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Towards a generic prototyping approach for therapeutically-relevant peptides and proteins in a cell-free translation system

Authors: Yue Wu, Zhenling Cui, Yen-Hua Huang, Simon J de Veer, Andrey V Aralov, Zhong Guo, Shayli V Moradi, Alexandra O Hinton, Jennifer R Deuis, Shaodong Guo, Kai-En Chen, Brett M Collins, Irina Vetter, Volker Herzig, Alun Jones, Matthew A Cooper, Glenn F King, David J Craik, Kirill Alexandrov, Sergey Mureev

Journal: Nat Commun

PubMed ID: 35017494

Doi: 10.1038/s41467-021-27854-9

Products & Services: DNA Sequencing

Dietary Isoflavones Alter Gut Microbiota and Lipopolysaccharide Biosynthesis to Reduce Inflammation

Authors: Sudeep Ghimire, Nicole M Cady, Peter Lehman, Stephanie R Peterson, Shailesh K Shahi, Faraz Rashid, Shailendra Giri, Ashutosh K Mangalam

Journal: Gut Microbes

PubMed ID: 36179318

Doi: 10.1080/19490976.2022.2127446

Products & Services: Endotoxin Detection & Removal System

Identification of sequence-specific promoters driving polycistronic transcription initiation by RNA polymerase II in trypanosomes

Authors: Carlos Cordon-Obras, Claudia Gomez-Liñan, Sara Torres-Rusillo, Isabel Vidal-Cobo, Diana Lopez-Farfan, Alicia Barroso-Del Jesus, Domingo Rojas-Barros, Mark Carrington, Miguel Navarro

Journal: Cell Rep

PubMed ID: 35021094

Doi: 10.1016/j.celrep.2021.110221

Products & Services: GenParts™ DNA Fragments

FACI Is a Novel CREB-H-Induced Protein That Inhibits Intestinal Lipid Absorption and Reverses Diet-Induced Obesity

Authors: Yun Cheng, Xiao-Zhuo Kang, Tao Cheng, Zi-Wei Ye, George L Tipoe, Cheng-Han Yu, Chi-Ming Wong, Baohua Liu, Chi-Ping Chan, Dong-Yan Jin

Journal: Cell Mol Gastroenterol Hepatol

PubMed ID: 35093589

Doi: 10.1016/j.jcmgh.2022.01.017

Products & Services: Stable Cell Lines

The Impact of Tyrosine Iodination on the Aggregation and Cleavage Kinetics of MMP-9-Responsive Peptide Sequences

Authors: Douglas S MacPherson, Scott A McPhee, Brian M Zeglis, Rein V Ulijn

Journal: ACS Biomater Sci Eng

PubMed ID: 35050574

Doi: 10.1021/acsbiomaterials.1c01488

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Novel Neutralizing Epitope of PEDV S1 Protein Identified by IgM Monoclonal Antibody

Authors: Techit Thavorasak, Monrat Chulanetra, Kittirat Glab-Ampai, Karsidete Teeranitayatarn, Thaweesak Songserm, Rungrueang Yodsheewan, Nawannaporn Sae-Lim, Porntippa Lekcharoensuk, Nitat Sookrung, Wanpen Chaicumpa

Journal: Viruses

PubMed ID: 35062329

Doi: 10.3390/v14010125

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Efficacy and immunogenicity of MultiTEP-based DNA vaccines targeting human α-synuclein: prelude for IND enabling studies

Authors: Changyoun Kim, Armine Hovakimyan, Karen Zagorski, Tatevik Antonyan, Irina Petrushina, Hayk Davtyan, Gor Chailyan, Jonathan Hasselmann, Michiyo Iba, Anthony Adame, Edward Rockenstein, Marcell Szabo, Mathew Blurton-Jones, David H Cribbs, Anahit Ghochikyan, Eliezer Masliah, Michael G Agadjanyan

Journal: npj Vaccines

PubMed ID: 35013319

Doi: 10.1038/s41541-021-00424-2

Products & Services: Gene Synthesis

Expression of Lineage Transcription Factors Identifies Differences in Transition States of Induced Human Oligodendrocyte Differentiation

