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Deep Receptor Scanning Reveals General Sequence Constraints on GPCR Biosynthesis

Authors: Austin Tedman; Muskan Goel; Sohan Shah; Mathew K. Howard; Laura M. Chamness; Antonio Bonifasi; Ismalia Adams; Jacklyn M. Gallagher; Wesley D. Penn; Katarina Nemec; Eli F. McDonald; Brianna N. Corman; J. Paul Robinson; Carol Beth Post; Patricia L. Clark; M. Madan Babu; Aashish Manglik; Charles P. Kuntz; Willow Coyote-Maestas; Jonathan P. Schlebach

Journal: biorxiv

PubMed ID: 41000614

Doi: 10.1101/2025.09.19.677468

Synergistic chemo-immunotherapy for osteosarcoma via a pH-responsive multi-component nanoparticle system

Authors: Dapeng Li; Yuanfan Li; Jie Cang; Xianwen Yan; Feipeng Wu; Xuan Sun; Wenchao Zhang

Journal: Frontiers in pharmacology

PubMed ID: 40264674

Doi: 10.3389/fphar.2025.1584245

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Resistance to oxyimino-cephalosporins conferred by an alternative mechanism of hydrolysis by the Acinetobacter -derived cephalosporinase-33 (ADC-33), a class C -lactamase present in carbapenem-resistant Acinetobacter baumannii (CR Ab )

Authors: Rachel A. Powers; Bradley J. Wallar; Hannah R. Jarvis; Zoe X. Ziegler; Cynthia M. June; Christopher R. Bethel; Andrea M. Hujer; Magdalena A. Taracila; Susan D. Rudin; Kristine M. Hujer; Fabio Prati; Emilia Caselli; Robert A. Bonomo

Journal: MBio

PubMed ID: 40377322

Doi: 10.1128/mbio.00287-25

Phosphorylation-activated G protein signaling stabilizes TCP14 and JAZ3 to repress JA signaling and enhance plant immunity

Authors: Haiyan Jia, Natalie Hewitt, Lucía Jordá, Tigran M Abramyan, Josh Tolliver, Janice L Jones, Kinya Nomura, Jing Yang, Sheng-Yang He, Alexander Tropsha, Antonio Molina, Henrik G Dohlman, Alan M Jones

Journal: Molecular Plant

PubMed ID: 40509595

Doi: 10.1016/j.molp.2025.06.004

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Engineering precision zebrafish alleles of human disease

Authors: Holly R. Thomas; Bradley K. Yoder; Matthew S. Alexander; John M. Parant

Journal: biorxiv

PubMed ID: 40475461

Doi: 10.1101/2025.05.18.654701

Products & Services: Molecular Biology Reagents

Journal: MBio

PubMed ID: 40377322

Doi: 10.1128/mbio.00287-25

The herpes simplex origin-binding protein: mechanisms for sequence-specific DNA binding and dimerization revealed by Cryo-EM

Authors: Emil Gustavsson; Kay Gr newald; Per Elias; B Martin H llberg

Journal: Nucleic Acids Research

PubMed ID: 41125242

Doi: 10.1093/nar/gkaf1029

The herpes simplex origin-binding protein: mechanisms for sequence-specific DNA binding and dimerization revealed by Cryo-EM

Authors: Emil Gustavsson; Kay Gr newald; Per Elias; B Martin H llberg

Journal: Nucleic Acids Research

PubMed ID: 41125242

Doi: 10.1093/nar/gkaf1029

Metabotropic glutamate receptor 4-mediated glutamatfergic signaling reshapes the tumor microenvironment by regulating dendritic cell maturation

Authors: Xiaoman Ju, Eva Maria Putz, Yaqi Liu, Dongchen Yuan, Guowei Sun, Stephane Koda, Zhuo Fu, Simin Shao, Chunrong Tong, Biping Deng, Jing Hu, Juming Yan

Journal: Nature Communications

PubMed ID: 40593670

Doi: 10.1038/s41467-025-60922-y.

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CRISPRi screen identifies FprB as a synergistic target for gallium therapy in Pseudomonas aeruginosa

Authors: Yu Zhang, Tingting Zhang, Xue Xiao, Yejun Wang, Adam Kawalek, Jinzhao Ou, Anmin Ren, Wenhao Sun, Vincent de Bakker, Yujie Liu, Yuelong Li, Liang Yang, Liang Ye, Ning Jia, Jan-Willem Veening, Xue Liu

Journal: Nature Communications

PubMed ID: 40595632

Doi: 10.1038/s41467-025-61208-z

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