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Asymmetric Pericentrosomal CD133 Endosomes Induce the Unequal Autophagic Activity During Cytokinesis in CD133-Positive Human Neuroblastoma Cells

Authors: Hideki Izumi, Yuanyuan Li, Michio Yasunami, Seiji Sato, Takao Mae, Yasuhiko Kaneko, Akira Nakagawara

Journal: Stem Cells

PubMed ID: 35284915

Doi: 10.1093/stmcls/sxac007

Products & Services: DNA Sequencing

Insect Cells for High-Yield Production of SARS-CoV-2 Spike Protein: Building a Virosome-Based COVID-19 Vaccine Candidate

Authors: Bárbara Fernandes, Rute Castro, Farien Bhoelan, Denzel Bemelman, Ricardo A Gomes, Júlia Costa, Patrícia Gomes-Alves, Toon Stegmann, Mario Amacker, Paula M Alves, Sylvain Fleury, António Roldão

Journal: Pharmaceutics

PubMed ID: 35456687

Doi: 10.3390/pharmaceutics14040854

Products & Services: Plasmid DNA Preparation

G-protein biased signaling agonists of Dopamine D3 receptor promote distinct activation patterns of ERK1/2

Authors: Wei Xu, Frank Bearoff, Sandhya Kortagere

Journal: Pharmacol Res

PubMed ID: 35429668

Doi: 10.1016/j.phrs.2022.106223

Products & Services: Protein and Antibody Isolation

CLEVER assay: A visual and rapid RNA extraction-free detection of SARS-CoV-2 based on CRISPR-Cas integrated RT-LAMP technology

Authors: Akansha Bhatt, Zeeshan Fatima, Munindra Ruwali, Chitra Seetharam Misra, Shyam Sunder Rangu, Devashish Rath, Ashok Rattan, Saif Hameed

Journal: J Appl Microbiol

PubMed ID: 35396760

Doi: 10.1111/jam.15571

Products & Services: Plasmid DNA Preparation

Functional and Structural Insights into Human PPARα/δ/γ Subtype Selectivity of Bezafibrate, Fenofibric Acid, and Pemafibrate

Authors: Akihiro Honda, Shotaro Kamata, Makoto Akahane, Yui Machida, Kie Uchii, Yui Shiiyama, Yuki Habu, Saeka Miyawaki, Chihiro Kaneko, Takuji Oyama, Isao Ishii

Journal: Int J Mol Sci

PubMed ID: 35563117

Doi: 10.3390/ijms23094726

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CXCR7 Agonist TC14012 Improves Angiogenic Function of Endothelial Progenitor Cells via Activating Akt/eNOS Pathway and Promotes Ischemic Angiogenesis in Diabetic Limb Ischemia

Authors: Kai Wang, Shiyue Sun, Guigui Zhang, Zixian Lu, Hui Chen, Xia Fan, Chunjie Gu, Xiaohong Pan, Qian Lin, Oscar Chen, Lu Cai, Xiaozhen Dai, Xiao Wang, Chaosheng Lu, Xiaoqing Yan, Yi Tan

Journal: Cardiovasc Drugs Ther

PubMed ID: 35471717

Doi: 10.1007/s10557-022-07337-9

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Mechanism of sensitivity modulation in the calcium-sensing receptor via electrostatic tuning

Authors: Michael R Schamber , Reza Vafabakhsh

Journal: Nat Commun

PubMed ID: 35459864

Doi: 10.1038/s41467-022-29897-y

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Coenzyme B 12 -dependent and independent photoregulation of carotenogenesis across Myxococcales

Authors: Ricardo Pérez-Castaño , Eva Bastida-Martínez , Jesús Fernández-Zapata , María Del Carmen Polanco , María Luisa Galbis-Martínez , Antonio A Iniesta , Marta Fontes , S Padmanabhan , Montserrat Elías-Arnanz