Authors: Florian J Raabe, Marius Stephan, Jan Benedikt Waldeck, Verena Huber, Damianos Demetriou, Nirmal Kannaiyan, Sabrina Galinski, Laura V Glaser, Michael C Wehr, Michael J Ziller, Andrea Schmitt, Peter Falkai, Moritz J Rossner

Journal: Cells

PubMed ID: 35053357

Doi: 10.3390/cells11020241

Products & Services: Plasmid DNA Preparation

Altered succinylation of mitochondrial proteins, APP and tau in Alzheimer's disease

Authors: Yun Yang, Victor Tapias, Diana Acosta, Hui Xu, Huanlian Chen, Ruchika Bhawal, Elizabeth T Anderson, Elena Ivanova, Hening Lin, Botir T Sagdullaev, Jianer Chen, William L Klein, Kirsten L Viola, Sam Gandy, Vahram Haroutunian, M Flint Beal, David Eliezer, Sheng Zhang, Gary E Gibson

Journal: Nat Commun

PubMed ID: 35013160

Doi: 10.1038/s41467-021-27572-2

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Shoc2 recognizes bacterial flagellin and mediates antibacterial Erk/Stat signaling in an invertebrate

Authors: Bao-Rui Zhao, Xin-Xin Wang, Xian-Wei Wang

Journal: PLoS Pathog

PubMed ID: 35073369

Doi: 10.1371/journal.ppat.1010253

Products & Services: Proteins, Expression, Isolation and Analysis

The temporal gene expression profiles of calcium and phosphorus transporters in Hy-Line Brown layers

Authors: Xiaojuan Wang, Peng Li, Jingpeng Zhao, Hongchao Jiao, Hai Lin

Journal: Poult Sci

PubMed ID: 35202896

Doi: 10.1016/j.psj.2022.101736

Products & Services: Catalog Antibody

SARS-CoV-2 NSP13 Inhibits Type I IFN Production by Degradation of TBK1 via p62-Dependent Selective Autophagy

Authors: Chao Sui, Tongyang Xiao, Shengyuan Zhang, Hongxiang Zeng, Yi Zheng, Bingyu Liu, Gang Xu, Chengjiang Gao, Zheng Zhang

Journal: J Immunol

PubMed ID: 34996837

Doi: 10.4049/jimmunol.2100684

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Silencing of circCDC14A prevents cerebral ischemia-reperfusion injury via miR-23a-3p/CXCL12 axis

Authors: Huiyi Huo, Chao Hu, Yongxue Lu, Jinyu Zhou, Zhiguang Mai

Journal: J Biochem Mol Toxicol

PubMed ID: 34978116

Doi: 10.1002/jbt.22982

Products & Services: Gene Synthesis

Plant-Based Vaccines in Combat against Coronavirus Diseases

Authors: Benita Ortega-Berlanga, Tomasz Pniewski

Journal: Vaccines (Basel)

PubMed ID: 35214597

Doi: 10.3390/vaccines10020138

Products & Services: Proteins, Expression, Isolation and Analysis

NMR Detection and Structural Modeling of the Ethylene Receptor LeETR2 from Tomato

Authors: Shukun Wei, Yaqing Yang, Yuan Yuan, Lingyu Du, Hongjuan Xue, Bo OuYang

Journal: Membranes (Basel)

PubMed ID: 35207029

Doi: 10.3390/membranes12020107

Products & Services: Custom DNA/RNA Oligos

Genome-Wide Identification and Expression Profiles of Genes in L

Authors: Meng Lu, Xiang-Xiao Meng, Yi-Ming Zhang, Xue-Wen Zhu, Jun Li, Wei-Qiang Chen, Hui-Hua Wan, Si-Fan Wang, Xue Cao, Wei Sun, Yao-Lei Mi, Jun-Wen Zhai

Journal: Cannabis Cannabinoid Res

PubMed ID: 35020417

Doi: 10.1089/can.2021.0153

Products & Services: Protein Tools

Hemagglutinin-based DNA vaccines containing trimeric self-assembling nanoparticles confer protection against influenza

