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spp Omp25 Promotes Proteasome-Mediated cGAS Degradation to Attenuate IFN-β Production

Authors: Ruizhen Li, Wenli Liu, Xiangrui Yin, Fangfang Zheng, Zhenyu Wang, Xingchen Wu, Xiaohua Zhang, Qian Du, Yong Huang, Dewen Tong

Journal: Front Microbiol

PubMed ID: 34394047

Doi: 10.3389/fmicb.2021.702881

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A Covalent Calmodulin Inhibitor as a Tool to Study Cellular Mechanisms of K-Ras-Driven Stemness

Authors: Sunday Okutachi, Ganesh Babu Manoharan, Alexandros Kiriazis, Christina Laurini, Marie Catillon, Frank McCormick, Jari Yli-Kauhaluoma, Daniel Abankwa

Journal: Front Cell Dev Biol

PubMed ID: 34307350

Doi: 10.3389/fcell.2021.665673

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Measuring nonhomologous end-joining, homologous recombination and alternative end-joining simultaneously at an endogenous locus in any transfectable human cell

Authors: Suleman S Hussain, Rahul Majumdar, Grace M Moore, Himanshi Narang, Erika S Buechelmaier, Maximilian J Bazil, Pavithran T Ravindran, Jonathan E Leeman, Yi Li, Manisha Jalan, Kyrie S Anderson, Andrea Farina, Rekha Soni, Neeman Mohibullah, Edin Hamzic, Xiaoqing Rong-Mullins, Christopher Sifuentes, Rama R Damerla, Agnes Viale, Simon N Powell, Daniel S Higginson

Journal: Nucleic Acids Res

PubMed ID: 33877327

Doi: 10.1093/nar/gkab262

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P38α-MAPK phosphorylates Snapin and reduces Snapin-mediated BACE1 transportation in APP-transgenic mice

Authors: Laura Schnöder, Inge Tomic, Laura Schwindt, Dominic Helm, Mandy Rettel, Walter Schulz-Schaeffer, Elmar Krause, Jens Rettig, Klaus Fassbender, Yang Liu

Journal: FASEB J

PubMed ID: 34118085

Doi: 10.1096/fj.202100017R

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Enzymatic activation of pyruvate kinase increases cytosolic oxaloacetate to inhibit the Warburg effect

Authors: Elizabeth K Wiese, Sadae Hitosugi, Sharon T Loa, Annapoorna Sreedhar, Lindsey G Andres-Beck, Kiran Kurmi, Yuan-Ping Pang, Larry M Karnitz, Wilson I Gonsalves, Taro Hitosugi

Journal: Nat Metab

PubMed ID: 34226744

Doi: 10.1038/s42255-021-00424-5

Products & Services: Mammalian Expression

Current diagnostic approaches to detect two important betacoronaviruses: Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Authors: Zhi Xiong Chong, Winnie Pui Pui Liew, Hui Kian Ong, Chean Yeah Yong, Chong Seng Shit, Wan Yong Ho, Stephanie Y L Ng, Swee Keong Yeap

Journal: Pathol Res Pract

PubMed ID: 34333398

Doi: 10.1016/j.prp.2021.153565

Stress-primed secretory autophagy promotes extracellular BDNF maturation by enhancing MMP9 secretion

Authors: Silvia Martinelli, Elmira A Anderzhanova, Thomas Bajaj, Svenja Wiechmann, Frederik Dethloff, Katja Weckmann, Daniel E Heinz, Tim Ebert, Jakob Hartmann, Thomas M Geiger, Michael Döngi, Kathrin Hafner, Max L Pöhlmann, Lee Jollans, Alexandra Philipsen, Susanne V Schmidt, Ulrike Schmidt, Giuseppina Maccarrone, Valentin Stein, Felix Hausch, Christoph W Turck, Mathias V Schmidt, Anne-Kathrin Gellner, Bernhard Kuster, Nils C Gassen

Journal: Nat Commun

PubMed ID: 34330919

Doi: 10.1038/s41467-021-24810-5

WBP2 promotes BTRC mRNA stability to drive migration and invasion in triple-negative breast cancer via NF-κB activation

Authors: Yvonne Xinyi Lim, Hexian Lin, Tinghine Chu, Yoon Pin Lim

Journal: Mol Oncol

PubMed ID: 34197030

Doi: 10.1002/1878-0261.13048

Products & Services: Recombinant Proteins

Genome-wide identification of heat shock transcription factors and potential role in regulation of antioxidant response under hot water and glycine betaine treatments in cold-stored peaches

