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Comparing the relative robustness of anion exchange and the corresponding mixed-mode chromatography on removing a weakly-bound byproduct: A case study of bispecific antibody purification
Authors: Shengwei Zhang, Ting Zhang, Yifeng Li, Yan Wan
Journal: Protein Expr Purif
PubMed ID: 34303809
Doi: 10.1016/j.pep.2021.105948
A fully defined matrix to support a pluripotent stem cell derived multi-cell-liver steatohepatitis and fibrosis model
Authors: Manoj Kumar, Burak Toprakhisar, Matthias Van Haele, Asier Antoranz, Ruben Boon, Francois Chesnais, Jonathan De Smedt, Tine Tricot, Teresa Izuel Idoype, Marco Canella, Pierre Tilliole, Jolan De Boeck, Manmohan Bajaj, Adrian Ranga, Francesca Maria Bosisio, Tania Roskams, Leo A van Grunsven, Catherine M Verfaillie
Journal: Biomaterials
PubMed ID: 34304139
Doi: 10.1016/j.biomaterials.2021.121006
A structure and function relationship study to identify the impact of the R721G mutation in the human mitochondrial lon protease
Authors: Zhou Sha, Monica M Montano, Kristy Rochon, Jason A Mears, Daniel Deredge, Patrick Wintrode, Luke Szweda, Natalie Mikita, Irene Lee
Journal: Arch Biochem Biophys
PubMed ID: 34228963
Doi: 10.1016/j.abb.2021.108983
MIR156-Targeted SPL9 Is Phosphorylated by SnRK2s and Interacts With ABI5 to Enhance ABA Responses in
Authors: Huixue Dong, Suli Yan, Yexing Jing, Ruizhen Yang, Yunwei Zhang, Yun Zhou, Yingfang Zhu, Jiaqiang Sun
Journal: Front Plant Sci
PubMed ID: 34367226
Doi: 10.3389/fpls.2021.708573
Mouse Spexin: (I) NMR Solution Structure, Docking Models for Receptor Binding, and Histological Expression at Tissue Level
Authors: Matthew K H Wong, Mulan He, Kong Hung Sze, Tao Huang, Wendy K W Ko, Zhao-Xiang Bian, Anderson O L Wong
Journal: Front Endocrinol (Lausanne)
PubMed ID: 34276561
Doi: 10.3389/fendo.2021.681646
Elimination of SARS-CoV-2 along wastewater and sludge treatment processes
Authors: Albert Serra-Compte, Susana González, Marina Arnaldos, Sabrina Berlendis, Sophie Courtois, Jean Francois Loret, Olivier Schlosser, Adela M Yáñez, Elena Soria-Soria, Mariana Fittipaldi, Gemma Saucedo, Anna Pinar-Méndez, Miquel Paraira, Belén Galofré, Juan M Lema, Sabela Balboa, Miguel Mauricio-Iglesias, Albert Bosch, Rosa M Pintó, Isabelle Bertrand, Christophe Gantzer, Carlos Montero, Xavier Litrico
Journal: Water Res
PubMed ID: 34330027
Doi: 10.1016/j.watres.2021.117435
Products & Services: Plasmid DNA Preparation   
Production of Proteins of the SARS-CoV-2 Proteome for Drug Discovery
Authors: Choon Kim, Kiran V Mahasenan, Atul Bhardwaj, Olaf Wiest, Mayland Chang, Shahriar Mobashery
Journal: ACS Omega
PubMed ID: 34337272
Doi: 10.1021/acsomega.1c02984
Products & Services: Plasmid DNA Preparation   
