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Human endogenous retrovirus K (HERV-K) envelope structures in pre- and postfusion by cryo-EM

Authors: Jeremy Shek; Chen Sun; Elise M. Wilson; Fatemeh Moadab; Kathryn M. Hastie; Roshan R. Rajamanickam; Patrick J. Penalosa; Stephanie S. Harkins; Diptiben Parekh; Chitra Hariharan; Dawid S. Zyla; Cassandra Yu; Kelly C. L. Shaffer; Victoria I. Lewis; Ruben Diaz Avalos; Tomas Mustelin; Erica Ollmann Saphire

Journal: SCIENCE ADVANCES

PubMed ID: 40864726

Doi: 10.1126/sciadv.ady8168

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Senotoxins target senescence via lipid binding specificity, ion imbalance and lipidome remodeling

Authors: Javier Moral-Sanz; Isabel Fern ndez-Carrasco; Valentina Ramponi; Amanda Garrido; Izhar Karbat; Pablo Cabezas-Sainz; Esperanza Rivera-de-Torre; Osama Elsallabi; Roberto Mart n-Hern ndez; Jos L. L pez-Aceituno; Nathan L. Price; Laura Sanchez; Gonzalo Colmenarejo; lvaro Mart nez-del-Pozo; Irina Vetter; Angel Cogolludo; Francisco Perez-Vizcaino; Jorge Del-Pozo; Eitan Reuveny; Manuel A. Fern ndez-Rojo; Paul D. Robbins; Rafael de Cabo; Manuel Serrano; Maria P. Ikonomopoulou

Journal: Nature Aging

PubMed ID: 41526742

Doi: 10.1038/s43587-025-01030-w

Products & Services: PCR Cloning and Subcloning

DUX4 is a multifunctional factor priming human embryonic genome activation

Authors: Sanna Vuoristo; Shruti Bhagat; Christel Hyd n-Granskog; Masahito Yoshihara; Lisa Gawriyski; Eeva-Mari Jouhilahti; Vipin Ranga; Mahlet Tamirat; Mikko Huhtala; Ida Kirjanov; Sonja Nyk nen; Kaarel Krjut kov; Anastassius Damdimopoulos; Jere Weltner; Kosuke Hashimoto; Ga lle Recher; Sini Ezer; Priit Paluoja; Pauliina Paloviita; Yujiro Takegami; Ai Kanemaru; Karolina Lundin; Tomi T. Airenne; Timo Otonkoski; Juha S. Tapanainen; Hideya Kawaji; Yasuhiro Murakawa; Thomas R. B rglin; Markku Varjosalo; Mark S. Johnson; Timo Tuuri; Shintaro Katayama; Juha Kere

Journal: iScience

PubMed ID: 35402882

Doi: 10.1016/j.isci.2022.104137

Products & Services: Peptide Synthesis

14-3-3 interaction with phosphodiesterase 8A sustains PKA signaling and downregulates the MAPK pathway

Authors: Soumita Mukherjee; Somesh Roy; Shruti Mukherjee; Amaravadhi Harikishore; Anirban Bhunia; Atin K. Mandal

Journal: The Journal of Biological Chemistry

PubMed ID: 38325743

Doi: 10.1016/j.jbc.2024.105725

14-3-3 interaction with phosphodiesterase 8A sustains PKA signaling and downregulates the MAPK pathway

Authors: Soumita Mukherjee; Somesh Roy; Shruti Mukherjee; Amaravadhi Harikishore; Anirban Bhunia; Atin K. Mandal

Journal: The Journal of Biological Chemistry

PubMed ID: 38325743

Doi: 10.1016/j.jbc.2024.105725

Characterization of Adenylyl Cyclase Isoform 6 Residues Interacting with Forskolin

Authors: Vikram Bhatia; Saeid Maghsoudi; Martha Hinton; Anjali Y. Bhagirath; Nisha Singh; Appalaraju Jaggupilli; Prashen Chelikani; Shyamala Dakshinamurti

Journal: Biology

PubMed ID: 37106773

Doi: 10.3390/biology12040572

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Functional Analysis of the Yeast Counterpart to the Human GCN2 p.Glu738_Asp739insArgArg Variant

Authors: Anja H Schiemann, Makhdoom Sarwar, Evelyn Sattlegger

Journal: microPublication biology

PubMed ID: 40880988

Doi: 10.17912/micropub.biology.001767

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Structural basis for small molecule binding to the SARS-CoV-2 nsp10-nsp14 ExoN complex

Authors: Frank Kozielski, Suzanne Zoë Fisher, Shumeng Ma, Fatma Al Busaidi, Ewa Krupinska, Maria Nyblom, Céleste Sele, Heather McDuffie Sullivan, Tobias Krojer, Wolfgang Knecht

Journal: Nucleic Acids Research

PubMed ID: 40794865

Doi: 10.1093/nar/gkaf753

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Anti-CV2/CRMP5 autoantibodies as drivers of sensory neuron excitability and pain in rats

Authors: Laurent Martin, Harrison J Stratton, Lyuba Y Salih, Nicolas LA Dumaire, Kimberly Gomez, Le Duy Do, Santiago Loya-Lopez, Cheng Tang, Aida Calderon-Rivera, Dongzhi Ran, Venkatrao Nunna, Shreya S Bellampalli, Liberty François-Moutal, Shizhen Luo, Frank Porreca, Mohab Ibrahim, Véronique Rogemond, Jérôme Honnorat, Rajesh Khanna, Aubin Moutal

Journal: Nature Communications

PubMed ID: 40775229

Doi: 10.1038/s41467-025-62380-y.

Products & Services: Peptide Synthesis

Functional and epitope specific monoclonal antibody discovery directly from immune sera using cryo-EM

Authors: James A Ferguson, Sai Sundar Rajan Raghavan, Garazi Peña Alzua, Disha Bhavsar, Jiachen Huang, Alesandra J Rodriguez, Jonathan L Torres, Maria Bottermann, Julianna Han, Florian Krammer, Facundo D Batista, Andrew B Ward

Journal: SCIENCE ADVANCES

PubMed ID: 40815640

Doi: 10.1126/sciadv.adv8257

Products & Services: Recombinant Antibody Expression