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Lysosomal TMEM165 controls cellular ion homeostasis and survival by mediating lysosomal Ca2+ import and H+ efflux

Authors: Ran Chen, Bin Liu, Dawid Jaślan, Lucija Kucej, Veronika Kudrina, Belinda Warnke, Yvonne E Klingl, Arnas Petrauskas, Sandra Prat Castro, Kenji Maeda, Christian Grimm, Marja Jäättelä

Journal: Nature Communications

PubMed ID: 40473625

Doi: 10.1038/s41467-025-60349-5

Products & Services: PCR Cloning and Subcloning

The TRIP12 E3 ligase induces SWI/SNF component BRG1-β-catenin interaction to promote Wnt signaling

Authors: Sara Kassel, Kai Yuan, Nawat Bunnag, Leif R Neitzel, Wenhui Lu, Anna Schwarzkopf, Benjamin Maines, Matthew A Loberg, George Xu, Amber Adams, Andrew D McCray, Alex Cho, Mary Rockouski, Gemma Orton, Lily Goldsmith, Md Mubtaseem Ahnaf Aronno, Zachary T Spencer, Omar M Khan, Fei Ye, Charles Williams, Andres M Lebensohn, Rajat Rohatgi, Xiaofeng Wang, Vivian L Weiss, Charles C Hong, Arminja N Kettenbach, David J Robbins, Yashi Ahmed, Ethan Lee

Journal: Nature Communications

PubMed ID: 40473626

Doi: 10.1038/s41467-025-60535-5

Products & Services: PCR Cloning and Subcloning

Dissection of the immune landscape in psoriatic arthritis defines immunoproteasome up-regulation in treatment resistance

Authors: Reut Tzemach, Chamutal Gur, Truong San Phan, Eyal David, Mor Zada, Merav D Shmueli, Kfir Mazuz, Fadi Sheban, Anna Kurilovich, Maya Ben Yehuda, Victoria Furer, Ari Polachek, Smadar Gertel, Nimrod Snir, Tali Eviatar, Sharon Nevo, Yifat Merbl, Daphna Paran, Shuang-Yin Wang, Ori Elkayam, Ido Amit

Journal: Science immunology

PubMed ID: 40478933

Doi: 10.1126/sciimmunol.adu0284

Products & Services: Protein Electrophoresis and Western

The SH protein of mumps virus is a druggable pentameric viroporin

Authors: Kira Devantier, Trine L Toft-Bertelsen, Andreas Prestel, Viktoria M S Kjær, Cagla Sahin, Marco Giulini, Stavroula Louka, Katja Spiess, Asmita Manandhar, Katrine Qvortrup, Trond Ulven, Bo H Bentzen, Alexandre Mjj Bonvin, Nanna MacAulay, Birthe B Kragelund, Mette M Rosenkilde

Journal: SCIENCE ADVANCES

PubMed ID: 40479045

Doi: 10.1126/sciadv.ads3071

Products & Services: Bacterial Expression

Antagonistic Ghd7-OsNAC42 Complexes Modulate Carbon and Nitrogen Metabolism to Achieves Superior Quality and High Yield in Rice

Authors: Guangming Lou, Pingli Chen, Pingbo Li, Haozhou Gao, Jiawang Xiong, Shanshan Wan, Yuanyuan Zheng, Yufu Wang, Mufid Alam, Yingnanjun Chen, Lei Wang, Jingjing Bai, Xuan Tan, Wenting Rao, Bian Wu, Hao Zhou, Yanhua Li, Guanjun Gao, Qinglu Zhang, Jinghua Xiao, Xianghua Li, Xuelei Lai, Qifa Zhang, Yuqing He

Journal: Advanced Science

PubMed ID: 40492375

Doi: 10.1002/advs.202504163

Products & Services: Catalog Antibodies

Structures of vertebrate R2 retrotransposon complexes during target-primed reverse transcription and after second-strand nicking

Authors: Akanksha Thawani, Anthony Rodríguez-Vargas, Briana Van Treeck, Nozhat T Hassan, David L Adelson, Eva Nogales, Kathleen Collins

Journal: SCIENCE ADVANCES

PubMed ID: 40540573

Doi: 10.1126/sciadv.adu5533

Remodeling the Physicochemical and Pharmacokinetic Properties of PROTAC via Lipid Nanodisks for Cancer Therapy

Authors: Meichen Pan, Chunrong Yang, Zhongliang Fu, Yuchen Yang, Ying Zhuo, Hongwei Hou, Jinghong Li

Journal: Advanced Science

Doi: 10.1002/advs.202501384

Novel telomere-targeting dual-pharmacophore dinucleotide prodrugs for anticancer therapy

Authors: Ilgen Mender , Romina Girotti , Sergei Gryaznov

Journal: Nucleic Acids Research

PubMed ID: 40568934

Doi: 10.1093/nar/gkaf591

Products & Services: Protein Electrophoresis and Western

Dual-Modular Hydrogel Microparticles with Precision-Modulation of Inflammatory Microenvironment Dictate Full-Thickness Cartilage Regeneration for Osteoarthritis Repair

Authors: Xinye Chen, Yuanman Yu, Zirui He, Lina Pan, Jing Wang, Changsheng Liu

Journal: Advanced Science

Doi: 10.1002/advs.202504965

Products & Services: Peptide Synthesis

And then, proteins were resolved in 4–12% Bis-Tris SurePAGE gel (Genscript) and transferred to 0.45 µm PVDF membrane (Millipore) for blotting.

Authors: Sitao Zhang, Zixuan Jiang, Rundong Huang, Wenting Huang, Siyuan Peng, Shaoxun Mo, Letao Zhu, Peiheng Li, Ziyi Zhang, Emily Pan, Xi Chen, Yunfei Long, Qi Liang, Jin Tang, Renjing Xu, Rui Qing

Journal: Advanced Science

Doi: 10.1002/advs.202502723

Products & Services: Codon Optimization