Structure of human Ca22 channel blocked by the painkiller ziconotide
Authors: Shuai Gao, Xia Yao, Nieng Yan
Journal: Nature
PubMed ID: 34234349
Doi: 10.1038/s41586-021-03699-6
Products & Services: Peptide Synthesis   
A novel zebrafish model for intermediate type spinal muscular atrophy demonstrates importance of Smn for maintenance of mature motor neurons
Authors: Shermaine Huiping Tay, Erna Nur Ellieyana, Yao Le, Menachem Viktor Sarusie, Clemens Grimm, Jürgen Ohmer, Ajay Mathuru, Utz Fischer, Christoph Winkler
Journal: Hum Mol Genet
PubMed ID: 34302176
Doi: 10.1093/hmg/ddab212
Products & Services: PCR Cloning and Subcloning   
Differential Packaging Into Outer Membrane Vesicles Upon Oxidative Stress Reveals a General Mechanism for Cargo Selectivity
Authors: Nichole Orench-Rivera, Meta J Kuehn
Journal: Front Microbiol
PubMed ID: 34276573
Doi: 10.3389/fmicb.2021.561863
Products & Services: PCR Cloning and Subcloning   
Antibodies Against the Clock Proteins Period and Cryptochrome Reveal the Neuronal Organization of the Circadian Clock in the Pea Aphid
Authors: Francesca Sara Colizzi, Katharina Beer, Paolo Cuti, Peter Deppisch, David Martínez Torres, Taishi Yoshii, Charlotte Helfrich-Förster
Journal: Front Physiol
PubMed ID: 34366893
Doi: 10.3389/fphys.2021.705048
Products & Services: PCR Cloning and Subcloning   
An enveloped virus-like particle vaccine expressing a stabilized prefusion form of the SARS-CoV-2 spike protein elicits highly potent immunity
Authors: Anne-Catherine Fluckiger, Barthelemy Ontsouka, Jasminka Bozic, Abebaw Diress, Tanvir Ahmed, Tamara Berthoud, Anh Tran, Diane Duque, Mingmin Liao, Michael McCluskie, Francisco Diaz-Mitoma, David E Anderson, Catalina Soare
Journal: Vaccine
PubMed ID: 34304928
Doi: 10.1016/j.vaccine.2021.07.034
Products & Services: PCR Cloning and Subcloning   
ANCHOR: A Technical Approach to Monitor Single-Copy Locus Localization in Planta
Authors: Anis Meschichi, Mathieu Ingouff, Claire Picart, Marie Mirouze, Sophie Desset, Franck Gallardo, Kerstin Bystricky, Nathalie Picault, Stefanie Rosa and Frédéric Pontvianne
Journal: Frontier in Plate Science
PubMed ID: 34295343
Doi: 10.3389/fpls.2021.677849
Products & Services: Gene Synthesis   
ANXA10 Promotes Melanoma Metastasis by Suppressing the Ubiquitination of PKD1 Mediated by E3 Ligase TRIM41
Authors: Xuerui Zhang, Zhaoqing Hu, Xinran Wang, Lin Li, Banghui Zhu, Xiaolei Lin, Jing Zhang, Zichun Hua
Journal: Cancer Letters
Doi: doi.org/10.1016/j.canlet.2021.07.033
Bemisia tabaci Vesicle-Associated Membrane Protein 2 Interacts with Begomoviruses and Plays a Role in Virus Acquisition
Authors: Yun-Yun Fan, Yu-Wei Zhong, Jing Zhao, Yao Chi, Sophie Bouvaine, Shu-Sheng Liu, Susan E Seal, Xiao-Wei Wang
Journal: Cells.