Journal: Environ Microbiol

PubMed ID: 35005822

Doi: 10.1111/1462-2920.15895

Products & Services: Gene Synthesis

Characterization of Genetic Variants of Uncertain Significance for the Gene in Patients With Adult Hypophosphatasia

Authors: Raquel Sanabria-de la Torre, Luis Martínez-Heredia, Sheila González-Salvatierra, Francisco Andújar-Vera, Iván Iglesias-Baena, Juan Miguel Villa-Suárez, Victoria Contreras-Bolívar, Mario Corbacho-Soto, Gonzalo Martínez-Navajas, Pedro J Real, Cristina García-Fontana, Manuel Muñoz-Torres, Beatriz García-Fontana

Journal: Front Endocrinol (Lausanne)

PubMed ID: 35498405

Doi: 10.3389/fendo.2022.863940

Products & Services: Mutant Libraries

Blocking TGF- Expression Attenuates Tumor Growth in Lung Cancers, Potentially Mediated by Skewing Development of Neutrophils

Authors: Yifei Fang, Xiyao Li, Yuxuan Jiang, Zhihan Ge

Journal: J Oncol

PubMed ID: 35498537

Doi: 10.1155/2022/3447185

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Identification of Potential Peptide Marker(s) for Evaluating Pork Meat Freshness via Mass Spectrometry-Based Peptidomics during Storage under Different Temperatures

Authors: Zhenqian Wei, Chen Dai, Anthony P Bassey, Changbo Tang, Yu Han, Chong Wang, Guanghong Zhou

Journal: Foods

PubMed ID: 35454731

Doi: 10.3390/foods11081144

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Exploration of Pyrrolysyl-tRNA Synthetase Activity in Yeast

Authors: Jessica T Stieglitz, Priyanka Lahiri, Matthew I Stout, James A Van Deventer

Journal: ACS Synth Biol

PubMed ID: 35417129

Doi: 10.1021/acssynbio.2c00001

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β-arrestin2 mediates the hippocampal dopaminergic system in autistic mouse through the ERK signaling pathway

Authors: Yu Zhou, Yamei Liu, Qingyu Peng, Feng Li, Fuxue Chen

Journal: Behav Brain Res

PubMed ID: 35398487

Doi: 10.1016/j.bbr.2022.113888

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Identification of Single-Molecule Catecholamine Enantiomers Using a Programmable Nanopore

Authors: Wendong Jia, Chengzhen Hu, Yuqin Wang, Yao Liu, Liying Wang, Shanyu Zhang, Qiang Zhu, Yuming Gu, Panke Zhang, Jing Ma, Hong-Yuan Chen, Shuo Huang

Journal: ACS Nano

PubMed ID: 35394745

Doi: 10.1021/acsnano.2c01017

Products & Services: Gene Synthesis

A Nanopore Based Molnupiravir Sensor

Authors: Wendong Jia , Chengzhen Hu , Yuqin Wang , Panke Zhang , Hong-Yuan Chen , Shuo Huang

Journal: ACS Sens

PubMed ID: 35427117

Doi: 10.1021/acssensors.2c00447

Products & Services: Plasmid DNA Preparation

USP14-regulated allostery of the human proteasome by time-resolved cryo-EM

Authors: Shuwen Zhang , Shitao Zou , Deyao Yin , Lihong Zhao , Daniel Finley , Zhaolong Wu , Youdong Mao

Journal: Nature

PubMed ID: 35477760

Doi: 10.1038/s41586-022-04671-8

Products & Services: Gene Synthesis

CRISPR-free base editors with enhanced activity and expanded targeting scope in mitochondrial and nuclear DNA

Authors: Beverly Y Mok, Anna V Kotrys, Aditya Raguram, Tony P Huang, Vamsi K Mootha, David R Liu

Journal: Nat Biotechnol

PubMed ID: 35379961

Doi: 10.1038/s41587-022-01256-8

Products & Services: Mammalian Expression

PPARγ phase separates with RXRα at PPREs to regulate target gene expression

Authors: Zhean Li, Lingling Luo, Wenxia Yu, Ping Li, Danfeng Ou, Jia Liu, Hanhui Ma, Qinhu Sun, Aibin Liang, Cheng Huang, Tian Chi, Xingxu Huang, Yu Zhang