Authors: Yongbo Qiao, Shenghui Jin, Jiaojiao Nie, Yaotian Chang, Bo Wang, Shanshan Guan, Qinghan Li, Yuhua Shi, Wei Kong, Yaming Shan

Journal: J Leukoc Biol

PubMed ID: 35040188

Doi: 10.1002/JLB.6A1021-535R

Products & Services: Mammalian Expression

Role of Nse1 Subunit of SMC5/6 Complex as a Ubiquitin Ligase

Authors: Peter Kolesar, Karel Stejskal, David Potesil, Johanne M Murray, Jan J Palecek

Journal: Cells

PubMed ID: 35011726

Doi: 10.3390/cells11010165

Products & Services: Custom Vector Construction

Role of Nse1 Subunit of SMC5/6 Complex as a Ubiquitin Ligase

Authors: Peter Kolesar, Karel Stejskal, David Potesil, Johanne M Murray, Jan J Palecek

Journal: Cells

PubMed ID: 35011726

Doi: 10.3390/cells11010165

Products & Services: Custom Vector Construction

Characterization of a Broadly Neutralizing Monoclonal Antibody against SARS-CoV-2 Variants

Authors: Tasnim Saifudin Zakir, Tao Meng, Lee Ching Pei Carmen, Justin Jang Hann Chu, Raymond Tzer Pin Lin, Mookkan Prabakaran

Journal: Viruses

PubMed ID: 35215823

Doi: 10.3390/v14020230

Products & Services: Recombinant Proteins

theLiTE™: A Screening Platform to Identify Compounds that Reinforce Tight Junctions

Authors: Teresa Lopes Gomes, Virgínia de Oliveira-Marques, Richard John Hampson, António Jacinto, Luciana Vieira de Moraes, Rui Gonçalo Martinho

Journal: Front Pharmacol

PubMed ID: 35069190

Doi: 10.3389/fphar.2021.752787

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Suppression of Airway Allergic Reactions by a Photocatalytic Filter Using Mouse Model

Authors: Taisuke Tomonaga, Hiroto Izumi, Chinatsu Nishida, Kaori Kato, Kazuhiro Yatera, Etsushi Kuroda, Yasuo Morimoto

Journal: Toxics

PubMed ID: 35051082

Doi: 10.3390/toxics10010040

Products & Services: Endotoxin Detection & Removal System

Suppression of Airway Allergic Reactions by a Photocatalytic Filter Using Mouse Model

Authors: Taisuke Tomonaga, Hiroto Izumi, Chinatsu Nishida, Kaori Kato, Kazuhiro Yatera, Etsushi Kuroda, Yasuo Morimoto

Journal: Toxics

PubMed ID: 35051082

Doi: 10.3390/toxics10010040

Products & Services: Endotoxin Detection & Removal System

Porcine circovirus type 2 infection inhibits the activation of type I interferon signaling via capsid protein and host gC1qR

Authors: Zhenyu Wang, Jing Chen, Qiong-Ge Zhang, Kai Huang, Dan Ma, Qian Du, Dewen Tong, Yong Huang

Journal: Vet Microbiol

PubMed ID: 35085949

Doi: 10.1016/j.vetmic.2022.109354

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lnc-MRGPRF-6:1 Promotes M1 Polarization of Macrophage and Inflammatory Response through the TLR4-MyD88-MAPK Pathway

Authors: Dan Hu, Yuzhong Wang, Zhihuan You, Yingfei Lu, Caihong Liang

Journal: Mediators Inflamm

PubMed ID: 35125964

Doi: 10.1155/2022/6979117

Products & Services: Custom DNA/RNA Oligos

Targeted deletion of liver-expressed Choriogenin L results in the production of soft eggs and infertility in medaka, Oryzias latipes

Authors: Kenji Murata, Masato Kinoshita

Journal: Zoological Lett

PubMed ID: 34983666

Doi: 10.1186/s40851-021-00185-9

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Active immunization combined with cisplatin confers enhanced therapeutic protection and prevents relapses of HPV-induced tumors at different anatomical sites

