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Engineered depalmitoylases enable selective manipulation of protein localization and function

Authors: Srinidhi Jayaraman, Audrey Kochiss, Thy-Lan Alcalay, Pedro J. del Rivero Morfin & Manu Ben-Johny

Journal: Nature Communications

PubMed ID: 40223127

Doi: 10.1038/s41467-025-58908-x

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Chromosome end protection by RAP1-mediated inhibition of DNA-PK

Authors: Patrik Eickhoff, Ceylan Sonmez, Charlotte E. L. Fisher, Oviya Inian, Theodoros I. Roumeliotis, Angela dello Stritto, Jörg Mansfeld, Jyoti S. Choudhary, Sebastian Guettler, Francisca Lottersberger & Max E. Douglas

Journal: Nature

PubMed ID: 40240611

Doi: 10.1038/s41586-025-08896-1

Products & Services: Gene Synthesis

Hydrogels with programmed spatiotemporal mechanical cues for stem cell-assisted bone regeneration

Authors: Bin Xue, Zhengyu Xu, Lan Li, Kaiqiang Guo, Jing Mi, Haipeng Wu, Yiran Li, Chunmei Xie, Jing Jin, Juan Xu, Chunping Jiang, Xiaosong Gu, Meng Qin, Qing Jiang, Yi Cao & Wei Wang

Journal: Nature Communications

PubMed ID: 40240370

Doi: 10.1038/s41467-025-59016-6

Mechanism of small heat shock protein client sequestration and induced polydispersity

Authors: Adam P. Miller & Steve L. Reichow

Journal: Nature Communications

PubMed ID: 40240363

Doi: 10.1038/s41467-025-58964-3

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SNAP25-dependent membrane trafficking of the Kv1.5 channel regulates the onset of atrial fibrillation

Authors: Xuling Su, Beihua Shao, Zhiwen Chen, Hongcheng Gu, Ke Xiong, Guanghua Wang, Qicheng Zou, Yuting Cao, Caihong Zhang, Hongtao Xu, Yixin Yuan, Xuxia Zhao, Yi Liu, Yunli Shen, Duanyang Xie, Yi-Han Chen

Journal: Nature Communications

PubMed ID: 40253375

Doi: 10.1038/s41467-025-59096-4

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Mis-splicing-derived neoantigens and cognate TCRs in splicing factor mutant leukemias

Authors: Won Jun Kim, Edie I Crosse, Emma De Neef, Inaki Etxeberria, Erich Y Sabio, Eric Wang, Jan Philipp Bewersdorf, Kuan-Ting Lin, Sydney X Lu, Andrea Belleville, Nina Fox, Cynthia Castro, Pu Zhang, Takeshi Fujino, Jennifer Lewis, Jahan Rahman, Beatrice Zhang, Jacob H Winick, Alexander M Lewis, Robert F Stanley, Susan DeWolf, Brigita Meškauskaitė Urben, Meril Takizawa, Tobias Krause, Henrik Molina, Ronan Chaligne, Priya Koppikar, Jeffrey Molldrem, Mathieu Gigoux, Taha Merghoub, Anthony Daniyan, Smita S Chandran, Benjamin D Greenbaum, Christopher A Klebanoff, Robert K Bradley, Omar Abdel-Wahab

Journal: Cell

PubMed ID: 40273911

Doi: 10.1016/j.cell.2025.03.047

Products & Services: Gene Synthesis

Teleost GSDMEc regulates GSDMEa-mediated pyroptos

Authors: Hang Xu, Meng Wu, Yujian Wang, Yaoming Jiao, Yuan Chen, Zihao Yuan, Li Sun

Journal: J Adv Res

PubMed ID: 40210150

Doi: doi.org/10.1016/j.jare.2025.04.007

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The ribosome-associated quality control factor TCF25 imposes K48 specificity on Listerin-mediated ubiquitination of nascent chains by binding and specifically orienting the acceptor ubiquitin

Authors: Irina S Abaeva, Alexander G Bulakhov, Christopher U T Hellen, Tatyana V Pestova

Journal: Genes Dev

PubMed ID: 40169231

Doi: 10.1101/gad.352389.124

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BARD1-mediated stabilization of METTL14 promotes retinal neovascularization by m6A-modifying MXD1 mRNA on a YTHDF2-dependent manner

Authors: Xianyang Liu, Shuhao Zeng, Jiayu Meng, Qian Zhou, Fan Cao, Baorui Chu, Chao Wu, Yakun Wang, Hui Feng, Xiaorui Bi, Xinyuan Chen, Wenxian Yang, Meng Tian, Hui Yang, Ke Hu, Shengping Hou

Journal: Theranostics

Doi: 10.7150/thno.110122

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Development of a highly sensitive C1QC-targeting aptamer and its application in a modified antibody-aptamer sandwich biosensor for C1QC biomarker detection

Authors: Wenwei Wu, Lixia Qian, Jie Shen, Hongmei Li, Liang-cheng Li

Journal: Sensors and Actuators: B. Chemical

Doi: doi.org/10.1016/j.snb.2025.137828

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