Journal: Cell Discov

PubMed ID: 35473936

Doi: 10.1038/s41421-022-00388-0

Products & Services: Gene Fragments

A phenotypic signature that identifies neoantigen-reactive T cells in fresh human lung cancers

Authors: Ken-Ichi Hanada, Chihao Zhao, Raul Gil-Hoyos, Jared J Gartner, Christopher Chow-Parmer, Frank J Lowery, Sri Krishna, Todd D Prickett, Scott Kivitz, Maria R Parkhurst, Nathan Wong, Zachary Rae, Michael C Kelly, Stephanie L Goff, Paul F Robbins, Steven A Rosenberg, James C Yang

Journal: Cancer Cell

PubMed ID: 35452604

Doi: 10.1016/j.ccell.2022.03.012

Products & Services: Neoantigen Peptide Service

OCC-1D regulates Wnt signaling pathway: potential role of long noncoding RNA in colorectal cancer

Authors: Fatemeh Yousefi, Hadi Najafi, Mehrdad Behmanesh, Bahram M Soltani

Journal: Mol Biol Rep

PubMed ID: 35397713

Doi: 10.1007/s11033-021-07110-5

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Ultrasensitive CRISPR/Cas12a-Driven SERS Biosensor for On-Site Nucleic Acid Detection and Its Application to Milk Authenticity Testing

Authors: Ruiyuan Pan, Jianghua Liu, Panxue Wang, Di Wu, Jian Chen, Yongning Wu, Guoliang Li

Journal: J Agric Food Chem

PubMed ID: 35380812

Doi: 10.1021/acs.jafc.1c08262

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Small molecules targeting the NADH-binding pocket of VDAC modulate mitochondrial metabolism in hepatocarcinoma cells

Authors: Kareem A Heslop, Pieter Burger, Christiana Kappler, Ashish K Solanki, Monika Gooz, Yuri K Peterson, Catherine Mills, Thomas Benton, Stephen A Duncan, Patrick M Woster, Eduardo N Maldonado

Journal: Biomed Pharmacother

PubMed ID: 35447542

Doi: 10.1016/j.biopha.2022.112928

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The development of a candidate of desensitization vaccines against Der f 2 nearly without IgE-binding activity

Authors: Xiao-Jing Ling, Chen Pan, Ling-Xiao Tan, Ying Zhu, Yu-Xing Yang, Xiao-Fei Zeng, Jin-Lyu Sun, Ji-Fu Wei, Chen Lu

Journal: Immunobiology

PubMed ID: 35580444

Doi: 10.1016/j.imbio.2022.152217

Products & Services: Protein and Antibody Isolation

Mucus concentration-dependent biophysical abnormalities unify submucosal gland and superficial airway dysfunction in cystic fibrosis

Authors: Takafumi Kato, Giorgia Radicioni, Micah J Papanikolas, Georgi V Stoychev, Matthew R Markovetz, Kazuhiro Aoki, Melody Porterfield, Kenichi Okuda, Selene M Barbosa Cardenas, Rodney C Gilmore, Cameron B Morrison, Camille Ehre, Kimberlie A Burns, Kristen K White, Tara A Brennan, Henry P Goodell, Holly Thacker, Henry T Loznev, Lawrence J Forsberg, Takahide Nagase, Michael Rubinstein, Scott H Randell, Michael Tiemeyer, David B Hill, Mehmet Kesimer, Wanda K O'Neal, Stephen T Ballard, Ronit Freeman, Brian Button, Richard C Boucher

Journal: Sci Adv

PubMed ID: 35363522

Doi: 10.1126/sciadv.abm9718

Products & Services: Plasmid DNA Preparation

First computational design using lambda-superstrings and in vivo validation of SARS-CoV-2 vaccine

