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The intrinsic substrate specificity of the human tyrosine kinome

Authors: Tomer M. Yaron-Barir, Brian A. Joughin, Emily M. Huntsman, Alexander Kerelsky, Daniel M. Cizin, Benjamin M. Cohen, Amit Regev, Junho Song, Neil Vasan, Ting-Yu Lin, Jose M. Orozco, Christina Schoenherr, Cari Sagum, Mark T. Bedford, R. Max Wynn, Shih-Chia Tso, David T. Chuang, Lei Li, Shawn S.-C. Li, Pau Creixell, Konstantin Krismer, Mina Takegami, Harin Lee, Bin Zhang, Jingyi Lu, Ian Cossentino, Sean D. Landry, Mohamed Uduman, John Blenis, Olivier Elemento, Margaret C. Frame, Peter V. Hornbeck, Lewis C. Cantley, Benjamin E. Turk, Michael B. Yaffe & Jared L. Johnson

Journal: Nature

PubMed ID: 38720073

Doi: 10.1038/s41586-024-07407-y

Products & Services: Codon Optimization

Mycobacterial biotin synthases require an auxiliary protein to convert dethiobiotin into biotin

Authors: Di Qu, Peng Ge, Laure Botella, Sae Woong Park, Ha-Na Lee, Natalie Thornton, James M. Bean, Inna V. Krieger, James C. Sacchettini, Sabine Ehrt, Courtney C. Aldrich & Dirk Schnappinger

Journal: Nat Commun

PubMed ID: 38755122

Doi: 10.1038/s41467-024-48448-1.

Products & Services: Catalog Antibodies

Contemporary HIV-1 consensus Env with AI-assisted redesigned hypervariable loops promote antibody binding

Authors: Hongjun Bai, Eric Lewitus, Yifan Li, Paul V. Thomas, Michelle Zemil, Mélanie Merbah, Caroline E. Peterson, Thujitha Thuraisamy, Phyllis A. Rees, Agnes Hajduczki, Vincent Dussupt, Bonnie Slike, Letzibeth Mendez-Rivera, Annika Schmid, Erin Kavusak, Mekhala Rao, Gabriel Smith, Jessica Frey, Alicea Sims, Lindsay Wieczorek, Victoria Polonis, Shelly J. Krebs, Julie A. Ake, Sandhya Vasan, Diane L. Bolton, M. Gordon Joyce, Samantha Townsley & Morgane Rolland

Journal: Nat Commun

PubMed ID: 38724518

Doi: 10.1038/s41467-024-48139-x

Products & Services: Gene Synthesis

Structural basis for double-stranded RNA recognition by SID1

Authors: Runhao Wang, Ye Cong, Dandan Qian, Chuangye Yan, Deshun Gong

Journal: Nucleic Acids Res

PubMed ID: 38742627

Doi: 10.1093/nar/gkae395

Enhanced detection of ligand-PPARγ binding based on surface plasmon resonance through complexation with SRC1- or NCOR2-related polypeptide

Authors: Yiting Wang , Mingzhu Luo , Luyang Che , Qixin Wu , Jingzhe Li , Yanyan Ma , Jingyi Wang , Changzhen Liu

Journal: International Journal of Biological Macromolecules

PubMed ID: 38670200

Doi: 10.1016/j.ijbiomac.2024.131865

Products & Services: Gene Synthesis

A Tag-Free Platform for Synthesis and Screening of Cyclic Peptide Libraries

Authors: Angele Bruce , Victor Adebomi , Patrick Czabala , Jonathan Palmer , William M McFadden , Zachary C Lorson , Ryan L Slack , Gaurav Bhardwaj , Stefan G Sarafianos , Monika Raj

Journal: Angew Chem Int Ed Engl

PubMed ID: 38529717

Doi: 10.1002/anie.202320045

Products & Services: PCR Cloning and Subcloning

Gene network-based and ensemble modeling-based selection of tumor-associated antigens with a predicted low risk of tissue damage for targeted immunotherapy

Authors: Christopher Lischer, Martin Eberhardt, Cindy Flamann, Johannes Berges, Esther Güse, Anja Wessely, Adrian Weich, Jimmy Retzlaff, Jan Dörrie, Niels Schaft, Manuel Wiesinger, Johannes März, Beatrice Schuler-Thurner, Harald Knorr, Shailendra Gupta, Krishna Pal Singh, Gerold Schuler, Markus Vincent Heppt, Elias Andreas Thomas Koch, Nadine D van Kleef, Julian J Freen-van Heeren, Annelies W Turksma, Olaf Wolkenhauer, Bettina Hohberger, Carola Berking, Heiko Bruns, Julio Vera

Journal: J Immunother Cancer

PubMed ID: 38724462

Doi: 10.1136/jitc-2023-008104

Products & Services: Gene Synthesis

CircZFR promotes colorectal cancer progression via stabilizing BCLAF1 and regulating the miR-3127-5p/RTKN2 axis

Authors: Jiaxin Chen, Huijuan Wang, Jianbin Xu, Engeng Chen, Qing Meng, Jiawei Wang, Haoyi Xiang, Wei Zhou, Ge Shan, Zhenyu Ju, Zhangfa Song

Journal: Sci China Life Sci

PubMed ID: 38805063

Doi: 10.1007/s11427-023-2514-y

Products & Services: Protein and Antibody Isolation

Structure-Based Virtual Screening for Methyltransferase Inhibitors of SARS-CoV-2 nsp14 and nsp16

Authors: Kejue Wu, Yinfeng Guo, Tiefeng Xu, Weifeng Huang, Deyin Guo, Liu Cao, Jinping Lei

Journal: Molecules

PubMed ID: 38792173

Doi: 10.3390/molecules29102312

Products & Services: Molecular Biology Reagents

Design, synthesis and evaluation of thieno[3,2-d]pyrimidine derivatives as novel potent CDK7 inhibitors

Authors: Hongjin Zhang, Guohao Lin, Suyun Jia, Jianbo Wu, Ying Zhang, Yanxin Tao, Weixue Huang, Meiru Song, Ke Ding, Dawei Ma, Mengyang Fan

Journal: Bioorg Chem

PubMed ID: 38761706

Doi: 10.1016/j.bioorg.2024.107456

Products & Services: Recombinant Proteins