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Cathepsin L-dependent positive selection shapes clonal composition and functional fitness of CD4+ T cells

Authors: Elisabetta Petrozziello, Amina Sayed, João A Freitas, Christine Federle, Jelena Nedjic, Sarina Ravens, Batuhan Akçabozan, Anna M Schulz, Dietmar Zehn, Marc Schmidt-Supprian, Reinhard Obst, Immo Prinz, Martijn Verdoes, Jan Kisielow, Thomas Reinheckel, Tobias Straub, Stephen R Daley, Ludger Klein

Journal: nature immunology

PubMed ID: 40514418

Doi: 10.1038/s41590-025-02182-y

Products & Services: Peptide Synthesis

Cholangiocytes contribute to hepatocyte regeneration after partial liver injury during growth spurt in zebrafish

Authors: Sema Elif Eski, Jiarui Mi, Macarena Pozo-Morales, Gabriel Garnik Hovhannisyan, Camille Perazzolo, Rita Manco, Imane Ez-Zammoury, Dev Barbhaya, Anne Lefort, Frédérick Libert, Federico Marini, Esteban N Gurzov, Olov Andersson, Sumeet Pal Singh

Journal: nature COMMUNICATION

PubMed ID: 40480975

Doi: 10.1038/s41467-025-60334-y

Products & Services: Gene Synthesis

Histidine-Specific Modification of Chitin-Binding protein21 via Visible Light-Mediated C–H Functionalization and Protein Ligation

Authors: Xinliang Liu, Ping Wang and Farong Ye

Journal: CCS Chemistry

Doi: 10.31635/ccschem.024.202404864

Products & Services: Gene Synthesis Plasmid DNA Preparation

High throughput cryo-EM provides structural understanding for modulators of the lysosomal ion channel TRPML1

Authors: Judith Reeks, Pravin Mahajan, Mellissa Clark, Suzanna R Cowan, Elena Di Daniel, Christopher P Earl, Samantha Fisher, Rhian S Holvey, Scott M Jackson, Emyr Lloyd-Evans, Carmine M Morgillo, Paul N Mortenson, Marc O'Reilly, Caroline J Richardson, Patrick Schöpf, Daniel M Tams, Helen Waller-Evans, Simon E Ward, Stuart Whibley, Pamela A Williams, Christopher N Johnson

Journal: Structure

PubMed ID: 40532704

Doi: 10.1016/j.str.2025.05.014

Products & Services: Codon Optimization

Host protein ARF1 is a proviral factor for SARS-CoV-2 and a candidate broad-spectrum therapeutic target

Authors: Cunhuan Zhang, Yuan-Qin Min, Heng Xue, Haiyan Zhang, Kunpeng Liu, Yichao Tian, Ziying Yang, Zihan Zhao, Hang Yang, Chao Shan, Xiulian Sun & Yun-Jia Ning

Journal: nature COMMUNICATION

Doi: 10.1038/s41467-025-61431-8

Products & Services: Peptide Synthesis

Synergistic effects of retinol and retinyl palmitate in alleviating UVB-induced DNA damage and promoting the homologous recombination repair in keratinocytes

Authors: Jiangming Zhong; Ling Liang; Nan Zhao; Jing Wang; Peng Shu

Journal: Frontiers in pharmacology

PubMed ID: 40343007

Doi: 10.3389/fphar.2025.1562244

Products & Services: Protein Electrophoresis and Western

A Chemically Induced CRISPR/dCas13 FCPF Platform for Precise and Programmable RNA Regulation

Authors: Sebastian Hasselbeck; Jianhui Wang; Zhaodai Bai; Tobias H fner; Gerhard Hummer; Phillip Grote; Xinlai Cheng

Journal: Journal of Medicinal Chemistry

PubMed ID: 41122778

Doi: 10.1021/acs.jmedchem.5c01609

A yeast-based system to study SARS-CoV-2 M pro structure and to identify nirmatrelvir resistant mutations

Authors: Jin Ou; Eric M. Lewandowski; Yanmei Hu; Austin A. Lipinski; Ryan T. Morgan; Lian M.C. Jacobs; Xiujun Zhang; Melissa J. Bikowitz; Paul Langlais; Haozhou Tan; Jun Wang; Yu Chen; John S. Choy

Journal: research square

PubMed ID: 36052369

Doi: 10.21203/rs.3.rs-1942964/v1

Products & Services: Catalog Antibodies

A rationally designed injury kidney targeting peptide library and its application in rescuing acute kidney injury

Authors: Yushuo Xiao, Zhijian Tong, Huidie Xu, Zhouyan Jia, Chen Wang, Yang Cao, Liangliang Song, Siyu Hao, Jing Yang, Yihao Zhou, Yunhao Xie, Peng Wu, Tong He, Yancai Wu, Robert B Petersen, Anlin Peng, Chun Zhang, Hong Chen, Ling Zheng, Kun Huang

Journal: SCIENCE ADVANCES

PubMed ID: 40315322

Doi: 10.1126/sciadv.adt3943

Products & Services: Peptide Synthesis

Biomimetic culture substrates for modelling homeostatic intestinal epithelium in vitro

Authors: Sorosh Abdollahi, Bahareh Zarin, Maryam Vatani, Fereshteh Vajhadin, Mohsen Hassani, Pezhman Jalali, Keekyoung Kim, Amir Sanati-Nezhad

Journal: Nature Communications

PubMed ID: 40316543

Doi: 10.1038/s41467-025-59459-x

Products & Services: Molecular Biology Reagents