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Non-AUG HIV-1 uORF translation elicits specific T cell immune response and regulates viral transcript expression

Authors: Emmanuel Labaronne, Didier Décimo, Lisa Bertrand, Laura Guiguettaz, Thibault J M Sohier, David Cluet, Valérie Vivet-Boudou, Ana Luiza Chaves Valadão, Clara Dahoui, Pauline François, Isabelle Hatin, Olivier Lambotte, Assia Samri, Brigitte Autran, Lucie Etienne, Caroline Goujon, Jean-Christophe Paillart, Olivier Namy, Bertha Cecilia Ramirez, Théophile Ohlmann, Arnaud Moris, Emiliano P Ricci

Journal: Nature Communications

PubMed ID: 39966383

Doi: 10.1038/s41467-025-56772-3

Products & Services: Peptide Synthesis

LCK-co-receptor association ensures T cell lineage fidelity and maximizes epitope-specific TCR diversity

Authors: Justin B Zhang, Priyanka Chaurasia, Angela Nguyen, Zijian Huang, Trang T Nguyen, Hui Xu, Mai T Tran, Hugh H Reid, Claerwen M Jones, Stefan A Schattgen, Daniel Thiele, Paul G Thomas, Jeanette Rientjes, Kim L Good-Jacobson, Roland Ruscher, Dene R Littler, Jamie Rossjohn, Pirooz Zareie, Nicole L La Gruta

Journal: Science immunology

PubMed ID: 39982976

Doi: 10.1126/sciimmunol.adp5016

Products & Services: Custom Vector Construction

A rational multi-target combination strategy for synergistic improvement of non-ribosomal peptide production

Authors: Hao Yan, Zhenguo Xin, Ziwei Sang, Xingwang Li, Jia Xie, Jiale Wu, Shen Pang, Ying Wen, Weishan Wang

Journal: Nature Communications

PubMed ID: 39987186

Doi: 10.1038/s41467-025-57073-5

Products & Services: Gene Synthesis

Pluripotency factor Tex10 finetunes Wnt signaling for spermatogenesis and primordial germ cell development

Authors: Feifei Yuan, Jihong Yang, Fanglin Ma, Zhe Hu, Vikas Malik, Ruge Zang, Dan Li, Xianle Shi, Xin Huang, Hongwei Zhou, Jianlong Wang

Journal: Nature Communications

PubMed ID: 39988597

Doi: 10.1038/s41467-025-57165-2

Products & Services: Protein Electrophoresis and Western

Structural Plasticity of RRE Stem-Loop II Modulates Nuclear Export of HIV-1 RNA

Authors: Manju Ojha; Lucia Hudson; Amanda Photenhauer; Trinity Zang; Lauren Lerew; len Ekesan; Jason Daniels; Megan Nguyen; Hardik Paudyal; Darrin M. York; Melanie D. Ohi; Jan Marchant; Paul D. Bieniasz; Deepak Koirala

Journal: biorxiv

PubMed ID: 40060702

Doi: 10.1101/2025.02.20.639096

Design and Binding Affinity of Antisense Peptides for Snake Venom Neutralization

Authors: Ivan Biru ; Tino eba; Marin Mari ; Mario Gabri evi ; Tin Weitner

Journal: Molecules

PubMed ID: 40005213

Doi: 10.3390/molecules30040903

Products & Services: Peptide Synthesis

Molecular mechanisms of drug resistance and compensation in SARS-CoV-2 main protease: the interplay between E166 and L50

Authors: Sarah N. Zvornicanin; Ala M. Shaqra; Julia Flynn; Heidi Carias Martinez; Weiping Jia; Stephanie Moquin; Dustin Dovala; Daniel N. Bolon; Nese Kurt Yilmaz; Celia A. Schiffer

Journal: MBio

PubMed ID: 40183562

Doi: 10.1128/mbio.04068-24

Products & Services: Peptide Synthesis

The serine protease DPP9 and the redox sensor KEAP1 form a mutually inhibitory complex

Authors: Lydia P. Tsamouri; Jeffrey C. Hsiao; Daniel A. Bachovchin

Journal: The Journal of Biological Chemistry

PubMed ID: 39615677

Doi: 10.1016/j.jbc.2024.108034

A single residue switch mediates the broad neutralization of Rotaviruses

Authors: Yang Huang, Feibo Song, Yuanjun Zeng, Hui Sun, Roufang Sheng, Xuechun Wang, Liqin Liu, Guoxing Luo, Yanan Jiang, Yaling Chen, Mengxuan Zhang, Shiyin Zhang, Ying Gu, Hai Yu, Shaowei Li, Tingdong Li, Qingbing Zheng, Shengxiang Ge, Jun Zhang & Ningshao Xia

Journal: Nature Communications

PubMed ID: 39833145

Doi: 10.1038/s41467-025-56114-3

Products & Services: Protein and Antibody Isolation

Blocking autophagosome closure manifests the roles of mammalian Atg8-family proteins in phagophore formation and expansion during nutrient starvation

Authors: Van Bui , Xinwen Liang , Yansheng Ye , William Giang , Fang Tian , Yoshinori Takahashi , Hong-Gang Wang

Journal: Autophagy

PubMed ID: 39694607

Doi: 10.1080/15548627.2024.2443300