 inhibitor for the treatment of HNSCC

Authors: Yuefeng Han; Shumin Li; Deshang Chen; Mingjie Zhang; Guoying Han; QianQian Xu; Xianming Ge; Mengli Wang; Yan Pan; Sien Ma; Beibei Xu; Mengmeng Deng; Bao Zhao

Journal: Frontiers in pharmacology

PubMed ID: 40242440

Doi: 10.3389/fphar.2025.1569570

Products & Services: Protein and Antibody Isolation

Design, synthesis, and mechanism study of dimerized phenylalanine derivatives as novel HIV-1 capsid inhibitors

Authors: Xujie Zhang; Lin Sun; Megan E. Meuser; Waleed A. Zalloum; Shujing Xu; Tianguang Huang; Srinivasulu Cherukupalli; Xiangyi Jiang; Xiao Ding; Yucen Tao; Dongwei Kang; Erik De Clercq; Christophe Pannecouque; Alexej Dick; Simon Cocklin; Xinyong Liu; Peng Zhan

Journal: European Journal of Medicinal Chemistry

PubMed ID: 34592608

Doi: 10.1016/j.ejmech.2021.113848

Products & Services: Peptide Synthesis

Development of a single-dose Q fever vaccine with an injectable nanoparticle-loaded hydrogel: effect of sustained co-delivery of antigen and adjuvant

Authors: Lu Wang; Aaron Ramirez; Jiin Felgner; Enya Li; Jenny E. Hernandez-Davies; Anthony E. Gregory; Philip L. Felgner; Ali Mohraz; D. Huw Davies; Szu-Wen Wang

Journal: Drug Delivery

PubMed ID: 40314164

Doi: 10.1080/10717544.2025.2476144

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Crystal structure of Alzheimer's disease phospholipase D3 provides a molecular basis for understanding its normal and pathological functions

Authors: Kenta Ishii; Stefan J. Hermans; Maria Eleni Georgopoulou; Tracy L. Nero; Nancy C. Hancock; Gabriela A. N. Crespi; Michael A. Gorman; Jonathan H. Gooi; Michael W. Parker

Journal: The FEBS journal

PubMed ID: 39325669

Doi: 10.1111/febs.17277

SIRT2-mediated deacetylation of LCK governs the magnitude of T cell receptor signaling

Authors: Imene Hamaidi; Pingyan Cheng; Soo Young Jun; Alak Manna; Min-Hsuan Wang; Anh Nguyen; Ismail Can; Min G. Zhang; Odesha O. Taylor; Luis Uriel Lopez Bailon; Bin Fang; Bradford Perez; Ben C. Creelan; Andriy Marusyk; Dongjun Shin; Tae Hyun Hwang; Anders E. Berglund; Virginia S. Shapiro; Haitao M. Ji; Jos R. Conejo-Garcia; Sungjune Kim

Journal: nature immunology

PubMed ID: 41611868

Doi: 10.1038/s41590-025-02377-3

Products & Services: Custom Vector Construction

SIRT2-mediated deacetylation of LCK governs the magnitude of T cell receptor signaling

Journal: nature immunology

PubMed ID: 41611868

Doi: 10.1038/s41590-025-02377-3

Products & Services: Custom Vector Construction