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Acute diacylglycerol production activates critical membrane-shaping proteins leading to mitochondrial tubulation and fission

Authors: Joshua G Pemberton, Krishnendu Roy, Yeun Ju Kim, Tara D Fischer, Vijay Joshi, Elizabeth Ferrer, Richard J Youle, Thomas J Pucadyil, Tamas Balla

Journal: Nature Communications

PubMed ID: 40102394

Doi: 10.1038/s41467-025-57439-9

Products & Services: Custom Vector Construction

Reprogramming yeast metabolism for customized starch-rich micro-grain through low-carbon microbial manufacturing

Authors: Zhihui Shi, Zhaoyu Xu, Weihe Rong, Hongbing Sun, Hongyi Zhou, Qianqian Yuan, Aixuan Xiao, Hongfei Ma, Tao Cai, Guokun Wang, Yanhe Ma

Journal: Nature Communications

PubMed ID: 40118900

Doi: 10.1038/s41467-025-58067-z

Products & Services: Custom Vector Construction

Pathway-instructed therapeutic selection of ruxolitinib reduces neuroinflammation in fungal postinfectious inflammatory syndrome

Authors: Jessica C Hargarten, Kenneth Ssebambulidde, Seher H Anjum, Malcolm J Vaughan, Jintao Xu, Anutosh Ganguly, Brittany Dulek, Francisco Otaizo-Carrasquero, Brian Song, Sijia Tao, Yoon-Dong Park, Terri L Scott, Tracey-Ann Höltermann, Raymond F Schinazi, Prashant Chittiboina, Bridgette Jeanne Billioux, Dima A Hammoud, Michal A Olszewski, Peter R Williamson

Journal: SCIENCE ADVANCES

PubMed ID: 40117367

Doi: 10.1126/sciadv.adi9885

Products & Services: Protein Electrophoresis and Western

Integrative in silico and biochemical analyses demonstrate direct Arl3-mediated ODA16 release from the intraflagellar transport machinery

Authors: Jiaolong Wang, Rune T Kidmose, Niels Boegholm, Nevin K Zacharia, Mads B Thomsen, Anni Christensen, Tara Malik, Karl Lechtreck, Esben Lorentzen

Journal: The Journal of Biological Chemistry

PubMed ID: 39880089

Doi: 10.1016/j.jbc.2025.108237

Products & Services: Gene Synthesis Codon Optimization

Cell-autonomous innate immunity by proteasome-derived defence peptides

Authors: Karin Goldberg, Arseniy Lobov, Paola Antonello, Merav D Shmueli, Idan Yakir, Tal Weizman, Adi Ulman, Daoud Sheban, Einav Laser, Matthias P Kramer, Ronen Shteinvil, Guoyun Chen, Angham Ibraheem, Vera Sysoeva, Vered Fishbain-Yoskovitz, Gayatree Mohapatra, Anat Abramov, Sandy Shimshi, Kseniia Ogneva, Madhurima Nandy, Sivan Amidror, Hadar Bootz-Maoz, Shanny H Kuo, Nili Dezorella, Assaf Kacen, Aaron Javitt, Gee W Lau, Nissan Yissachar, Zvi Hayouka, Yifat Merbl

Journal: Nature

PubMed ID: 40044870

Doi: 10.1038/s41586-025-08615-w

Products & Services: Peptide Synthesis

Structure and dynamics of GAD65 in complex with an autoimmune polyendocrine syndrome type 2-associated autoantibody

Authors: Susanne H D Ständer, Cyril F Reboul, Sarah N Le, Daniel E Williams, Peter G Chandler, Mauricio G S Costa, David E Hoke, John D T Jimma, James Fodor, Gustavo Fenalti, Stuart I Mannering, Benjamin T Porebski, Peter Schofield, Daniel Christ, Malcolm Buckle, Sheena McGowan, Dominika Elmlund, Kasper D Rand, Ashley M Buckle

Journal: Nature Communications

PubMed ID: 40055307

Doi: 10.1038/s41467-025-57492-4

Products & Services: Gene Synthesis

Splenic red pulp macrophages eliminate the liver-resistant Streptococcus pneumoniae from the blood circulation of mice

Authors: Haoran An, Yijia Huang, Zhifeng Zhao, Kunpeng Li, Jingjing Meng, Xueting Huang, Xianbin Tian, Hongyu Zhou, Jiamin Wu, Qionghai Dai, Jing-Ren Zhang

Journal: SCIENCE ADVANCES

PubMed ID: 40073120

Doi: 10.1126/sciadv.adq6399

Products & Services: Protein and Antibody Isolation

PNPLA6 regulates retinal homeostasis by choline through phospholipid turnover

Authors: Takashi Ono, Yoshitaka Taketomi, Takayoshi Higashi, Hiroyasu Sato, Chika Mochizuki-Ono, Yuki Nagasaki, Takashi Ueta, Takashi Miyai, Suzumi M Tokuoka, Yoshiya Oda, Yasumasa Nishito, Tomio Ono, Choji Taya, Satoru Arata, Sumiko Watanabe, Tomoyoshi Soga, Tetsuya Hirabayashi, Makoto Aihara, Makoto Murakami

Journal: Nature Communications

PubMed ID: 40082403

Doi: 10.1038/s41467-025-57402-8

Products & Services: Custom Vector Construction

A CPC-shelterin-BTR axis regulates mitotic telomere deprotection

Authors: Diana Romero-Zamora, Samuel Rogers, Ronnie Ren Jie Low, Scott G Page, Blake J E Lane, Shunya Kosaka, Andrew B Robinson, Lucy French, Noa Lamm, Fuyuki Ishikawa, Makoto T Hayashi, Anthony J Cesare

Journal: Nature Communications

PubMed ID: 40097392

Doi: 10.1038/s41467-025-57456-8

Products & Services: Polyclonal Antibody Services

FGF2 Mediated USP42-PPARγ Axis Activation Ameliorates Liver Oxidative Damage and Promotes Regeneration

Authors: Nanfei Yang, Qiang Tian, Zhenli Lei, Shuxin Wang, Nan Cheng, Zhen Wang, Xianqin Jiang, Xuqun Zheng, Wenjing Xu, Minyan Ye, Longwei Zhao, Meiyun Wen, Jianlou Niu, Weijian Sun, Pingping Shen, Zhifeng Huang, Xiaokun Li

Journal: Advanced Science

PubMed ID: 40091484

Doi: 10.1002/advs.202408724

Products & Services: Recombinant Proteins