PubMed ID: 34359870
Doi: 10.3390/cells10071700
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First trimester screening with biochemical markers and ultrasound in relation to non-invasive prenatal testing (NIPT)
Authors:
Journal: J Perinat Med
PubMed ID: 34225389
Doi: 10.1515/jpm-2021-0243
Products & Services: Gene Synthesis   
miR-29a, b, and c regulate SLC5A8 expression in intestinal epithelial cells
Authors: Arivarasu N Anbazhagan, Shubha Priyamvada, Anoop Kumar, Dulari Jayawardena, Alip Borthakur, Seema Saksena, Ravinder K Gill, Waddah A Alrefai, Pradeep K Dudeja
Journal: Am J Physiol Gastrointest Liver Physiol
PubMed ID: 34231393
Doi: 10.1152/ajpgi.00148.2021
Products & Services: Custom Vector Construction   
Degradation of CCNK/CDK12 is a druggable vulnerability of colorectal cancer
Authors: Sebastian M Dieter, Christine Siegl, Paula L Codó, Mario Huerta, Anna L Ostermann-Parucha, Erik Schulz, Martina K Zowada, Sylvia Martin, Karin Laaber, Ali Nowrouzi, Mona Blatter, Sina Kreth, Frank Westermann, Axel Benner, Ulrike Uhrig, Kerstin Putzker, Joe Lewis, Andrea Haegebarth, Dominik Mumberg, Simon J Holton, Joerg Weiske, Lena-Marit Toepper, Ulrike Scheib, Gerhard Siemeister, Claudia R Ball, Bernhard Kuster, Gabriele Stoehr, Hannes Hahne, Sarah Johannes, Martin Lange, Friederike Herbst, Hanno Glimm
Journal: Cell Rep
PubMed ID: 34289372
Doi: 10.1016/j.celrep.2021.109394
Products & Services: Mammalian Expression   
Alternative 3' UTRs play a widespread role in translation-independent mRNA association with the endoplasmic reticulum
Authors: Larry C Cheng, Dinghai Zheng, Qiang Zhang, Aysegul Guvenek, Hong Cheng, Bin Tian
Journal: Cell Rep
PubMed ID: 34289366
Doi: 10.1016/j.celrep.2021.109407
Products & Services: PCR and Cloning   
Trimetazidine attenuates dexamethasone-induced muscle atrophy via inhibiting NLRP3/GSDMD pathway-mediated pyroptosis
Authors: Li Wang, Xin-Feng Jiao, Cheng Wu, Xiao-Qing Li, Hui-Xian Sun, Xi-Yu Shen, Kang-Zhen Zhang, Can Zhao, Li Liu, Man Wang, Yun-Ling Bu, Jia-Wen Li, Fan Xu, Chen-Lu Chang,Xiang Lu,corresponding author and Wei Gaocorresponding author
Journal: Journal List
PubMed ID: 34537816
Doi: 10.1038/s41420-021-00648-0
Two Inhibitors Against the 3C-Like Proteases of Swine Coronavirus and Feline Coronavirus
Authors: Mengxin Zhou, Yutong Han, Mengxia Li, Gang Ye, Guiqing Peng
Journal: Virol Sin
PubMed ID: 34228261
Doi: 10.1007/s12250-021-00415-6
Products & Services: Peptide Synthesis   
Functional Characterization of Ecdysis Triggering Hormone Receptors (AgETHR-A and AgETHR-B) in the African Malaria Mosquito,
Authors: Vikas Jindal, Yoonseong Park, Donghun Kim
Journal: Front Physiol
PubMed ID: 34295267
Doi: 10.3389/fphys.2021.702979
Products & Services: Recombinant Proteins   
Evaluation of Cell-Based and Surrogate SARS-CoV-2 Neutralization Assays
Authors: Anton M Sholukh, Andrew Fiore-Gartland, Emily S Ford, Maurine D Miner, Yixuan J Hou, Longping V Tse, Hannah Kaiser, Haiying Zhu, Joyce Lu, Bhanupriya Madarampalli, Arnold Park, Florian A Lempp, Russell St Germain, Emily L Bossard, Jia Jin Kee, Kurt Diem, Andrew B Stuart, Peter B Rupert, Chance Brock, Matthew Buerger, Margaret K Doll, April Kaur Randhawa, Leonidas Stamatatos, Roland K Strong, Colleen McLaughlin, Meei-Li Huang, Keith R Jerome, Ralph S Baric, David Montefiori, Lawrence Corey
Journal: J Clin Microbiol
PubMed ID: 34288726
Doi: 10.1128/JCM.00527-21
Products & Services: Recombinant Proteins   
