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Discovery of a Dual IDO1/TDO Inhibitor That Modulates Enzymatic Activity and IDO1/SHP‑2 Signaling

Authors: Sarah Jane Rezzi, Andrea Butticè, Salvatore Villani, Gaia Lesca, Sofia Rossini, Eleonora Panfili, Daniele Mazzoletti, Elia Bari, Davide Violante, Marta Serafini, Alberto Massarotti, Ciriana Orabona, Maria Teresa Pallotta, Silvio Aprile, Silvia Fallarini, Erika Del Grosso, Rita Maria Concetta Di Martino, Riccardo Miggiano, Tracey Pirali

Journal: Journal of Medicinal Chemistr

PubMed ID: 42483959

Doi: 10.1021/acs.jmedchem.6c00759

Products & Services: Gene Synthesis

An Ancestral Mechanism of Calmodulin Binding to Cds1 Kinase Inhibits Catalytic Activity

Authors: Stephanie A Manovella, Tingting Wang, Samuel N Young, Toby A Dite, Vineet Vaibhav, Steve Binos, Laura F Dagley, Anh T N Nguyen, Anthony R Means, Janni Petersen, John W Scott, James M Murphy, Christopher R Horne

Journal: IUBMB Life

PubMed ID: 42655879

Doi: 10.1002/iub.70128.

Products & Services: Peptide Synthesis

Repolarization-gated potentiation and imaging of macrophages with engineered oncolytic bacteria for on-demand immunotherapy

Authors: Jing Jia, Guangming Li, Lei Li, Ying An, Chaoyi Yang, Yuru Wang, Huangxian Ju

Journal: Science China Chemistry

Doi: doi.org/10.1007/s11426-026-3771-5

Products & Services: Plasmid DNA Preparation

An Epstein-Barr Virus Nuclear Antigen 1 (EBNA1) Serology Test Strip for Nasopharyngeal Carcinoma Risk Screening

Authors: Benjamin E Warner, Japan Patel, Rebecca Satterwhite, Renwei Wang, Jennifer Adams-Haduch, Woon-Puay Koh, Jian-Min Yuan, Kathy H Y Shair

Journal: Journal of medical virology

PubMed ID: 42504130

Doi: 10.1002/jmv.71082

Products & Services: Protein and Antibody Isolation

A recyclable antibody shield preserves LDL receptor homeostasis and enables durable lipid control without immune complex formation

Authors: Yifeng Han, Peng Qian, Yuxin Li, Xiaozhen Kang, Peng Zou, Bohao He, Jiwu Wei

Journal: Pharmacological research

PubMed ID: 42562083

Doi: 10.1016/j.phrs.2026.108371

Products & Services: Protein Electrophoresis and Western

BCL9 inhibition promotes fibroblast lipogenesis by regulating macrophage–fibroblast interactions to attenuate pulmonary fibrosis

Authors: Wenjie Wang, Yuan Zhang, Fenglian He, Li Sun, Huiyu Li, Rongchen Liu, Guanglin Zhong, Ling Zhang, Anqi Li, Mei Feng, Yuxuan Dong, Xiaoxuan Lu, Xiaojin Wang, Yuan Si, Yejun Wu, Mengmeng Zhao, Dafu Zhu, Zhuyi Xi, Jian Chen, Jing Chen, Ming-Wei Wang, Di Zhu, Likun Gong, Bingshun Wang

Journal: Signal transduction and targeted therapy

PubMed ID: 42543261

Doi: doi.org/10.1038/s41392-026-02753-x

Products & Services: Recombinant Proteins

Performance of a modular robotic cluster matches skilled human operators for complex cell therapy manufacturing tasks

Authors: Sudeshna Sadhu, Brigitte Schmittlein, Angela Lares, Sunaina Nayak, Marco Uboldi, Yifan Yu, Jiawei Wang, Wei Zhang, Prajakta P. Bhanap, Yongchang Ji, Andrew Scheffler, John Wilson, Dan Welch, Nikolaos Gkitsas-Long, Aidan Jeffery Retherford, Ramya Tunuguntla, Alice Melocchi, Federico Parietti, Steven A. Feldman, Jonathan H. Esensten

Journal: International journal of pharmaceutics:X

PubMed ID: 42621923

Doi: 10.1016/j.ijpx.2026.100631.

Products & Services: Cell Isolation

Photocatalytic Golgi Proteomics Reveals Palmitoylation-Regulated Golgiphagy

Authors: Yufei Di, Fuhu Guo, Ziqi Liu, Haotian Guo, Linghao Kong, Peng R Chen, Xinyuan Fan

Journal: Journal of the American Chemical Society

PubMed ID: 42619132

Doi: 10.1021/jacs.6c13532

Products & Services: Gene Synthesis

PepGate: A Dual-Path Diffusion Framework for ACE Inhibitory Peptide De Novo Design

Authors: Wanhao Sun, Xihe Yang, Xin Huang, Neng Xiong, Hongru Feng, Yuanjiang Pan

Journal: Journal of Medicinal Chemistry

Doi: 10.1021/acs.jmedchem.6c01875

Products & Services: Peptide Synthesis

Nitro Reduction-Based RNA Control and Ultrafast Release

Authors: Yiran Zhao, Senfeng Zhang, Junsong Guo, Tuan-Khoa Kha, Song Chen, Chunyi Hu, Ru-Yi Zhu

Journal: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

PubMed ID: 42554310

Doi: 10.1002/anie.9746658

Products & Services: Synthetic Guide RNA