Authors: Luis Martínez, Iker Malaina, David Salcines-Cuevas, Héctor Terán-Navarro, Andrea Zeoli, Santos Alonso, Ildefonso M De la Fuente, Elena Gonzalez-Lopez, J Gonzalo Ocejo-Vinyals, Mónica Gozalo-Margüello, Jorge Calvo-Montes, Carmen Alvarez-Dominguez

Journal: Sci Rep

PubMed ID: 35440789

Doi: 10.1038/s41598-022-09615-w

The crystal structure of iC3b-CR3 αI reveals a modular recognition of the main opsonin iC3b by the CR3 integrin receptor

Authors: Francisco J Fernández, Jorge Santos-López, Rubén Martínez-Barricarte, Javier Querol-García, Héctor Martín-Merinero, Sergio Navas-Yuste, Martin Savko, William E Shepard, Santiago Rodríguez de Córdoba, M Cristina Vega

Journal: Nat Commun

PubMed ID: 35413960

Doi: 10.1038/s41467-022-29580-2

Products & Services: Plasmid DNA Preparation

Efficient multinucleotide deletions using deaminase-Cas9 fusions in human cells

Authors: Siyu Chen, Zhiquan Liu, Hao Yu, Liangxue Lai, Zhanjun Li

Journal: J Genet Genomics

PubMed ID: 35421582

Doi: 10.1016/j.jgg.2022.03.007

Products & Services: Mutagenesis Services

TXNDC9 knockdown inhibits lung adenocarcinoma progression by targeting YWHAG

Authors: Jing Wang, Xiaotao Pan, Jie Li, Jin Zhao

Journal: Mol Med Rep

PubMed ID: 35485284

Doi: 10.3892/mmr.2022.12719

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Molecular spikes: a gold standard for single-cell RNA counting

Authors: Christoph Ziegenhain, Gert-Jan Hendriks, Michael Hagemann-Jensen, Rickard Sandberg

Journal: Nat Methods

PubMed ID: 35468967

Doi: 10.1038/s41592-022-01446-x

Products & Services: Gene Synthesis

NADH oxidase of Mycoplasma hyopneumoniae functions as a potential mediator of virulence

Authors: Fei Hao, Xing Xie, Zhixin Feng, Rong Chen, Yanna Wei, Jin Liu, Qiyan Xiong, Guoqing Shao, Johnson Lin

Journal: BMC Vet Res

PubMed ID: 35366872

Doi: 10.1186/s12917-022-03230-7

Products & Services: Bacterial Expression

Transcriptome analysis reveals the regulatory mechanism by which suppresses adventitious shoot formation in apple

Authors: Jiangping Mao, Doudou Ma, Chundong Niu, Xiaolong Ma, Ke Li, Muhammad Mobeen Tahir, Shiyue Chen, Xiuxiu Liu, Dong Zhang

Journal: Hortic Res

PubMed ID: 35669707

Doi: 10.1093/hr/uhac080

Products & Services: Polyclonal Antibody Services

Glycoside hydrolase from the GH76 family indicates that marine Salegentibacter sp Hel_I_6 consumes alpha-mannan from fungi

Authors: Vipul Solanki, Karen Krüger, Conor J Crawford, Alonso Pardo-Vargas, José Danglad-Flores, Kim Le Mai Hoang, Leeann Klassen, D Wade Abbott, Peter H Seeberger, Rudolf I Amann, Hanno Teeling, Jan-Hendrik Hehemann

Journal: ISME J

PubMed ID: 35414716

Doi: 10.1038/s41396-022-01223-w

Products & Services: Plasmid DNA Preparation

Histone acetyltransferase GCN5-mediated lysine acetylation modulates salt stress aadaption of Trichoderma

Authors: Zhe Li, Hao Zhang, Chunjing Cai, Zhong Lin, Zhen Zhen, Jie Chu, Kai Guo

Journal: Appl Microbiol Biotechnol

PubMed ID: 35376971

Doi: 10.1007/s00253-022-11897-z

Products & Services: Polyclonal Antibody Services

Deletion and tandem duplications of biosynthetic genes drive the diversity of triterpenoids in Aralia elata