Simultaneous Removal of the Freshwater Bloom-Forming Cyanobacterium and Cyanotoxin Microcystins via Combined Use of Algicidal Bacterial Filtrate and the Microcystin-Degrading Enzymatic Agent, MlrA
Authors: Suqin Wang, Siyu Yang, Jun Zuo, Chenlin Hu, Lirong Song, Nanqin Gan, Peng Chen
Journal: Microorganisms
PubMed ID: 34442673
Doi: 10.3390/microorganisms9081594
Mouse Spexin: (II) Functional Role as a Satiety Factor inhibiting Food Intake by Regulatory Actions Within the Hypothalamus
Authors: Matthew K H Wong, Yuan Chen, Mulan He, Chengyuan Lin, Zhaoxiang Bian, Anderson O L Wong
Journal: Front Endocrinol (Lausanne)
PubMed ID: 34276562
Doi: 10.3389/fendo.2021.681647
Grape Seed Proanthocyanidin Extract Moderated Retinal Pigment Epithelium Cellular Senescence Through NAMPT/SIRT1/NLRP3 Pathway
Authors: Wencui Wan, Wei Zhu, Yan Wu, Yang Long, Hongzhuo Liu, Weiwei Wan, Guangming Wan, Jing Yu
Journal: J Inflamm Res
PubMed ID: 34285539
Doi: 10.2147/JIR.S306456
Products & Services: PCR and Cloning   
GhKWL1 Upregulates but Its Function Is Impaired by Binding with VdISC1, a Pathogenic Effector of
Authors: Yang Chen, Mi Zhang, Lei Wang, Xiaohan Yu, Xianbi Li, Dan Jin, Jianyan Zeng, Hui Ren, Fanlong Wang, Shuiqing Song, Xingying Yan, Juan Zhao, Yan Pei
Journal: Int J Mol Sci
PubMed ID: 34298948
Doi: 10.3390/ijms22147328
Products & Services: Protein Tools   
The DUB family in Populus: identification, characterization, evolution and expression patterns
Authors: Wenqing Zheng, Liang Du
Journal: BMC Genomics
PubMed ID: 34266381
Doi: 10.1186/s12864-021-07844-3
Products & Services: Protein Tools   
The endopeptidase of the maize-affecting Marafivirus type member maize rayado fino virus doubles as a deubiquitinase
Authors: Ankoor Patel, Jessica A M McBride, Brian L Mark
Journal: J Biol Chem
PubMed ID: 34265303
Doi: 10.1016/j.jbc.2021.100957
Products & Services: Custom Vector Construction   
Comprehensive Characterization of Universal Stress Proteins in Rice ( L) With Insight Into Their Stress-Specific Transcriptional Modulation
Authors: Shatil Arabia, Asif Ahmed Sami, Saima Akhter, Rakha Hari Sarker, Tahmina Islam
Journal: Front Plant Sci
PubMed ID: 34394169
Doi: 10.3389/fpls.2021.712607
Products & Services: Protein Tools   
WBP2 promotes BTRC mRNA stability to drive migration and invasion in triple-negative breast cancer via NF-κB activation
Authors: Yvonne Xinyi Lim, Hexian Lin, Tinghine Chu, Yoon Pin Lim
Journal: Mol Oncol
PubMed ID: 34197030
Doi: 10.1002/1878-0261.13048
Products & Services: Recombinant Proteins   
Development of a Platform for Noncovalent Coupling of Full Antigens to Tobacco Etch Virus-Like Particles by Means of Coiled-Coil Oligomerization Motifs
Authors: Lorena Zapata-Cuellar, Jorge Gaona-Bernal, Carlos Alberto Manuel-Cabrera, Moisés Martínez-Velázquez, Carla Sánchez-Hernández, Darwin Elizondo-Quiroga, Tanya Amanda Camacho-Villegas, Abel Gutiérrez-Ortega
Journal: Molecules
PubMed ID: 34361589
Doi: 10.3390/molecules26154436
Products & Services: Bacterial Expression   
Melioidosis Patient Survival Correlates With Strong IFN-γ Secreting T Cell Responses Against Hcp1 and TssM
Authors: Sineenart Sengyee, Atchara Yarasai, Rachan Janon, Chumpol Morakot, Orawan Ottiwet, Lindsey K Schmidt, T Eoin West, Mary N Burtnick, Narisara Chantratita, Paul J Brett
Journal: Front Immunol
PubMed ID: 34394091
Doi: 10.3389/fimmu.2021.698303
Products & Services: GenParts™ DNA Fragments   