Authors: Bruna Felício Milazzotto Maldonado Porchia, Luana Raposo de Melo Moraes Aps, Ana Carolina Ramos Moreno, Jamile Ramos da Silva, Mariângela de Oliveira Silva, Natiely Silva Sales, Rubens Prince Dos Santos Alves, Clarissa Ribeiro Reily Rocha, Matheus Molina Silva, Karine Bitencourt Rodrigues, Tácita Borges Barros, Roberta Liberato Pagni, Patrícia da Cruz Souza, Mariana de Oliveira Diniz, Luís Carlos de Souza Ferreira

Journal: Int J Biol Sci

PubMed ID: 34975315

Doi: 10.7150/ijbs.56644

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Elemicin exposure induced aberrant lipid metabolism via modulation of gut microbiota in mice

Authors: Yi Zhang, Mufan Ji, Zhenyang Gu, Wenlong Pei, Jun Zhu, Qian Wu, Lei Li, Zhan Zhang

Journal: Toxicology

PubMed ID: 34979169

Doi: 10.1016/j.tox.2021.153088

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Intranasal curcumin and dexamethasone combination ameliorates inflammasome (NLRP3) activation in lipopolysachharide exposed asthma exacerbations

Authors: Anju Jaiswal, D Dash, Rashmi Singh

Journal: Toxicol Appl Pharmacol

PubMed ID: 34998855

Doi: 10.1016/j.taap.2021.115861

Products & Services: Endotoxin Detection & Removal System

Directed Evolution of Replication-Competent Double-Stranded DNA Bacteriophage toward New Host Specificity

Authors: Jing Liang, Huibin Zhang, Yee Ling Tan, Huimin Zhao, Ee Lui Ang

Journal: ACS Synth Biol

PubMed ID: 35090114

Doi: 10.1021/acssynbio.1c00319

Products & Services: GenParts™ DNA Fragments

Ethylene response factor MdERF4 and histone deacetylase MdHDA19 suppress apple fruit ripening through histone deacetylation of ripening related genes

Authors: Yanan Hu, Zhenyun Han, Ting Wang, Hua Li, Qiqi Li, Shuai Wang, Ji Tian, Yi Wang, Xinzhong Zhang, Xuefeng Xu, Zhenhai Han, Peitao Lü, Ting Wu

Journal: Plant Physiol

PubMed ID: 35088866

Doi: 10.1093/plphys/kiac016

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Speed dating for enzymes! Finding the perfect phosphopantetheinyl transferase partner for your polyketide synthase

Authors: Tobias Bruun Pedersen, Mikkel Rank Nielsen, Sebastian Birkedal Kristensen, Eva Mie Lang Spedtsberg, Trine Sørensen, Celine Petersen, Jens Muff, Teis Esben Sondergaard, Kåre Lehmann Nielsen, Reinhard Wimmer, Donald Max Gardiner, Jens Laurids Sørensen

Journal: Microb Cell Fact

PubMed ID: 35012550

Doi: 10.1186/s12934-021-01734-9

Products & Services: Codon Optimization

A biomimetic enzyme-linked immunosorbent assay (BELISA) for the analysis of gonadorelin by using molecularly imprinted polymer-coated microplates

Authors: Francesca Torrini, Laura Caponi, Andrea Bertolini, Pasquale Palladino, Francesca Cipolli, Alessandro Saba, Aldo Paolicchi, Simona Scarano, Maria Minunni

Journal: Anal Bioanal Chem

PubMed ID: 35028691

Doi: 10.1007/s00216-021-03867-7

Products & Services: ORF cDNA Clones/MolecularCloud

Initiator-Directed Transcription: Fission Yeast Nmtl Initiator Directs Preinitiation Complex Formation and Transcriptional Initiation

Authors: Diego A Rojas, Fabiola Urbina, Lucía Valenzuela-Pérez, Lorenzo Leiva, Vicente J Miralles, Edio Maldonado