Authors: Li Wang, Yuanyuan Hou, Yi Wang, Shunqing Hu, Yonghua Zheng, Peng Jin

Journal: J Sci Food Agric

PubMed ID: 34146341

Doi: 10.1002/jsfa.11392

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The key role of gut-liver axis in pyrrolizidine alkaloid-induced hepatotoxicity and enterotoxicity

Authors: Yisheng He, Jiang Ma, Xiaoyu Fan, Liang Ding, Xinxin Ding, Qing-Yu Zhang, Ge Lin

Journal: Acta Pharm Sin B

PubMed ID: 35024309

Doi: 10.1016/j.apsb.2021.07.013

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Torpor enhances synaptic strength and restores memory performance in a mouse model of Alzheimer's disease

Authors: Christina F de Veij Mestdagh, Jaap A Timmerman, Frank Koopmans, Iryna Paliukhovich, Suzanne S M Miedema, Maaike Goris, Rolinka J van der Loo, Guido Krenning, Ka Wan Li, Huibert D Mansvelder, August B Smit, Robert H Henning, Ronald E van Kesteren

Journal: Sci Rep

PubMed ID: 34326412

Doi: 10.1038/s41598-021-94992-x

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Human cell transformation by combined lineage conversion and oncogene expression

Authors: Biswajyoti Sahu, Päivi Pihlajamaa, Kaiyang Zhang, Kimmo Palin, Saija Ahonen, Alejandra Cervera, Ari Ristimäki, Lauri A Aaltonen, Sampsa Hautaniemi, Jussi Taipale

Journal: Oncogene

PubMed ID: 34302118

Doi: 10.1038/s41388-021-01940-0

Products & Services: DNA Sequencing

Tumor-promoting function of PIMREG in glioma by activating the β-catenin pathway

Authors: Dekang Wang, Aili Hu, Hao Peng, Dongbo Li, Li Zhang

Journal: 3 Biotech

PubMed ID: 34458056

Doi: 10.1007/s13205-021-02922-5

Products & Services: DNA Sequencing

A 5'-tRNA halve, tiRNA-Gly promotes cell proliferation and migration via binding to RBM17 and inducing alternative splicing in papillary thyroid cancer

Authors: Litao Han, Hejing Lai, Yichen Yang, Jiaqian Hu, Zhe Li, Ben Ma, Weibo Xu, Wanlin Liu, Wenjun Wei, Duanshu Li, Yu Wang, Qiwei Zhai, Qinghai Ji, Tian Liao

Journal: J Exp Clin Cancer Res

PubMed ID: 34225773

Doi: 10.1186/s13046-021-02024-3

Products & Services: DNA Sequencing

PDIA6 promotes pancreatic cancer progression and immune escape through CSN5-mediated deubiquitination of β-catenin and PD-L1

Authors: Yihui Ma, Peiyi Xia, Zhengyang Wang, Jingjing Xu, Lan Zhang, Yanan Jiang

Journal: Neoplasia

PubMed ID: 34325342

Doi: 10.1016/j.neo.2021.07.004

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Chemical Synthesis of the Sec-To-Cys Homologue of Human Selenoprotein F and Elucidation of Its Disulfide-pairing Mode

Authors: Peisi Liao, Chunmao He

Journal: Front Chem

PubMed ID: 34395389

Doi: 10.3389/fchem.2021.735149

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Transcriptional activation of ENPP2 by FoxO4 protects cardiomyocytes from doxorubicin‑induced toxicity

Authors: Ling He, Yuting Yang, Juan Chen, Pengtao Zou, Juxiang Li

Journal: Mol Med Rep

PubMed ID: 34296293

Doi: 10.3892/mmr.2021.12307

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Functional Expression of a Mo-Cu-Dependent Carbon Monoxide Dehydrogenase (CODH) and Its Use as a Dissolved CO Bio-microsensor

Authors: Stacy Simai Reginald, Michael Etzerodt, Deby Fapyane, In Seop Chang

Journal: ACS Sens

PubMed ID: 34253013

Doi: 10.1021/acssensors.1c01243

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Hsa_circ_0008360 sponges miR-186-5p to target CCND2 to modulate high glucose-induced vascular endothelial dysfunction

Authors: Qian-Qian Zhu, Xi-Bin Pu, Tian-Chi Chen, Chen-Yang Qiu, Zi-Heng Wu, Lu Tian, Yang-Yan He, Xiao-Hui Wang, Tao Shang, Xun Wang, Yi-Lang Xiang, Dong-Lin Li, Hong-Kun Zhang