Authors: Yu Wang, He Zhang, Hyok Chol Ri, Zeyu An, Xin Wang, Jia-Nan Zhou, Dongran Zheng, Hao Wu, Pengchao Wang, Jianfei Yang, Ding-Kun Liu, Diyang Zhang, Wen-Chieh Tsai, Zheyong Xue, Zhichao Xu, Peng Zhang, Zhong-Jian Liu, Hailong Shen, Yuhua Li

Journal: Nat Commun

PubMed ID: 35468919

Doi: 10.1038/s41467-022-29908-y

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Structural definition of a pan-sarbecovirus neutralizing epitope on the spike S2 subunit

Authors: Nicholas K Hurlburt, Leah J Homad, Irika Sinha, Madeleine F Jennewein, Anna J MacCamy, Yu-Hsin Wan, Jim Boonyaratanakornkit, Anton M Sholukh, Abigail M Jackson, Panpan Zhou, Dennis R Burton, Raiees Andrabi, Gabriel Ozorowski, Andrew B Ward, Leonidas Stamatatos, Marie Pancera, Andrew T McGuire

Journal: Commun Biol

PubMed ID: 35411021

Doi: 10.1038/s42003-022-03262-7

Products & Services: Recombinant Proteins

Dynamic of anti-spike receptor binding domain (RBD) levels and short-term adverse events following a heterologous booster dose of BNT162b2 after two doses of CoronaVac in Thai health care workers

Authors: Amonrphat Kitro, Wachiranun Sirikul, Weeraya Thongkum, Suthinee Soponpong, Umpa Yasamut, Wuttipat Kiratipaisarl, Apiradee Kosai, Watchara Kasinrerk, Chatchai Tayapiwatana, Kriengkrai Srithanaviboonchai

Journal: Vaccine

PubMed ID: 35430106

Doi: 10.1016/j.vaccine.2022.04.020

Topology of the Enterobacterial Common Antigen polymerase WzyE

Authors: Nicholas T Maczuga, Elizabeth N H Tran, Renato Morona

Journal: Microbiology (Reading)

PubMed ID: 35470793

Doi: 10.1099/mic.0.001183

Products & Services: Polyclonal Antibody Services

Correction to "Febuxostat Prevents the Cytotoxicity of Propofol in Brain Endothelial Cells"

Authors: Jianli Hao, Weiqing Zhang, Rui Tong, Zeqing Huang

Journal: ACS Omega

PubMed ID: 35465124

Doi: 10.1021/acsomega.2c01716

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Recombinant Limosilactobacillus (Lactobacillus) delivering nanobodies against Clostridium perfringens NetB and alpha toxin confers potential protection from necrotic enteritis

Authors: Dharanesh Gangaiah, Valerie Ryan, Daphne Van Hoesel, Shrinivasrao P Mane, Enid T Mckinley, Nallakannu Lakshmanan, Nandakumar D Reddy, Edward Dolk, Arvind Kumar

Journal: Microbiologyopen

PubMed ID: 35478283

Doi: 10.1002/mbo3.1270

Products & Services: Protein and Antibody Isolation

NEAT1: Culprit lncRNA linking PIG-C, MSLN, and CD80 in triple-negative breast cancer

Authors: Nada H Hussein, Reda A Eissa, M de Bruyn, Hend M El Tayebi

Journal: Life Sci

PubMed ID: 35378140

Doi: 10.1016/j.lfs.2022.120523

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Dataset of high-throughput ligand screening against the RNA Packaging Signals regulating Hepatitis B Virus nucleocapsid formation

Authors: Fardokht Abulwerdi, Farzad Fatehi, Iain W Manfield, Stuart F J Le Grice, John S Schneekloth, Reidun Twarock, Peter G Stockley, Nikesh Patel

Journal: Data Brief

PubMed ID: 35516001

Doi: 10.1016/j.dib.2022.108206

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CCPG1 involved in corneal infection

