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Discovery of benzethonium chloride as a potent STAT3 inhibitor for the treatment of HNSCC

Authors: Yuefeng Han; Shumin Li; Deshang Chen; Mingjie Zhang; Guoying Han; QianQian Xu; Xianming Ge; Mengli Wang; Yan Pan; Sien Ma; Beibei Xu; Mengmeng Deng; Bao Zhao

Journal: Frontiers in pharmacology

PubMed ID: 40242440

Doi: 10.3389/fphar.2025.1569570

Products & Services: Protein and Antibody Isolation

Design, synthesis, and mechanism study of dimerized phenylalanine derivatives as novel HIV-1 capsid inhibitors

Authors: Xujie Zhang; Lin Sun; Megan E. Meuser; Waleed A. Zalloum; Shujing Xu; Tianguang Huang; Srinivasulu Cherukupalli; Xiangyi Jiang; Xiao Ding; Yucen Tao; Dongwei Kang; Erik De Clercq; Christophe Pannecouque; Alexej Dick; Simon Cocklin; Xinyong Liu; Peng Zhan

Journal: European Journal of Medicinal Chemistry

PubMed ID: 34592608

Doi: 10.1016/j.ejmech.2021.113848

Products & Services: Peptide Synthesis

Development of a single-dose Q fever vaccine with an injectable nanoparticle-loaded hydrogel: effect of sustained co-delivery of antigen and adjuvant

Authors: Lu Wang; Aaron Ramirez; Jiin Felgner; Enya Li; Jenny E. Hernandez-Davies; Anthony E. Gregory; Philip L. Felgner; Ali Mohraz; D. Huw Davies; Szu-Wen Wang

Journal: Drug Delivery

PubMed ID: 40314164

Doi: 10.1080/10717544.2025.2476144

Products & Services: Endotoxin Detection & Removal System

CAMPER: mechanistic artificial intelligence for designing peptides that target MRSA persisters

Authors: Fadi Shehadeh; Biswajit Mishra; Raquel Ferrer-Espada; Anindya Basu; LewisOscar Felix; Charilaos Dellis; Narchonai Ganesan; Liyang Zhang; Andrew T. Martens; Youlian Goulev; Michael B. Sherman; Johan Paulsson; Mandar T. Naik; Paul P. Sotiriadis; Eleftherios Mylonakis

Journal: Nature Communications

PubMed ID: 41803147

Doi: 10.1038/s41467-026-70348-9

Products & Services: Peptide Synthesis

CAMPER: mechanistic artificial intelligence for designing peptides that target MRSA persisters

Journal: Nature Communications

PubMed ID: 41803147

Doi: 10.1038/s41467-026-70348-9

Products & Services: Peptide Synthesis

Crystal structure of Alzheimer's disease phospholipase D3 provides a molecular basis for understanding its normal and pathological functions

Authors: Kenta Ishii; Stefan J. Hermans; Maria Eleni Georgopoulou; Tracy L. Nero; Nancy C. Hancock; Gabriela A. N. Crespi; Michael A. Gorman; Jonathan H. Gooi; Michael W. Parker

Journal: The FEBS journal

PubMed ID: 39325669

Doi: 10.1111/febs.17277

De Novo Multi Mechanism Antimicrobial Peptide Design via Multimodal Deep Learning

Authors: Xiaojuan Li; Haifan Gong; Yue Wang; Yinuo Zhao; Lixiang Li; Peijing Bao; Qingzhou Kong; Jialu Fu; Boyao Wan; Yumeng Zhang; Jinghui Zhang; Jiekun Ni; Zhongxue Han; Xueping Nan; Kunping Ju; Longfei Sun; Yuerui Ma; Huijun Chang; Mengqi Zheng; Yanbo Yu; Xiaoyun Yang; Xiuli Zuo; Haina Wang; Yanqing Li

Journal: Advanced Science

PubMed ID: 41801219

Doi: 10.1002/advs.202515835

Products & Services: Peptide Synthesis

Influence of expression and purification protocols on G biochemical activity: kinetics of plant and mammalian G protein cycles

Authors: Timothy E. Gookin; David Chakravorty; Sarah M. Assmann

Journal: Frontiers in molecular biosciences

PubMed ID: 40260404

Doi: 10.3389/fmolb.2025.1513660

Products & Services: Gene Synthesis

SIRT2-mediated deacetylation of LCK governs the magnitude of T cell receptor signaling

Authors: Imene Hamaidi; Pingyan Cheng; Soo Young Jun; Alak Manna; Min-Hsuan Wang; Anh Nguyen; Ismail Can; Min G. Zhang; Odesha O. Taylor; Luis Uriel Lopez Bailon; Bin Fang; Bradford Perez; Ben C. Creelan; Andriy Marusyk; Dongjun Shin; Tae Hyun Hwang; Anders E. Berglund; Virginia S. Shapiro; Haitao M. Ji; Jos R. Conejo-Garcia; Sungjune Kim

Journal: nature immunology

PubMed ID: 41611868

Doi: 10.1038/s41590-025-02377-3

Products & Services: Custom Vector Construction

SIRT2-mediated deacetylation of LCK governs the magnitude of T cell receptor signaling

Journal: nature immunology

PubMed ID: 41611868

Doi: 10.1038/s41590-025-02377-3

Products & Services: Custom Vector Construction