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Discovery of SARS-CoV-2 Papain-like Protease Inhibitors through a Combination of High-Throughput Screening and a FlipGFP-Based Reporter Assay

Authors: Chunlong Ma; Michael Dominic Sacco; Zilei Xia; George Lambrinidis; Julia Alma Townsend; Yanmei Hu; Xiangzhi Meng; Tommy Szeto; Mandy Ba; Xiujun Zhang; Maura Gongora; Fushun Zhang; Michael Thomas Marty; Yan Xiang; Antonios Kolocouris; Yu Chen; Jun Wang

Journal: ACS central science

PubMed ID: 34341772

Doi: 10.1021/acscentsci.1c00519

Virus glycoprotein nanodisc platform for vaccine design

Authors: Kimmo Rantalainen; Alessia Liguori; Gabriel Ozorowski; Claudia Flynn; Jon M. Steichen; Olivia Swanson; Patrick J. Madden; Sabyasachi Baboo; Swastik Phulera; Anant Gharpure; Danny Lu; Oleksandr Kalyuzhniy; Patrick Skog; Sierra Terada; Monolina Shil; Jolene K. Diedrich; Erik Georgeson; Ryan Tingle; Saman Eskandarzadeh; Wen-Hsin Lee; Nushin Alavi; Diana Goodwin; Michael Kubitz; Sonya Amirzehni; Sunny Himansu; Devin Sok; Jeong Hyun Lee; John R. Yates; James C. Paulson; Shane Crotty; Torben Schiffner; Andrew B. Ward; William R. Schief

Journal: biorxiv

PubMed ID: 40666859

Doi: 10.1101/2025.05.02.651272

Products & Services: Catalog Antibodies

Virus glycoprotein nanodisc platform for vaccine design

Journal: biorxiv

PubMed ID: 40666859

Doi: 10.1101/2025.05.02.651272

Products & Services: Catalog Antibodies

Targeting the Fusion Process of SARS-CoV-2 Infection by Small Molecule Inhibitors

Authors: Seung Bum Park; Parker Irvin; Zongyi Hu; Mohsin Khan; Xin Hu; Qiru Zeng; Catherine Chen; Miao Xu; Madeleine Leek; Ruochen Zang; James Brett Case; Wei Zheng; Siyuan Ding; T. Jake Liang

Journal: MBio

PubMed ID: 35012356

Doi: 10.1128/mbio.03238-21

A chemical radar allows bacteria to detect and kill predators

Authors: Shuaibing Zhang, Kevin Schlabach, Victor Hugo Pérez Carrillo, Anan Ibrahim, Shahran Nayem, Anna Komor, Ruchira Mukherji, Somak Chowdhury, Lisa Reimer, Felix Trottmann, A Corina Vlot, Christian Hertweck, Ute A Hellmich, Pierre Stallforth

Journal: Cell

PubMed ID: 40179883

Doi: 10.1016/j.cell.2025.02.033

Effective extracellular payload release and immunomodulatory interactions govern the therapeutic effect of trastuzumab deruxtecan (T-DXd)

Authors: Li-Chung Tsao, John S. Wang, Xingru Ma, Sirajbir Sodhi, Joey V. Ragusa, Bushangqing Liu, Jason McBane, Tao Wang, Junping Wei, Cong-Xiao Liu, Xiao Yang, Gangjun Lei, Ivan Spasojevic, Ping Fan, Timothy N. Trotter, Michael Morse, Herbert Kim Lyerly & Zachary C. Hartman

Journal: Nature Communications

PubMed ID: 40175391

Doi: 10.1038/s41467-025-58266-8

Products & Services: CRISPR Plasmids

Redox disruption using electroactive liposome coated gold nanoparticles for cancer therapy

Authors: Ying-Chi Chen, Li-Chan Chang, Yan-Ling Liu, Ming-Che Chang, Yin-Fen Liu, Po-Ya Chang, Divinah Manoharan, Wen-Jyun Wang, Jia-Sin Chen, Hsueh-Chun Wang, Wen-Tai Chiu, Wei-Peng Li, Hwo-Shuenn Sheu, Wen-Pin Su & Chen-Sheng Yeh

Journal: Nature Communications

PubMed ID: 40188189

Doi: 10.1038/s41467-025-58636-2

Products & Services: Protein Electrophoresis and Western

The differential effect of SARS-CoV-2 NSP1 on mRNA translation and stability reveals new insights linking ribosome recruitment, codon usage, and virus evolution

Authors: Juan José Berlanga, Tania Matamoros, Miguel Rodríguez Pulido, Margarita Sáiz, Mercedes Núñez Bayón, René Toribio, Iván Ventoso

Journal: Nucleic Acids Research

PubMed ID: 40193709

Doi: 10.1093/nar/gkaf261

Products & Services: PCR Cloning and Subcloning

Immunotherapy with conventional type-1 dendritic cells induces immune memory and limits tumor relapse

Authors: Ignacio Heras-Murillo, Diego Mañanes, Pablo Munné, Vanessa Núñez, Jessica Herrera, Mauro Catalá-Montoro, Maite Alvarez, Miguel A. del Pozo, Ignacio Melero, Stefanie K. Wculek & David Sancho

Journal: Nature Communications

PubMed ID: 40204706

Doi: 10.1038/s41467-025-58289-1

Products & Services: Peptide Synthesis

A Versatile High-Throughput Single-Cell Screening Platform for Profiling Antigen-Specific Long-Lived B Cells in Blood and Bone Marrow

Authors: Tian Zhao, Yuqing Lei, Chang Liu, Dong Zhang, Kaiyi Li, Sisi Shan, Chenyu Li, Zimeng Wei, Yuhan Yang, Ting Zhang, Kai Sun, Haoran Sun, Linqi Zhang, Peng Liu

Journal: Advanced Science

PubMed ID: 40202243

Doi: 10.1002/advs.202414945

Products & Services: Protein and Antibody Isolation