Authors: Li-Mei Wang, Xiao-Meng Chen, Hai-Jing Yan, Shu Yan, Xiao-Yan Sun, Da-Wei Zhang, Hua Yang, Dan-Li Lu, Cheng-Ye Che

Journal: Int J Ophthalmol

PubMed ID: 35450172

Doi: 10.18240/ijo.2022.04.03

Products & Services: Protein and Antibody Isolation

Cloning and Organelle Expression of Bamboo Mitochondrial Complex I Subunits Nad1, Nad2, Nad4, and Nad5 in the Yeast

Authors: Hsieh-Chin Tsai, Cheng-Hung Hsieh, Ching-Wen Hsu, Yau-Heiu Hsu, Lee-Feng Chien

Journal: Int J Mol Sci

PubMed ID: 35409414

Doi: 10.3390/ijms23074054

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LPS Response Is Impaired by Urban Fine Particulate Matter

Authors: Natália de Souza Xavier Costa, Gabriel Ribeiro Júnior, Adair Aparecida Dos Santos Alemany, Luciano Belotti, Marcela Frota Cavalcante, Susan Ribeiro, Mariana Matera Veras, Esper Georges Kallás, Paulo Hilário Nascimento Saldiva, Marisa Dolhnikoff, Luiz Fernando Ferraz da Silva

Journal: Int J Mol Sci

PubMed ID: 35409273

Doi: 10.3390/ijms23073913

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Ethyl Gallate Dual-Targeting PTPN6 and PPARγ Shows Anti-Diabetic and Anti-Obese Effects

Authors: Dohee Ahn, Jinsoo Kim, Gibeom Nam, Xiaodi Zhao, Jihee Kwon, Ji Young Hwang, Jae Kwan Kim, Sun-Young Yoon, Sang J Chung

Journal: Int J Mol Sci

PubMed ID: 35563411

Doi: 10.3390/ijms23095020

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Identification and characterization of novel endolysins targeting Gardnerella vaginalis biofilms to treat bacterial vaginosis

Authors: Sara Arroyo-Moreno, Matthew Cummings, David B Corcoran, Aidan Coffey, Ronan R McCarthy

Journal: NPJ Biofilms Microbiomes

PubMed ID: 35440653

Doi: 10.1038/s41522-022-00285-0

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Peptide Permeation across a Phosphocholine Membrane: An Atomically Detailed Mechanism Determined through Simulations and Supported by Experimentation

Authors: Alfredo E Cardenas, Chad I Drexler, Rachel Nechushtai, Ron Mittler, Assaf Friedler, Lauren J Webb, Ron Elber

Journal: J Phys Chem B

PubMed ID: 35388695

Doi: 10.1021/acs.jpcb.1c10966

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MicroRNA-217 modulates pancreatic cancer progression via targeting ATAD2

Authors: Madhuri Dutta, Biswajit Das, Debasish Mohapatra, Padmanava Behera, Shantibhusan Senapati, Anasuya Roychowdhury

Journal: Life Sci

PubMed ID: 35504332

Doi: 10.1016/j.lfs.2022.120592

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Immunoreactivity of humanized single-chain variable fragment against its functional epitope on domain 1 of CD147

Authors: Nutjeera Intasai, Kuntalee Rangnoi, Montarop Yamabhai, Thanathat Pamonsupornwichit, Weeraya Thongkum, Umpa Yasamut, Koollawat Chupradit, Nuchjira Takheaw, Piyarat Nimmanpipug, Chatchai Tayapiwatana

Journal: Sci Rep

PubMed ID: 35468972

Doi: 10.1038/s41598-022-10657-3

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A genetic toolkit and gene switches to limit Mycoplasma growth for biosafety applications

Authors: Alicia Broto, Erika Gaspari, Samuel Miravet-Verde, Vitor A P Martins Dos Santos, Mark Isalan

Journal: Nat Commun

PubMed ID: 35393441

Doi: 10.1038/s41467-022-29574-0

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