Journal: Cell Cycle

PubMed ID: 34223793

Doi: 10.1080/15384101.2021.1918877

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The reductive carboxylation activity of heterotetrameric pyruvate synthases from hyperthermophilic archaea

Authors: Lu Xiao, Guoxia Liu, Fuyu Gong, Zhen Cai, Yin Li

Journal: Biochem Biophys Res Commun

PubMed ID: 34364295

Doi: 10.1016/j.bbrc.2021.07.091

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Engineering a new vaccine platform for heterologous antigen delivery in live-attenuated

Authors: Esther Broset, Juan Calvet Seral, Carmen Arnal, Santiago Uranga, Alex I Kanno, Luciana C C Leite, Carlos Martín, Jesús Gonzalo-Asensio

Journal: Comput Struct Biotechnol J

PubMed ID: 34429847

Doi: 10.1016/j.csbj.2021.07.035

Products & Services: Codon Optimization

Cation and Anion Channelrhodopsins: Sequence Motifs and Taxonomic Distribution

Authors: Elena G Govorunova, Oleg A Sineshchekov, Hai Li, Yumei Wang, Leonid S Brown, Alyssa Palmateer, Michael Melkonian, Shifeng Cheng, Eric Carpenter, Jordan Patterson, Gane K-S Wong, John L Spudich

Journal: MBio

PubMed ID: 34281394

Doi: 10.1128/mBio.01656-21

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CD8 T cells specific for conserved coronavirus epitopes correlate with milder disease in COVID-19 patients

Authors: Vamsee Mallajosyula, Conner Ganjavi, Saborni Chakraborty, Alana M McSween, Ana Jimena Pavlovitch-Bedzyk, Julie Wilhelmy, Allison Nau, Monali Manohar, Kari C Nadeau, Mark M Davis

Journal: Sci Immunol

PubMed ID: 34210785

Doi: 10.1126/sciimmunol.abg5669

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SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape

Authors: Tyler N Starr, Nadine Czudnochowski, Zhuoming Liu, Fabrizia Zatta, Young-Jun Park, Amin Addetia, Dora Pinto, Martina Beltramello, Patrick Hernandez, Allison J Greaney, Roberta Marzi, William G Glass, Ivy Zhang, Adam S Dingens, John E Bowen, M Alejandra Tortorici, Alexandra C Walls, Jason A Wojcechowskyj, Anna De Marco, Laura E Rosen, Jiayi Zhou, Martin Montiel-Ruiz, Hannah Kaiser, Josh R Dillen, Heather Tucker, Jessica Bassi, Chiara Silacci-Fregni, Michael P Housley, Julia di Iulio, Gloria Lombardo, Maria Agostini, Nicole Sprugasci, Katja Culap, Stefano Jaconi, Marcel Meury, Exequiel Dellota, Rana Abdelnabi, Shi-Yan Caroline Foo, Elisabetta Cameroni, Spencer Stumpf, Tristan I Croll, Jay C Nix, Colin Havenar-Daughton, Luca Piccoli, Fabio Benigni, Johan Neyts, Amalio Telenti, Florian A Lempp, Matteo S Pizzuto, John D Chodera, Christy M Hebner, Herbert W Virgin, Sean P J Whelan, David Veesler, Davide Corti, Jesse D Bloom, Gyorgy Snell

Journal: Nature

PubMed ID: 34261126

Doi: 10.1038/s41586-021-03807-6

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Advancements in structure-property correlation studies of cross-linked citric acid-based elastomers from the perspective of medical application

Authors: Filip Koper, Tomasz Swiergosz, Anna Żaba, Agata Flis, Martina Trávníčková, Lucie Bačáková, Elżbieta Pamuła, Dariusz Bogdał, Wiktor P Kasprzyk

Journal: J Mater Chem B

PubMed ID: 34323912

Doi: 10.1039/d1tb01078f

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Quantitative probing of glycosylated queuosine modifications in tRNA

Authors: Wen Zhang, Tao Pan

Journal: Methods Enzymol

PubMed ID: 34517960

Doi: 10.1016/bs.mie.2021.06.003

Products & Services: Recombinant Proteins

Development of Bacteriophage Virus-Like Particle Vaccines Displaying Conserved Epitopes of Dengue Virus Non-Structural Protein 1

Authors: Nikole L Warner, Kathryn M Frietze

Journal: Vaccines (Basel)

PubMed ID: 34358143

Doi: 10.3390/vaccines9070726

Products & Services: Peptide Synthesis

CEACAM1 Activation by CbpF-Expressing

Authors: Amjad Shhadeh, Johanna Galaski, Tamar Alon-Maimon, Jamal Fahoum, Reuven Wiener, Daniel J Slade, Ofer Mandelboim, Gilad Bachrach