Journal: Genes (Basel)

PubMed ID: 35205301

Doi: 10.3390/genes13020256

Products & Services: Gene Synthesis

Authors: Xiaohui Yuan, Han Xue, Xiaomeng Xu, Xinan Jiao, Zhiming Pan, Yunzeng Zhang

Journal: Gut Pathog

PubMed ID: 35078518

Doi: 10.1186/s13099-022-00480-6

Products & Services: DNA Sequencing

Inhibitory effects of specific combination of natural compounds against SARS-CoV-2 and its Alpha, Beta, Gamma, Delta, Kappa, and Mu variants

Authors: Anna Goc, Aleksandra Niedzwiecki, Vadim Ivanov, Svetlana Ivanova, Matthias Rath

Journal: Eur J Microbiol Immunol (Bp)

PubMed ID: 35060921

Doi: 10.1556/1886.2021.00022

Products & Services: Proteins, Expression, Isolation and Analysis

High cell surface expression and peptide binding affinity of HLA-DQA1*05:03, a susceptible allele of neuromyelitis optica spectrum disorders (NMOSD)

Authors: Shohei Beppu, Makoto Kinoshita, Jan Wilamowski, Tadahiro Suenaga, Yoshiaki Yasumizu, Kotaro Ogawa, Teruyuki Ishikura, Satoru Tada, Toru Koda, Hisashi Murata, Naoyuki Shiraishi, Yasuko Sugiyama, Keigo Kihara, Tomoyuki Sugimoto, Hisashi Arase, Daron M Standley, Tatsusada Okuno, Hideki Mochizuki

Journal: Sci Rep

PubMed ID: 34997058

Doi: 10.1038/s41598-021-04074-1

Products & Services: Peptide Synthesis

Porcine TRIM21 Enhances Porcine Circovirus 2 Infection and Host Immune Responses, But Inhibits Apoptosis of PCV2-Infected Cells

Authors: Lin Yang, Xiaohua Liu, Liying Zhang, Xue Li, Xinwei Zhang, Guoyu Niu, Weilong Ji, Si Chen, Hongsheng Ouyang, Linzhu Ren

Journal: Viruses

PubMed ID: 35062360

Doi: 10.3390/v14010156

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Targeted gene silencing in the nervous system with CRISPR-Cas13

Authors: Jackson E Powell, Colin K W Lim, Ramya Krishnan, Tristan X McCallister, Christian Saporito-Magriña, Maria A Zeballos, Garrett D McPheron, Thomas Gaj

Journal: Sci Adv

PubMed ID: 35044815

Doi: 10.1126/sciadv.abk2485

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Two phylogenetically unrelated peptide-receptor modules jointly regulate lateral root initiation via a partially shared signaling pathway in Arabidopsis thaliana

Authors: Joris Jourquin, Ana Ibis Fernandez, Boris Parizot, Ke Xu, Wim Grunewald, Akihito Mamiya, Hidehiro Fukaki, Tom Beeckman

Journal: New Phytol

PubMed ID: 34913488

Doi: 10.1111/nph.17919

Products & Services: Proteins, Expression, Isolation and Analysis

The CinB Nuclease from No Is Sufficient for Induction of Cytoplasmic Incompatibility in

Authors: Guangxin Sun, Mengwen Zhang, Hongli Chen, Mark Hochstrasser

Journal: MBio

PubMed ID: 35073749

Doi: 10.1128/mbio.03177-21

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A De Novo Optimized Cell-Free System for the Expression of Soluble and Active Human Tumor Necrosis Factor-Alpha

Authors: Nawal Abd El-Baky, Esmail M El-Fakharany, Soraya A Sabry, Ehab R El-Helow, Elrashdy Mustafa Redwan, Amira Sabry

Journal: Biology (Basel)

PubMed ID: 35205024

Doi: 10.3390/biology11020157

Products & Services: Mammalian Expression

Orthogonal proteomics methods to unravel the HOTAIR interactome

Authors: Louis Delhaye, Edith De Bruycker, Pieter-Jan Volders, Daria Fijalkowska, Delphine De Sutter, Sven Degroeve, Lennart Martens, Pieter Mestdagh, Sven Eyckerman

