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Discovery of SARS-CoV-2 Papain-like Protease Inhibitors through a Combination of High-Throughput Screening and a FlipGFP-Based Reporter Assay

Authors: Chunlong Ma; Michael Dominic Sacco; Zilei Xia; George Lambrinidis; Julia Alma Townsend; Yanmei Hu; Xiangzhi Meng; Tommy Szeto; Mandy Ba; Xiujun Zhang; Maura Gongora; Fushun Zhang; Michael Thomas Marty; Yan Xiang; Antonios Kolocouris; Yu Chen; Jun Wang

Journal: ACS central science

PubMed ID: 34341772

Doi: 10.1021/acscentsci.1c00519

Virus glycoprotein nanodisc platform for vaccine design

Authors: Kimmo Rantalainen; Alessia Liguori; Gabriel Ozorowski; Claudia Flynn; Jon M. Steichen; Olivia Swanson; Patrick J. Madden; Sabyasachi Baboo; Swastik Phulera; Anant Gharpure; Danny Lu; Oleksandr Kalyuzhniy; Patrick Skog; Sierra Terada; Monolina Shil; Jolene K. Diedrich; Erik Georgeson; Ryan Tingle; Saman Eskandarzadeh; Wen-Hsin Lee; Nushin Alavi; Diana Goodwin; Michael Kubitz; Sonya Amirzehni; Sunny Himansu; Devin Sok; Jeong Hyun Lee; John R. Yates; James C. Paulson; Shane Crotty; Torben Schiffner; Andrew B. Ward; William R. Schief

Journal: biorxiv

PubMed ID: 40666859

Doi: 10.1101/2025.05.02.651272

Products & Services: Catalog Antibodies

Virus glycoprotein nanodisc platform for vaccine design

Journal: biorxiv

PubMed ID: 40666859

Doi: 10.1101/2025.05.02.651272

Products & Services: Catalog Antibodies

Targeting the Fusion Process of SARS-CoV-2 Infection by Small Molecule Inhibitors

Authors: Seung Bum Park; Parker Irvin; Zongyi Hu; Mohsin Khan; Xin Hu; Qiru Zeng; Catherine Chen; Miao Xu; Madeleine Leek; Ruochen Zang; James Brett Case; Wei Zheng; Siyuan Ding; T. Jake Liang

Journal: MBio

PubMed ID: 35012356

Doi: 10.1128/mbio.03238-21

Generation of Site-Specifically Labeled Affinity Reagents via Use of a Self-Labeling Single Domain Antibody

Authors: Stanley Fayn, Swarnali Roy, Chino C Cabalteja, Woonghee Lee, Hima Makala, Kwamena Baidoo, Divya Nambiar, Julia Sheehan-Klenk, Joon-Yong Chung, Jesse Buffington, Mitchell Ho, Freddy E Escorcia, Ross W Cheloha

Journal: Advanced Science

PubMed ID: 39965119

Doi: 10.1002/advs.202417160

Products & Services: Mammalian Expression

A rapid CAT transformation protocol and nuclear transgene expression tools for metabolic engineering in Cyanidioschyzon merolae 10D

Authors: Melany Villegas-Valencia, Martha R Stark, Mark Seger, Gordon B Wellman, Sebastian Overmans, Peter J Lammers, Stephen D Rader, Kyle J Lauersen

Journal: New biotechnology

Doi: 10.1016/j.nbt.2024.12.001

Products & Services: Gene Synthesis PCR Cloning and Subcloning

AMPlify: attentive deep learning model for discovery of novel antimicrobial peptides effective against WHO priority pathogens

Authors: Chenkai Li; Darcy Sutherland; S. Austin Hammond; Chen Yang; Figali Taho; Lauren Bergman; Simon Houston; Ren L. Warren; Titus Wong; Linda M. N. Hoang; Caroline E. Cameron; Caren C. Helbing; Inanc Birol

Journal: BMC Genomics

PubMed ID: 35078402

Doi: 10.1186/s12864-022-08310-4

Products & Services: Peptide Synthesis

AMPlify: attentive deep learning model for discovery of novel antimicrobial peptides effective against WHO priority pathogens

Journal: BMC Genomics

PubMed ID: 35078402

Doi: 10.1186/s12864-022-08310-4

Products & Services: Peptide Synthesis

AMPlify: attentive deep learning model for discovery of novel antimicrobial peptides effective against WHO priority pathogens

Journal: BMC Genomics

PubMed ID: 35078402

Doi: 10.1186/s12864-022-08310-4

Products & Services: Peptide Synthesis

Screening the human druggable genome identifies ABHD17B as an anti-fibrotic target in hepatic stellate cells

Authors: Wenyang Li, Robert P Sparks, Cheng Sun, Yang Yang, Lorena Pantano, Rory Kirchner, Nahid Arghiani, Arden Weilheimer, Benjamin J Toles, Jennifer Y Chen, Sean P Moran, Victor Barrera, Zixiu Li, Peng Zhou, Meghan L Brassil, David Wrobel, Shannan J Ho Sui, Gary Aspnes, Michael Schuler, Jennifer Smith, Benjamin D Medoff, Chan Zhou, Carine M Boustany-Kari, Jörg F Rippmann, Daniela M Santos, Julia F Doerner, Alan C Mullen

Journal: Nature Communications

PubMed ID: 40025044

Doi: 10.1038/s41467-025-56900-z

Products & Services: Gene Synthesis