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Phosphorylation-inducing chimera rewires oncogenic kinase to trigger apoptosis

Authors: Manuel L. Merz; Veronika M. Shoba; Rajaiah Pergu; Zachary C. Severance; Dhanushka N. P. Munkanatta Godage; Arghya Deb; Hui Si Kwok; Prashant Singh; Sameek Singh; Jonathan B. Allen; Wenzhi Tian; Pallavi M. Gosavi; Santosh K. Chaudhary; Viktoriya Anokhina; Ellen L. Weisberg; N. Connor Payne; Yao He; Reilly Osadchey; Mrinal Shekhar; Ralph Mazitschek; Matthew G. Rees; Jennifer A. Roth; Qiang Cui; James D. Griffin; Brian B. Liau; Amit Choudhary

Journal: biorxiv

PubMed ID: 40661463

Doi: 10.1101/2025.06.13.659082

Products & Services: PCR Cloning and Subcloning

Accurate de novo design of high-affinity protein-binding macrocycles using deep learning

Authors: Stephen A. Rettie; David Juergens; Victor Adebomi; Yensi Flores Bueso; Qinqin Zhao; Alexandria N. Leveille; Andi Liu; Asim K. Bera; Joana A. Wilms; Alina ffing; Alex Kang; Evans Brackenbrough; Mila Lamb; Stacey R. Gerben; Analisa Murray; Paul M. Levine; Maika Schneider; Vibha Vasireddy; Sergey Ovchinnikov; Oliver H. Weiergr ber; Dieter Willbold; Joshua A. Kritzer; Joseph D. Mougous; David Baker; Frank DiMaio; Gaurav Bhardwaj

Journal: Nature Chemical Biology

PubMed ID: 40542165

Doi: 10.1038/s41589-025-01929-w

Self-assembled epitope-based nanoparticles targeting the SARS-CoV-2 spike protein enhanced the immune response and induced potential broad neutralizing activity

Authors: Yue Liu; Chenxi Li; Zirui Wu; Yu Zhao; Tieyan Yin; Xiaopan Liu; Jiaru Hui; Qingyu Wang; Yi Pan; Yaming Shan; Xinglong Qu

Journal: Frontiers in cellular and infection microbiology

PubMed ID: 40270771

Doi: 10.3389/fcimb.2025.1560330

Machine learning-assisted substrate binding pocket engineering based on structural information

Authors: Xinglong Wang; Kangjie Xu; Xuan Zeng; Kai Linghu; Beichen Zhao; Shangyang Yu; Kun Wang; Shuyao Yu; Xinyi Zhao; Weizhu Zeng; Kai Wang; Jingwen Zhou

Journal: BRIEFINGS IN BIOINFORMATICS

PubMed ID: 39101501

Doi: 10.1093/bib/bbae381

Synergistic effects of retinol and retinyl palmitate in alleviating UVB-induced DNA damage and promoting the homologous recombination repair in keratinocytes

Authors: Jiangming Zhong; Ling Liang; Nan Zhao; Jing Wang; Peng Shu

Journal: Frontiers in pharmacology

PubMed ID: 40343007

Doi: 10.3389/fphar.2025.1562244

Products & Services: Protein Electrophoresis and Western

H19 influenza A virus exhibits species-specific MHC-II receptor usage

Authors: Umut Karakus; Ignacio Mena; Jithesh Kottur; Sara S. El Zahed; Roc o Seoane; Soner Yildiz; Leanne Chen; Magdalena Plancarte; LeAnn Lindsay; Rebecca Halpin; Timothy B Stockwell; David E. Wentworth; Geert-Jan Boons; Florian Krammer; Silke Stertz; Walter Boyce; Robert P de Vries; Aneel K Aggarwal; Adolfo Garc a-Sastre

Journal: Cell Host & Microbe

PubMed ID: 38889725

Doi: 10.1016/j.chom.2024.05.018

H19 influenza A virus exhibits species-specific MHC-II receptor usage

Journal: Cell Host & Microbe

PubMed ID: 38889725

Doi: 10.1016/j.chom.2024.05.018

A MERS-CoV-like mink coronavirus uses ACE2 as an entry receptor

Authors: Ningning Wang, Weiwei Ji, Houqi Jiao, Michael Veit, Ju Sun, Yanjun Wang, Xing Ma, Yu Wang, Yutong Wang, Xin-Xin Li, Xiaoguang Zhang, Jie Chen, Jiayu Wei, Ying Xu, Dawei Guo, Xiaofeng Zhai, Andres Merits, Chang Li, Félix A Rey, Georgi M Dobrikov, George F Gao, Shuijun Zhang, Yuhai Bi, Shuo Su

Journal: Nature

PubMed ID: 40306315

Doi: 10.1038/s41586-025-09007-w

Products & Services: Monoclonal Antibody Services

A New Vaccine Candidate Expressing JUNV GP1–GP2 Against Argentine Hemorrhagic Fever Based on Baculovirus Surface Display

Authors: Carla Tomatis, Mara C A M Aguiar, Nancy Charo, Silvia Aquila, Pablo D Thomas, Paula N Arrías, Matías L Pidre, Víctor Romanowski, Laura Riera, Julia Brignone, Andrea Maiza, Eugenio Antonio Carrera Silva, María Florencia Ferrer, Ricardo Martín Gómez

Journal: Current Microbiology

PubMed ID: 40514553

Doi: 10.1007/s00284-025-04320-z

Products & Services: Gene Synthesis

OsPRMT6b balances plant growth and high temperature stress by feedback inhibition of abscisic acid signaling

Authors: Xin Jin, Qibing Lin, Xinyue Zhang, Shuang Zhang, Weiwei Ma, Peike Sheng, Limin Zhang, Minxi Wu, Xudong Zhu, Zhiwei Li, Bojuan Liu, Jiachang Wang, Yupeng Wang, Kun Dong, Ming Yu, Yulong Ren, Zhijun Cheng, Cailin Lei, Xiuping Guo, Xin Wang, Haiyang Wang, Fu-Qing Wu, Shanshan Zhu, Jianmin Wan

Journal: Nature Communications

PubMed ID: 40467572

Doi: 10.1038/s41467-025-60350-y

Products & Services: Peptide Synthesis