Journal: Sci Rep

PubMed ID: 35087108

Doi: 10.1038/s41598-022-05405-6

Products & Services: Proteins, Expression, Isolation and Analysis

Mitochondrial Dysfunction Associates With Acute T Lymphocytopenia and Impaired Functionality in COVID-19 Patients

Authors: Yufei Mo, Kelvin Kai-Wang To, Runhong Zhou, Li Liu, Tianyu Cao, Haode Huang, Zhenglong Du, Chun Yu Hubert Lim, Lok-Yan Yim, Tsz-Yat Luk, Jacky Man-Chun Chan, Thomas Shiu-Hong Chik, Daphne Pui-Ling Lau, Owen Tak-Yin Tsang, Anthony Raymond Tam, Ivan Fan-Ngai Hung, Kwok-Yung Yuen, Zhiwei Chen

Journal: Front Immunol

PubMed ID: 35095881

Doi: 10.3389/fimmu.2021.799896

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Immunogenicity of Oxford-AstraZeneca COVID-19 Vaccine in Vietnamese Health-Care Workers

Authors: Nguyen Van Vinh Chau, Lam Anh Nguyet, Nguyen Thanh Truong, Le Mau Toan, Nguyen Thanh Dung, Le Manh Hung, Mai Thanh Nhan, Dinh Nguyen Huy Man, Nghiem My Ngoc, Huynh Phuong Thao, Tran Nguyen Hoang Tu, Huynh Kim Mai, Do Thai Hung, Nguyen Thi Han Ny, Le Kim Thanh, Nguyen To Anh, Nguyen Thi Thu Hong, Le Nguyen Truc Nhu, Lam Minh Yen, Marc Choisy, Tran Tan Thanh, Guy Thwaites, Le Van Tan

Journal: Am J Trop Med Hyg

PubMed ID: 34996048

Doi: 10.4269/ajtmh.21-0849

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Inhibition of microRNA-448 suppresses CD4 T cell inflammatory activation via up-regulating suppressor of cytokine signaling 5 in systemic lupus erythematosus

Authors: Jing Zhang, Yun Guo, Yue Sun, Lihua Chang, Xiaofei Wang

Journal: Biochem Biophys Res Commun

PubMed ID: 35121374

Doi: 10.1016/j.bbrc.2022.01.097

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NCAPH promotes cell proliferation and inhibits cell apoptosis of bladder cancer cells through MEK/ERK signaling pathway

Authors: Bo Li, Qian Xiao, Liping Shan, Yongsheng Song

Journal: Cell Cycle

PubMed ID: 34974790

Doi: 10.1080/15384101.2021.2021050

Products & Services: Plasmid DNA Preparation

Involvement of β-cyanoalanine synthase (β-CAS) and sulfurtransferase (ST) in cyanide (CN) assimilation in rice seedlings

Authors: Yu-Xi Feng, Cheng-Zhi Li, Yu-Juan Lin, Xiao-Zhang Yu

Journal: Chemosphere

PubMed ID: 35101430

Doi: 10.1016/j.chemosphere.2022.133789

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Preparation and characterization of 2-deacetyl-3-O-sulfo-heparosan and its antitumor effects via the fibroblast growth factor receptor pathway

Authors: Zhengqi Zha, Yaoyao Liu, Yinghua Miao, Shiying Liao, Su-Yan Wang, Huiling Tang, Hongping Yin

Journal: Int J Biol Macromol

PubMed ID: 34998873

Doi: 10.1016/j.ijbiomac.2021.12.098

Products & Services: Plasmid DNA Preparation

A phage parasite deploys a nicking nuclease effector to inhibit viral host replication

Authors: Kristen N LeGault, Zachary K Barth, Peter DePaola, Kimberley D Seed

Journal: Nucleic Acids Res

PubMed ID: 35066583

Doi: 10.1093/nar/gkac002

Products & Services: Gene Synthesis

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