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An oral non-covalent non-peptidic inhibitor of SARS-CoV-2 Mpro ameliorates viral replication and pathogenesis in vivo

Authors: Nian E. Zhou; Su Tang; Xuelin Bian; Maloy K. Parai; Inna V. Krieger; Armando Flores; Pradeep K. Jaiswal; Radha Bam; Jeremy L. Wood; Zhe Shi; Laura J. Stevens; Trevor Scobey; Meghan V. Diefenbacher; Fernando R. Moreira; Thomas J. Baric; Arjun Acharya; Joonyoung Shin; Manish M. Rathi; Karen C. Wolff; Laura Riva; Malina A. Bakowski; Case W. McNamara; Nicholas J. Catanzaro; Rachel L. Graham; David C. Schultz; Sara Cherry; Yoshihiro Kawaoka; Peter J. Halfmann; Ralph S. Baric; Mark R. Denison; Timothy P. Sheahan; James C. Sacchettini

Journal: Cell Reports

PubMed ID: 39504242

Doi: 10.1016/j.celrep.2024.114929

Microvascular remodeling strategy for skin rejuvenation through microenvironmental reprogramming and appendage restoration

Authors: Jialiang Zhou, Shengjie Jiang, Liyun Wang, Tingting Dong, Li Yu, Haiyan Li, Zhen Gao, Jianyong Wu, Kaili Lin

Journal: Biomaterials

PubMed ID: 42107134

Doi: 10.1016/j.biomaterials.2026.124249

Products & Services: Protein Electrophoresis and Western

Quadruple pegRNA enables programmable and efficient large genomic insertion

Authors: Ya-Jing Shi, Zi-Yi Ding, Ying Wu, Zhou He, Yi-Zhou Zhang, Yu-Lu Zhang, Yu-Ming Zhang, Xiang-Rui Huang, Hao Yin, Ying Zhang

Journal: Nature

PubMed ID: 42020736

Doi: 10.1038/s41586-026-10395-w

Products & Services: Cell Isolation

Modulation of the pharmacokinetics of soluble ACE2 decoy receptors through glycosylation

Authors: Savanna Skeeters; Kamal Bagale; Galina Stepanyuk; David Thieker; Aaron Aguhob; Kui K. Chan; Benjamin Dutzar; Sergei Shalygin; Asif Shajahan; Xu Yang; Paul A. DaRosa; Emily Frazier; Maximilian M. Sauer; Lisa Bogatzki; Kelly A. Byrnes-Blake; Yifan Song; Parastoo Azadi; Eric Tarcha; Lianghui Zhang; Erik Procko

Journal: Molecular therapy. Methods & clinical development

PubMed ID: 39185275

Doi: 10.1016/j.omtm.2024.101301

Products & Services: Protein and Antibody Reagents

Structural and mechanistic profiling of Nurr1 modulation by vidofludimus enables structure-guided ligand design

Authors: rsula L pez-Garc a; Jan Vietor; Julian A. Marschner; Jan Heering; Vasily Morozov; Thomas Wein; Daniel Merk

Journal: Communications Chemistry

PubMed ID: 40399628

Doi: 10.1038/s42004-025-01553-8

Products & Services: Plasmid DNA Preparation

An oral non-covalent non-peptidic inhibitor of SARS-CoV-2 Mpro ameliorates viral replication and pathogenesis in vivo

Journal: Cell Reports

PubMed ID: 39504242

Doi: 10.1016/j.celrep.2024.114929

Multi-level Integrated Engineering Enhances Neutral β-Glucanase Production in Komagataella phaffii

Authors: Hai Xu, Xiaowei Shao, Yuzhe Peng, Xiuxia Liu, Chunli Liu, Zhonghu Bai, Yankun Yang

Journal: Journal of biotechnology

PubMed ID: 41999774

Doi: 10.1016/j.jbiotec

Modulation of the pharmacokinetics of soluble ACE2 decoy receptors through glycosylation

Journal: Molecular therapy. Methods & clinical development

PubMed ID: 39185275

Doi: 10.1016/j.omtm.2024.101301

Products & Services: Protein and Antibody Reagents

Regulation of cell dynamics by rapid integrin transport through the biosynthetic pathway

Authors: Martina Lerche; Mathilde Mathieu; Hellyeh Hamidi; Megan Chastney; Guillaume Jacquemet; Bart Marlon Herwig Bruininks; Shreyas Kaptan; Lene Maler d; Nina Marie Pedersen; Andreas Brech; Nobuyuki Matoba; Yuichiro Sato; Ilpo Vattulainen; Pere Roca-Cusachs; Franck Perez; Gaelle Boncompain; St phanie Miserey; Johanna Ivaska

Journal: The Journal of cell biology

PubMed ID: 41329164

Doi: 10.1083/jcb.202508155

Products & Services: Peptide Synthesis

Artemisinin exerts antidepressant-like effects via activation of AKT and ERK signaling pathways

Authors: Ruohong Lin; Zhiwei Zhou; Yizhou Jiang; Song Liu; Jinfeng Xie; Haitao Wang; Henning Ulrich; Wenhua Zheng

Journal: Frontiers in pharmacology

PubMed ID: 41181594

Doi: 10.3389/fphar.2025.1642167

Products & Services: Protein Electrophoresis and Western