CCR2 Regulates Vaccine-Induced Mucosal T-Cell Memory to Influenza A Virus
Authors: Woojong Lee, Brock Kingstad-Bakke, Ross M Kedl, Yoshihiro Kawaoka, M Suresh
Journal: J Virol
PubMed ID: 33952647
Doi: 10.1128/JVI.00530-21
Products & Services: Mammalian Expression   
In Silico Target Prediction of Overexpressed microRNAs from LPS-Challenged Zebrafish () Treated with the Novel Anti-Inflammatory Peptide P
Authors: Geonildo R Disner, Maria A P Falcão, Carla Lima, Monica Lopes-Ferreira
Journal: Int J Mol Sci
PubMed ID: 34281170
Doi: 10.3390/ijms22137117
Candida albicans and Candida glabrata triosephosphate isomerase - a moonlighting protein that can be exposed on the candidal cell surface and bind to human extracellular matrix proteins
Authors: Dorota Satala, Grzegorz Satala, Marcin Zawrotniak, Andrzej Kozik
Journal: BMC Microbiol
PubMed ID: 34210257
Doi: 10.1186/s12866-021-02235-w
Products & Services: GenParts™ DNA Fragments   
African Swine Fever Virus CD2v Protein Induces β-Interferon Expression and Apoptosis in Swine Peripheral Blood Mononuclear Cells
Authors: Sabal Chaulagain, Gustavo A Delhon, Sushil Khatiwada, Daniel L Rock
Journal: Viruses
PubMed ID: 34452346
Doi: 10.3390/v13081480
Products & Services: Gene Synthesis   
Species-specific gamete recognition initiates fusion-driving trimer formation by conserved fusogen HAP2
Authors: Jun Zhang, Jennifer F Pinello, Ignacio Fernández, Eduard Baquero, Juliette Fedry, Félix A Rey, William J Snell
Journal: Nat Commun
PubMed ID: 34282138
Doi: 10.1038/s41467-021-24613-8
Products & Services: Gene Synthesis   
Hinge Binder Scaffold Hopping Identifies Potent Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2) Inhibitor Chemotypes
Authors: Benjamin J Eduful, Sean N O'Byrne, Louisa Temme, Christopher R M Asquith, Yi Liang, Alfredo Picado, Joseph R Pilotte, Mohammad Anwar Hossain, Carrow I Wells, William J Zuercher, Carolina M C Catta-Preta, Priscila Zonzini Ramos, André de S Santiago, Rafael M Couñago, Christopher G Langendorf, Kévin Nay, Jonathan S Oakhill, Thomas L Pulliam, Chenchu Lin, Dominik Awad, Timothy M Willson, Daniel E Frigo, John W Scott, David H Drewry
Journal: J Med Chem
PubMed ID: 34264658
Doi: 10.1021/acs.jmedchem.0c02274
Products & Services: Stable Cell Lines   
Heparin promotes fibrillation of most phenol-soluble modulin virulence peptides from Staphylococcus aureus
Authors: Zahra Najarzadeh, Masihuz Zaman, Vita Sereikaite, Kristian Strømgaard, Maria Andreasen, Daniel E Otzen
Journal: J Biol Chem
PubMed ID: 34270957
Doi: 10.1016/j.jbc.2021.100953
Products & Services: Catalog Peptides   
Folding of cohesin's coiled coil is important for Scc2/4-induced association with chromosomes
Authors: Naomi J Petela, Andres Gonzalez Llamazares, Sarah Dixon, Bin Hu, Byung-Gil Lee, Jean Metson, Heekyo Seo, Antonio Ferrer-Harding, Menelaos Voulgaris, Thomas Gligoris, James Collier, Byung-Ha Oh, Jan Löwe, Kim A Nasmyth
Journal: Elife
PubMed ID: 34259632
Doi: 10.7554/eLife.67268
Products & Services: Catalog Antibody   
spp Omp25 Promotes Proteasome-Mediated cGAS Degradation to Attenuate IFN-β Production
Authors: Ruizhen Li, Wenli Liu, Xiangrui Yin, Fangfang Zheng, Zhenyu Wang, Xingchen Wu, Xiaohua Zhang, Qian Du, Yong Huang, Dewen Tong
Journal: Front Microbiol
PubMed ID: 34394047
Doi: 10.3389/fmicb.2021.702881
Products & Services: Catalog Antibody   
A Covalent Calmodulin Inhibitor as a Tool to Study Cellular Mechanisms of K-Ras-Driven Stemness