Journal: Front Cell Infect Microbiol

PubMed ID: 34395310

Doi: 10.3389/fcimb.2021.699015

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Stability of SARS-CoV-2 IgG in multiple laboratory conditions and blood sample types

Authors: Jamil N Kanji, Ashley Bailey, Jayne Fenton, L Robbin Lindsay, Antonia Dibernardo, Nikki Pl Toledo, Brooks Waitt, Nadine Lecocq, Carla Osiowy, Elizabeth Giles, Jacqueline Day, William Stokes, Clayton MacDonald, LeeAnn Turnbull, Carmen Charlton

Journal: J Clin Virol

PubMed ID: 34364133

Doi: 10.1016/j.jcv.2021.104933

Products & Services: Proteins, Expression, Isolation and Analysis

Doxorubicin-Induced Fetal Mesangial Cell Death Occurs Independently of TRPC6 Channel Upregulation but Involves Mitochondrial Generation of Reactive Oxygen Species

Authors: Anberitha T Matthews, Hitesh Soni, Katherine E Robinson-Freeman, Theresa A John, Randal K Buddington, Adebowale Adebiyi

Journal: Int J Mol Sci

PubMed ID: 34299212

Doi: 10.3390/ijms22147589

Products & Services: Proteins, Expression, Isolation and Analysis

Suppression of LjBAK1-mediated immunity by SymRK promotes rhizobial infection in Lotus japonicus

Authors: Yong Feng, Ping Wu, Chao Liu, Liwei Peng, Tao Wang, Chao Wang, Qian Tan, Bixuan Li, Yajuan Ou, Hui Zhu, Songli Yuan, Renliang Huang, Gary Stacey, Zhongming Zhang, Yangrong Cao

Journal: Mol Plant

PubMed ID: 34314895

Doi: 10.1016/j.molp.2021.07.016

Products & Services: Proteins, Expression, Isolation and Analysis

Identification of neoantigen-reactive T lymphocytes in the peripheral blood of a patient with glioblastoma

Authors: Vid Leko, Gal Cafri, Rami Yossef, Biman Paria, Victoria Hill, Devikala Gurusamy, Zhili Zheng, Jared J Gartner, Todd D Prickett, Stephanie L Goff, Paul Robbins, Yong-Chen Lu, Steven A Rosenberg

Journal: J Immunother Cancer

PubMed ID: 34266885

Doi: 10.1136/jitc-2021-002882

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EZH2-induced lysine K362 methylation enhances TMPRSS2-ERG oncogenic activity in prostate cancer

Authors: Marita Zoma, Laura Curti, Dheeraj Shinde, Domenico Albino, Abhishek Mitra, Jacopo Sgrignani, Sarah N Mapelli, Giada Sandrini, Gianluca Civenni, Jessica Merulla, Giovanna Chiorino, Paolo Kunderfranco, Alessia Cacciatore, Aleksandra Kokanovic, Andrea Rinaldi, Andrea Cavalli, Carlo V Catapano, Giuseppina M Carbone

Journal: Nat Commun

PubMed ID: 34230470

Doi: 10.1038/s41467-021-24380-6

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A recombinant spike protein subunit vaccine confers protective immunity against SARS-CoV-2 infection and transmission in hamsters

Authors: Yangtao Wu, Xiaofen Huang, Lunzhi Yuan, Shaojuan Wang, Yali Zhang, Hualong Xiong, Rirong Chen, Jian Ma, Ruoyao Qi, Meifeng Nie, Jingjing Xu, Zhigang Zhang, Liqiang Chen, Min Wei, Ming Zhou, Minping Cai, Yang Shi, Liang Zhang, Huan Yu, Junping Hong, Zikang Wang, Yunda Hong, Mingxi Yue, Zonglin Li, Dabing Chen, Qingbing Zheng, Shaowei Li, Yixin Chen, Tong Cheng, Jun Zhang, Tianying Zhang, Huachen Zhu, Qinjian Zhao, Quan Yuan, Yi Guan, Ningshao Xia

Journal: Sci Transl Med

PubMed ID: 34285130

Doi: 10.1126/scitranslmed.abg1143

Products & Services: Proteins, Expression, Isolation and Analysis

Co-delivery of novel bispecific and trispecific engagers by an amplicon vector augments the therapeutic effect of an HSV-based oncolytic virotherapy

Authors: Divya Ravirala, Brandon Mistretta, Preethi H Gunaratne, Guangsheng Pei, Zhongming Zhao, Xiaoliu Zhang

