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A Modified Variant of Fasciola hepatica FhSAP-2 (mFhSAP-2) as a Recombinant Vaccine Candidate Induces High-Avidity IgG2c Antibodies and Enhances T Cell Activation in C57BL/6 Mice

Authors: Riseilly Ramos-Nieves; Albersy Armina-Rodriguez; Maria Del Mar Figueroa-Gispert; Ghalib Figueroa-Qui ones; Carlimar Ocasio-Malav ; Ana M. Espino

Journal: Vaccines

PubMed ID: 40432154

Doi: 10.3390/vaccines13050545

De novo design of a two-step approach targeting Claudin-6 for enhanced drug delivery to solid tumors

Authors: Jiayao Yan; Liqing Zhong; Xiaotong Chen; Lin Li; Fangcen Liu; Lei Lei; Mengchao An; Xiao Wei; Ying Wang; Tianran Chen; Jingyi Guo; Jie Shao; Xiaoxiao Yu; Yingjie Zhao; Rutian Li; Qin Liu; Baorui Liu

Journal: Journal of translational medicine

PubMed ID: 41267074

Doi: 10.1186/s12967-025-07316-2

De novo design of a two-step approach targeting Claudin-6 for enhanced drug delivery to solid tumors

Journal: Journal of translational medicine

PubMed ID: 41267074

Doi: 10.1186/s12967-025-07316-2

Structural mechanisms underlying the modulation of CXCR4 by diverse small-molecule antagonists

Authors: Xiaohong Sang, Haizhan Jiao, Qian Meng, Xiong Fang, Qi Pan, Jiao Zhou, Tingli Qian, Wanqin Zhang, Yan Xu, Jing An, Ziwei Huang, Hongli Hu

Journal: Proceedings of the National Academy of Sciences of the United States of America

PubMed ID: 40063796

Doi: 10.1073/pnas.2425795122

Products & Services: Gene Synthesis

Large Library Docking for Polypharmacology

Authors: Yujin Wu; Seth Vigneron; Joao Braz; Karthik Srinivasan; Elissa A. Fink; Xi-Ping Huang; Xinyu Xu; Harald Huebner; Joseph Y. Kim; Jing Wang; Tara Pfeiffer; Kensuke Sakamoto; Dmytro S. Radchenko; Ramona M. Rodriguiz; Yurii S. Moroz; John J. Irwin; Peter Gmeiner; Christian Billesboelle; Bryan L. Roth; Allan I. Basbaum; Aashish Manglik; William C. Wetsel; Brian K. Shoichet

Journal: Journal of Medicinal Chemistry

PubMed ID: 41712624

Doi: 10.1021/acs.jmedchem.5c03810

Products & Services: Peptide Synthesis

Large Library Docking for Polypharmacology

Journal: Journal of Medicinal Chemistry

PubMed ID: 41712624

Doi: 10.1021/acs.jmedchem.5c03810

Products & Services: Peptide Synthesis

Large Library Docking for Polypharmacology

Journal: Journal of Medicinal Chemistry

PubMed ID: 41712624

Doi: 10.1021/acs.jmedchem.5c03810

Products & Services: Peptide Synthesis

A Modified Variant of Fasciola hepatica FhSAP-2 (mFhSAP-2) as a Recombinant Vaccine Candidate Induces High-Avidity IgG2c Antibodies and Enhances T Cell Activation in C57BL/6 Mice

Authors: Riseilly Ramos-Nieves; Albersy Armina-Rodriguez; Maria Del Mar Figueroa-Gispert; Ghalib Figueroa-Qui ones; Carlimar Ocasio-Malav ; Ana M. Espino

Journal: Vaccines

PubMed ID: 40432154

Doi: 10.3390/vaccines13050545

Structural basis for the allosteric activation of Lon by the heat shock protein LarA

Authors: Hsiu-Jung Wang, Yun-Erh Kuan, Meng-Ru Ho, Chung-I Chang

Journal: Nature Communications

PubMed ID: 40044692

Doi: 10.1038/s41467-025-57482-6

Products & Services: Custom Vector Construction

Integration of multi-omics data accelerates molecular analysis of common wheat traits

Authors: Ning Zhang, Li Tang, Songgang Li, Lu Liu, Mengjuan Gao, Sisheng Wang, Daiying Chen, Yichao Zhao, Ruiqing Zheng, Armin Soleymaniniya, Lingran Zhang, Wenkang Wang, Xia Yang, Yan Ren, Congwei Sun, Mathias Wilhelm, Daowen Wang, Min Li, Feng Chen

Journal: Nature Communications

PubMed ID: 40038279

Doi: 10.1038/s41467-025-57550-x

Products & Services: Molecular Biology Tools