Authors: Sunday Okutachi, Ganesh Babu Manoharan, Alexandros Kiriazis, Christina Laurini, Marie Catillon, Frank McCormick, Jari Yli-Kauhaluoma, Daniel Abankwa
Journal: Front Cell Dev Biol
PubMed ID: 34307350
Doi: 10.3389/fcell.2021.665673
Products & Services: Catalog Peptides   
Measuring nonhomologous end-joining, homologous recombination and alternative end-joining simultaneously at an endogenous locus in any transfectable human cell
Authors: Suleman S Hussain, Rahul Majumdar, Grace M Moore, Himanshi Narang, Erika S Buechelmaier, Maximilian J Bazil, Pavithran T Ravindran, Jonathan E Leeman, Yi Li, Manisha Jalan, Kyrie S Anderson, Andrea Farina, Rekha Soni, Neeman Mohibullah, Edin Hamzic, Xiaoqing Rong-Mullins, Christopher Sifuentes, Rama R Damerla, Agnes Viale, Simon N Powell, Daniel S Higginson
Journal: Nucleic Acids Res
PubMed ID: 33877327
Doi: 10.1093/nar/gkab262
Products & Services: Plasmid DNA Preparation   
P38α-MAPK phosphorylates Snapin and reduces Snapin-mediated BACE1 transportation in APP-transgenic mice
Authors: Laura Schnöder, Inge Tomic, Laura Schwindt, Dominic Helm, Mandy Rettel, Walter Schulz-Schaeffer, Elmar Krause, Jens Rettig, Klaus Fassbender, Yang Liu
Journal: FASEB J
PubMed ID: 34118085
Doi: 10.1096/fj.202100017R
Products & Services: Custom Vector Construction   
Enzymatic activation of pyruvate kinase increases cytosolic oxaloacetate to inhibit the Warburg effect
Authors: Elizabeth K Wiese, Sadae Hitosugi, Sharon T Loa, Annapoorna Sreedhar, Lindsey G Andres-Beck, Kiran Kurmi, Yuan-Ping Pang, Larry M Karnitz, Wilson I Gonsalves, Taro Hitosugi
Journal: Nat Metab
PubMed ID: 34226744
Doi: 10.1038/s42255-021-00424-5
Products & Services: Mammalian Expression   
Current diagnostic approaches to detect two important betacoronaviruses: Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Authors: Zhi Xiong Chong, Winnie Pui Pui Liew, Hui Kian Ong, Chean Yeah Yong, Chong Seng Shit, Wan Yong Ho, Stephanie Y L Ng, Swee Keong Yeap
Journal: Pathol Res Pract
PubMed ID: 34333398
Doi: 10.1016/j.prp.2021.153565
Stress-primed secretory autophagy promotes extracellular BDNF maturation by enhancing MMP9 secretion
Authors: Silvia Martinelli, Elmira A Anderzhanova, Thomas Bajaj, Svenja Wiechmann, Frederik Dethloff, Katja Weckmann, Daniel E Heinz, Tim Ebert, Jakob Hartmann, Thomas M Geiger, Michael Döngi, Kathrin Hafner, Max L Pöhlmann, Lee Jollans, Alexandra Philipsen, Susanne V Schmidt, Ulrike Schmidt, Giuseppina Maccarrone, Valentin Stein, Felix Hausch, Christoph W Turck, Mathias V Schmidt, Anne-Kathrin Gellner, Bernhard Kuster, Nils C Gassen
Journal: Nat Commun
PubMed ID: 34330919
Doi: 10.1038/s41467-021-24810-5
Differential Serotonin Uptake Mechanisms at the Human Maternal-Fetal Interface
Authors: Petra Baković, Maja Kesić, Maja Perić, Ivona Bečeheli, Marina Horvatiček, Meekha George, Lipa Čičin-Šain, Gernot Desoye, Christian Wadsack, Ute Panzenboeck, Jasminka Štefulj
Journal: Int J Mol Sci
PubMed ID: 34360573
Doi: 10.3390/ijms22157807
Products & Services: ORF cDNA Clones/MolecularCloud   
Investigating the conformational dynamics of SARS-CoV-2 NSP6 protein with emphasis on non-transmembrane 91-112 & 231-290 regions
Authors: Amit Kumar, ProfilePrateek Kumar, Kumar Udit Saumya, ProfileRajanish Giri
Journal: biorxiv
Doi: doi.org/10.1101/2021.07.06.451329
Products & Services: Peptide Synthesis   

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