Journal: J Immunother Cancer

PubMed ID: 34230110

Doi: 10.1136/jitc-2021-002454

Products & Services: Proteins, Expression, Isolation and Analysis

Alfalfa (Medicago sativa L) MsCML46 gene encoding calmodulin-like protein confers tolerance to abiotic stress in tobacco

Authors: Binghao Du, Naiyu Chen, Lili Song, Dan Wang, Hongsheng Cai, Lin Yao, Xiuting Li, Changhong Guo

Journal: Plant Cell Rep

PubMed ID: 34322731

Doi: 10.1007/s00299-021-02757-7

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A Titratable Cell Lysis-on-Demand System for Droplet-Compartmentalized Ultrahigh-Throughput Screening in Functional Metagenomics and Directed Evolution

Authors: Che Fai Alex Wong, Liisa van Vliet, Swapnil Vilas Bhujbal, Chengzhi Guo, Marit Sletmoen, Bjørn Torger Stokke, Florian Hollfelder, Rahmi Lale

Journal: ACS Synth Biol

PubMed ID: 34260196

Doi: 10.1021/acssynbio.1c00084

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Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention

Authors: Robert L Summers, Charisse Flerida A Pasaje, Joao P Pisco, Josefine Striepen, Madeline R Luth, Krittikorn Kumpornsin, Emma F Carpenter, Justin T Munro, De Lin, Andrew Plater, Avinash S Punekar, Andrew M Shepherd, Sharon M Shepherd, Manu Vanaerschot, James M Murithi, Kelly Rubiano, Aslı Akidil, Sabine Ottilie, Nimisha Mittal, A Hazel Dilmore, Madalyn Won, Rebecca E K Mandt, Kerry McGowen, Edward Owen, Chris Walpole, Manuel Llinás, Marcus C S Lee, Elizabeth A Winzeler, David A Fidock, Ian H Gilbert, Dyann F Wirth, Jacquin C Niles, Beatriz Baragaña, Amanda K Lukens

Journal: Cell Chem Biol

PubMed ID: 34348113

Doi: 10.1016/j.chembiol.2021.07.010

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Disrupts VE-Cadherin Intercellular Junctions and Traverses Endothelial Barriers Using a Cholesterol-Dependent Mechanism

Authors: Karen V Lithgow, Emily Tsao, Ethan Schovanek, Alloysius Gomez, Leigh Anne Swayne, Caroline E Cameron

Journal: Front Microbiol

PubMed ID: 34354688

Doi: 10.3389/fmicb.2021.691731

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Mitofusion is required for MOTS-c induced GLUT4 translocation

Authors: Khushwant S Bhullar, Nan Shang, Evan Kerek, Kaiyu Wu, Jianping Wu

Journal: Sci Rep

PubMed ID: 34253808

Doi: 10.1038/s41598-021-93735-2

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Overexpression of the Autoimmune Risk Variant LYP-620W Fails to Restrain Human CD4 T Cell Activation

Authors: Daniel J Perry, Leeana D Peters, Priya Saikumar Lakshmi, Lin Zhang, Zhao Han, Clive H Wasserfall, Clayton E Mathews, Mark A Atkinson, Todd M Brusko

Journal: J Immunol

PubMed ID: 34301848

Doi: 10.4049/jimmunol.2000708

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Antigenic and immunogenic evaluation of permutations of soluble hepatitis C virus envelope protein E2 and E1 antigens

Authors: Jannick Prentoe, Christoph M Janitzek, Rodrigo Velázquez-Moctezuma, Louise Goksøyr, Rebecca W Olsen, Margherita Fanalista, Elias H Augestad, Susan Thrane, Anne F Pihl, Judith M Gottwein, Adam F Sander, Jens Bukh

Journal: PLoS ONE

PubMed ID: 34329365

Doi: 10.1371/journal.pone.0255336

Products & Services: PCR Cloning and Subcloning

Recapture Lysosomal Enzyme Deficiency via Targeted Gene Disruption in the Human Near-Haploid Cell Line HAP1

Authors: Annie Brown, Jiayi Zhang, Brendan Lawler, Biao Lu

Journal: Genes (Basel)

PubMed ID: 34356092

Doi: 10.3390/genes12071076

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Heat shock protein 70 attenuates hypoxia‑induced apoptosis of pulmonary microvascular endothelial cells isolated from neonatal rats

Authors: Jing Cao, Lingjie Yang, Le Wang, Qian Zhao, Dian Wu, Mingxia Li, Yuming Mu